A fast field-cycling device for high-resolution NMR: Design and application to spin relaxation and hyperpolarization experiments

A device for performing fast magnetic field-cycling NMR experiments is described. A key feature of this setup is that it combines fast switching of the external magnetic field and high-resolution NMR detection. The field-cycling method is based on precise mechanical positioning of the NMR probe with the mounted sample in the inhomogeneous fringe field of the spectrometer magnet. The device enables field variation over several decades (from 100 mu T up to 7 T) within less than 0.3 s; progress in NMR probe design provides NMR linewidths of about 10(-3) ppm. The experimental method is very versatile and enables site-specific studies of spin relaxation (NMRD, LLSs) and spin hyperpolarization (DNP, CIDNP, and SABRE) at variable magnetic field and at variable temperature. Experimental examples of such studies are demonstrated; advantages of the experimental method are described and existing challenges in the field are outlined. (C) 2016 Elsevier Inc. All rights reserved.