Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 270, Issue -, Pages 7-11Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2016.06.018
Keywords
Transverse relaxation time; MRI; Degree of ordering of fibers
Ask authors/readers for more resources
Transverse spin-spin relaxation of liquids entrapped in nanocavities with different orientational order is theoretically investigated. Based on the bivariate normal distribution of nanocavities directions, we have calculated the anisotropy of the transverse relaxation time for biological systems, such as collagenous tissues, articular cartilage, and tendon. In the framework of the considered model, the dipole-dipole interaction is determined by a single coupling constant. The calculation results for the transverse relaxation time explain the angular dependence observed in MRI experiments with biological objects. The good agreement with the experimental data is obtained by adjustment of only one parameter which characterizes the disorder in fiber orientations. The relaxation time is correlated with the degree of ordering in biological tissues. Thus, microstructure of the tissues can be revealed from the measurement of relaxation time anisotropy. The clinical significance of the correlation, especially in the detection of damage must be evaluated in a large prospective clinical trials. (C) 2016 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available