4.7 Article

Furostanol saponins from Asparagus racemosus as potential hypoglycemic agents

Journal

PHYTOCHEMISTRY
Volume 201, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113286

Keywords

Asparagus racemosus; Asparagaceae; Type 2 diabetes mellitus (T2DM); GLUT4 translocation; AMPK signaling Pathway; Antihyperglycaemic; Furostanol saponin

Funding

  1. Department of Science and Technology
  2. UGC, New Delhi
  3. AcSIR, New Delhi

Ask authors/readers for more resources

Bioactivity guided phytochemical investigation led to the discovery of six new furostanol saponins from the roots of Asparagus racemosus. Among them, furoasparoside E showed significant potential in reducing blood glucose levels and may serve as a lead compound for the management of type 2 diabetes.
Bioactivity guided phytochemical investigation led to isolation of six undescribed furostanol saponins, furoasparoside A-F along with five known compounds, gallic acid, methyl gallate, quercetin-3-O-beta-glucopyranoside, liquiritigenin 4' -O-beta-apiofuranosyl-(1. 2)-beta-glucopyranoside and beta-glucogallin for the first time from the roots of Asparagus racemosus. Isolated saponins were screened for their antidiabetic potential in L6-GLUT4myc myotubes in vitro followed by an in vivo evaluation in streptozocin-induced diabetic rats and db/db mice. Furoasparoside E produced a notable decrease in the postprandial blood glucose profile, in leptin receptor-deficient db/db mice, type 2 diabetes model. The effect of furoasparoside E on GLUT4 translocation was found to be mediated by the AMPK-dependent signaling pathway in L6-GLUT4myc myotubes. Moreover, it emerged as a stable plant metabolite with higher bioavailability and efficacy in in vivo pharmacokinetic studies. Therefore, these studies indicated that furoasparoside E may serve as a propitious lead for the management of type 2 diabetes and its secondary complications from natural source.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available