Journal
PHYTOCHEMISTRY
Volume 203, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113376
Keywords
Chandonanthus birmensis Steph; Lophoziaceae; Liverwort; Cembrane diterpenoids; Cytotoxicity
Categories
Funding
- National Natural Science Foundation of China [81874293, 81630093]
- Major Basic Research Program of the Shandong Provincial Natural Science Foundation of China [ZR2019ZD26]
- National Key R & D Pro- gram of China [2019YFA0905700]
Ask authors/readers for more resources
A chemical investigation of the Chinese liverwort revealed five undescribed cembrane-type diterpenoids, along with known cembrane diterpenes, a fusicoccane-type diterpenoid, and a dolabellane-type diterpenoid. The structures were determined through comprehensive analysis and their cytotoxicity against cancer cell lines was evaluated.
A chemical investigation of the Chinese liverwort Chandonanthus birmensis Steph identified five undescribed cembrane-type diterpenoids, together with six known cembrane diterpenes, one fusicoccane-type diterpenoid, and a dolabellane-type diterpenoid. Their structures were established by comprehensive analysis of HRESIMS, NMR spectroscopic data, electronic circular dichroism (ECD) calculations and single-crystal X-ray diffraction analysis. Cytotoxicity tests of the isolated diterpenoids against five cancer cell lines (A2780, A549, H460, H460RT, and HeLa) revealed that several compounds showed moderate inhibitory effects with IC50 values ranging from 11.1 to 36.2 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
