Force-Regulated State Transitions of Growing Axons

Growing axons are one-dimensional active structures that are important for wiring the brain and repairing nerves. However, the biophysical mechanisms underlying the complex kinetics of growing axons remain elusive. Here, we develop a theoretical framework to recapitulate force-regulated states and their transitions in growing axons. We demonstrate a unique negative feedback mechanism that defines four distinct kinetic states in a growing axon, whose transitional boundaries depend on the interplay between cytoskeletal dynamics and axon-substrate adhesion. A phase diagram for axonal growth is formulated based on two dimensionless numbers.

Automated summary

In this study, a theoretical framework was developed to investigate the force-regulated states and transitions in growing axons. A unique negative feedback mechanism was discovered, defining four distinct kinetic states in the axon growth process. This research provides valuable insights into the understanding of axonal development.