4.7 Article

Application of fluorescent nano-biosensor for the detection of cancer bio-macromolecular markers

Journal

POLYMER TESTING
Volume 115, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.polymertesting.2022.107746

Keywords

Cancer; Nano -materials; Cancer bio-macromolecular markers; Fluorescent nano-biosensors

Funding

  1. National Natural Science Founda- tion of China [32101039]
  2. Natural science foundation of Guangdong province of China [2022A1515011208]
  3. Natural Science Foundation of Tianjin [17JCYBJC43400]
  4. Major Innovative Research Team of Suzhou [ZXT2019007]

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Fluorescent sensors based on nano-materials have been widely used in cancer medical sensing research due to their unique properties. This article provides an overview of different nano-materials and their uses, as well as the principles and functions of fluorescent nano-biosensor detection for cancer bio-macromolecular markers. It also discusses the prospects and challenges of translating this diagnostic method into clinical application.
Fluorescent sensors developed based on nano-materials have penetrated into cancer medical sensing research due to their unique properties, such as high sensitivity, high specificity. The number of cancer patients has continued to rise in recent years, and the limitations of traditional cancer diagnosis methods can no longer meet the demand for accurate early cancer screening. Accurate identification of cancer bio-macromolecular markers can significantly improve early diagnosis and follow-up treatment. To this end, we provide an overview of the properties and uses of different nano-materials and detail the principles and functions of fluorescent nano-biosensor detection for different cancer bio-macromolecular markers. In addition, the prospects and chal-lenges of translating this convenient and visual diagnostic method into the clinical application are discussed.

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