Multicomponent one-pot synthesis, characterization and antimicrobial screening of 2 cyanoimino-6-aryl-4-(6-methoxynaphthalen-2-yl)-3, 4-dihydro-1H-pyrimidines

The composite of 2-Cyanoimino-6-aryl-4-(6-methoxynaphthalen-2-yl)-3,4-dihydro-1 H-pyrimidines using 6-methoxy-2-naphthaldehyde and cyanoguanidine in the medium of aqueous sodium hydroxide in ethanol was documented. The structural designations for the aforementioned compounds were made using their spectra, which comprised Mass, FT-IR, H-1 and C-13 NMR. In vitro-antimicrobial testing of synthetic cyanoimino pyrimidines revealed strong antimicrobial activity against specific bacteria. The antibacterial activity data showed that compound 4 G had the strongest effect on Gram negative bacteria which is K.Pneumoniae whose minimum inhibitory concentration (MIC) is 28. Further, molecular docking studies were analyzed against synthetic cyanoimino pyrimidines to compare the experimental results. Also, produced good hydrogen bonding interactions. Availability of data and materials: All data generated or analyzed during this study are included in this published article.

Automated summary

The synthesis of 2-cyanoimino-6-aryl-4-(6-methoxynaphthalen-2-yl)-3,4-dihydro-1H-pyrimidines using 6-methoxy-2-naphthaldehyde and cyanoguanidine in the medium of aqueous sodium hydroxide in ethanol was documented. The antimicrobial testing of these compounds showed strong antibacterial activity, particularly against Gram negative bacteria. Molecular docking studies confirmed the presence of hydrogen bonding interactions between the synthetic cyanoimino pyrimidines and the target.