4.8 Article

Thermodynamic Control of Activity Patterns in Cytoskeletal Networks

Journal

PHYSICAL REVIEW LETTERS
Volume 129, Issue 12, Pages -

Publisher

AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.129.128002

Keywords

-

Funding

  1. DOE BES Grant [DE-SC0019765]
  2. NSF [DGE-1746045]
  3. Luxembourg National Research Fund (FNR) [14389168]
  4. National Institutes of Health [R35 GM136381]
  5. National Science Foundation [MCB 2201235]
  6. Yen Fellowship
  7. U.S. Department of Energy (DOE) [DE-SC0019765] Funding Source: U.S. Department of Energy (DOE)

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This letter presents a thermodynamic control principle for structural transitions in a model cytoskeletal network, using methods from large deviation theory. The authors demonstrate that biasing the dynamics with respect to the work done by nonequilibrium components can effectively renormalize the interaction strength between these components, resulting in morphological transitions.
Biological materials, such as the actin cytoskeleton, exhibit remarkable structural adaptability to various external stimuli by consuming different amounts of energy. In this Letter, we use methods from large deviation theory to identify a thermodynamic control principle for structural transitions in a model cytoskeletal network. Specifically, we demonstrate that biasing the dynamics with respect to the work done by nonequilibrium components effectively renormalizes the interaction strength between such components, which can eventually result in a morphological transition. Our work demonstrates how a thermodynamic quantity can be used to renormalize effective interactions, which in turn can tune structure in a predictable manner, suggesting a thermodynamic principle for the control of cytoskeletal structure and dynamics.

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