Double functionalized haemocompatible silver nanoparticles control cell inflammatory homeostasis

Infection, trauma, and autoimmunity trigger tissue inflammation, often leading to pain and loss of function. Therefore, approaches to control inflammation based on nanotechnology principles are being developed in addition to available methods. The metal-based nanoparticles are particularly attractive due to the ease of synthesis, control over physicochemical properties, and facile surface modification with different types of molecules. Here, we report curcumin conjugated silver (Cur-Ag) nanoparticles synthesis, followed by their surface functionalization with isoniazid, tyrosine, and quercetin, leading to Cur-Ag-INH, Cur-Ag-Tyr, and Cur-Ag-Qrc nanoparticles, respectively. These nanoparticles possess radical scavenging capacity, haemocompatibility, and minimal cytotoxicity to macrophages. Furthermore, the nanoparticles inhibited the secretion of pro-inflammatory cytokines such as interleukin-6, tumor necrosis factor-alpha, and interleukin-1 beta from macrophages stimulated by lipopolysaccharide (LPS). The findings reveal that the careful design of surface corona of nanoparticles could be critical to increasing their efficacy in biomedical applications.

Automated summary

New approaches to control inflammation based on nanotechnology principles are being developed, and metal-based nanoparticles are particularly attractive due to their ease of synthesis and control over physicochemical properties. The careful design of surface corona of nanoparticles is critical to increasing their efficacy in biomedical applications.