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Lindsey H. M. te Brake et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)
Structure and function of multidrug and toxin extrusion proteins (MATEs) and their relevance to drug therapy and personalized medicine
Anne T. Nies et al.
ARCHIVES OF TOXICOLOGY (2016)
Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
Benjamin A. Kandel et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2016)
The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (squelching) SRC-1 coactivator
Lucie Hyrsova et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters
Zancong Shen et al.
CLINICAL DRUG INVESTIGATION (2016)
OCT1 Mediates Hepatic Uptake of Sumatriptan and Loss-of-Function OCT1 Polymorphisms Affect Sumatriptan Pharmacokinetics
J. Matthaei et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)
Inherited Variation in OATP1B1 Is Associated With Treatment Outcome in Acute Myeloid Leukemia
C. D. Drenberg et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)
DNA Methylation of ADME Genes
P. Fisel et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)
Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1
S. W. Yee et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)
Involvement of organic cation transporter 3 (Oct3/Slc22a3) in the bioavailability and pharmacokinetics of antidiabetic metformin in mice
Yoshiyuki Shirasaka et al.
DRUG METABOLISM AND PHARMACOKINETICS (2016)
Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation
Lucie Hyrsova et al.
DRUG METABOLISM REVIEWS (2016)
Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients
Linda Zaharenko et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2016)
Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites
Mitesh Patel et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2016)
In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes
Jacek R. Wisniewski et al.
JOURNAL OF PROTEOMICS (2016)
Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
Regina Krattinger et al.
LIFE SCIENCES (2016)
The Nonmetabolized β-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1 B1 and OATP1 B3
Shingen Misaka et al.
MOLECULAR PHARMACEUTICS (2016)
Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption
Ulrike M. Stamer et al.
PAIN (2016)
SLC22A1/OCT1 Genotype Affects O-desmethyltramadol Exposure in Newborn Infants
Maja Matic et al.
THERAPEUTIC DRUG MONITORING (2016)
Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes
Yan Liu et al.
XENOBIOTICA (2016)
The Impacts of SLC22A1 rs594709 and SLC47A1 rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients
Di Xiao et al.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2016)
Systematic meta-analyses of gene-specific genetic association studies in prostate cancer
Qiang Hao et al.
ONCOTARGET (2016)
Role of Hum an Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions
Cristina Arimany-Nardi et al.
FRONTIERS IN PHARMACOLOGY (2016)
Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes
Stefan Winter et al.
SCIENTIFIC REPORTS (2016)
Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species
Hong Shen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride
Daichi Fujita et al.
DRUG METABOLISM AND DISPOSITION (2016)
Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro
Yueping Zhang et al.
DRUG METABOLISM AND DISPOSITION (2016)
Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics
Li Wang et al.
DRUG METABOLISM AND DISPOSITION (2016)
Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells
Dianke Yu et al.
BIOCHEMICAL PHARMACOLOGY (2015)
Influence of HIV antiretrovirals on methadone N-demethylation and transport
Scott D. Campbell et al.
BIOCHEMICAL PHARMACOLOGY (2015)
Regorafenib Is Transported by the Organic Anion Transporter 1B1 and the Multidrug Resistance Protein 2
Hiroki Ohya et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2015)
Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid
Jin Fu Peng et al.
BIOMOLECULES & THERAPEUTICS (2015)
Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers
Mette Marie Hougaard Christensen et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2015)
Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure
Anna Vildhede et al.
JOURNAL OF PROTEOME RESEARCH (2015)
Polymorphisms of SLC22A9 (hOAT7) in Korean Females with Osteoporosis
Seong Kyu Ahn et al.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2015)
OCT1 and imatinib transport in CML: is it clinically relevant?
D. B. Watkins et al.
LEUKEMIA (2015)
Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1
Johanna J. Salomon et al.
MOLECULAR PHARMACEUTICS (2015)
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)
Xiaomin Liang et al.
MOLECULAR PHARMACEUTICS (2015)
Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination
Litaty Cephanoee Mbatchi et al.
PHARMACOGENOMICS (2015)
Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs
Venkata V. V. R. Marada et al.
PHARMACOLOGICAL RESEARCH (2015)
A Large Multiethnic Genome-Wide Association Study of Prostate Cancer Identifies Novel Risk Variants and Substantial Ethnic Differences
Thomas J. Hoffmann et al.
CANCER DISCOVERY (2015)
Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1
Tina Seitz et al.
GENOME MEDICINE (2015)
Organic anion transporter 2 transcript variant 1 shows broad ligand selectivity when expressed in multiple cell lines
Adam G. Hotchkiss et al.
FRONTIERS IN PHARMACOLOGY (2015)
Organic Anion Transporting Polypeptide-Mediated Transport of, and Inhibition by, Asunaprevir, an Inhibitor of Hepatitis C Virus NS3 Protease
T. Eley et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)
Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study
Tanja Dujic et al.
DIABETES (2015)
Expression of Drug Transporters and Drug Metabolizing Enzymes in the Bladder Urothelium in Man and Affinity of the Bladder Spasmolytic Trospium Chloride to Transporters Likely Involved in Its Pharmacokinetics
Maria Bexten et al.
MOLECULAR PHARMACEUTICS (2015)
What do drug transporters really do?
Sanjay K. Nigam
NATURE REVIEWS DRUG DISCOVERY (2015)
Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture
Lassina Badolo et al.
XENOBIOTICA (2015)
Genetic Variations of Drug Transporters Can Influence on Drug Response in Patients Treated with Docetaxel Chemotherapy
Jung Ran Choi et al.
CANCER RESEARCH AND TREATMENT (2015)
Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins
Jia Yin et al.
DRUG METABOLISM AND DISPOSITION (2015)
Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function
Maja Henjakovic et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)
Influence of SLC22A1 rs622342 genetic polymorphism on metformin response in South Indian type 2 diabetes mellitus patients
Gurusamy Umamaheswaran et al.
CLINICAL AND EXPERIMENTAL MEDICINE (2015)
Lysosomal Sequestration Determines Intracellular Imatinib Levels
Herman Burger et al.
MOLECULAR PHARMACOLOGY (2015)
Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin
Eugene C. Chen et al.
MOLECULAR PHARMACOLOGY (2015)
Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression
Hong Shen et al.
DRUG METABOLISM AND DISPOSITION (2015)
Inflammation-Associated MicroRNA-130b Down-Regulates Cytochrome P450 Activities and Directly Targets CYP2C9
Jessica K. Rieger et al.
DRUG METABOLISM AND DISPOSITION (2015)
Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions
Weiwei Jia et al.
DRUG METABOLISM AND DISPOSITION (2015)
The Poorly Membrane Permeable Antipsychotic Drugs Amisulpride and Sulpiride Are Substrates of the Organic Cation Transporters from the SLC22 Family
Joao N. Dos Santos Pereira et al.
AAPS JOURNAL (2014)
Verapamil decreases the glucose-lowering effect of metformin in healthy volunteers
Sung Kweon Cho et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2014)
Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach
N. Tsamandouras et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)
Taste of a Pill ORGANIC CATION TRANSPORTER-3 (OCT3) MEDIATES METFORMIN ACCUMULATION AND SECRETION IN SALIVARY GLANDS
Nora Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study
Atsushi Kudo et al.
JOURNAL OF GASTROENTEROLOGY (2014)
Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
Eve-Irene Lepist et al.
KIDNEY INTERNATIONAL (2014)
Interaction of Digitalis-Like Compounds with Liver Uptake Transporters NTCP, OATP1B1, and OATP1B3
Elnaz Gozalpour et al.
MOLECULAR PHARMACEUTICS (2014)
The organic cation transporter 3 (OCT3) as molecular target of psychotropic drugs: transport characteristics and acute regulation of cloned murine OCT3
Vivian Massmann et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2014)
Substrate- and Dose-Dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1
Yoshiyuki Shirasaka et al.
PHARMACEUTICAL RESEARCH (2014)
ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children
Raja Venkatasubramanian et al.
PHARMACOGENOMICS (2014)
Metformin resistance alleles in polycystic ovary syndrome: pattern and association with glucose metabolism
Natascha Schweighofer et al.
PHARMACOGENOMICS (2014)
Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine
Siyuan Sun et al.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2014)
Prediction of Organic Anion-Transporting Polypeptide 1B1-and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data
Annett Kunze et al.
DRUG METABOLISM AND DISPOSITION (2014)
The Contribution of Human OCT1, OCT3, and CYP3A4 to Nitidine Chloride-Induced Hepatocellular Toxicity
Liping Li et al.
DRUG METABOLISM AND DISPOSITION (2014)
Influences of Organic Cation Transporter Polymorphisms on the Population Pharmacokinetics of Metformin in Healthy Subjects
Hwa Yoon et al.
AAPS JOURNAL (2013)
Renal Transporters in Drug Development
Kari M. Morrissey et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)
Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration
Mladen V. Tzvetkov et al.
BIOCHEMICAL PHARMACOLOGY (2013)
Can specific OCT1 inhibitors be used to determine OCT1 transporter activity toward imatinib?
Herman Burger et al.
BLOOD (2013)
Population Pharmacokinetics of Metformin in Healthy Subjects and Patients with Type 2 Diabetes Mellitus: Simulation of Doses According to Renal Function
Janna K. Duong et al.
CLINICAL PHARMACOKINETICS (2013)
In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development
K. L. R. Brouwer et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)
Pharmacogenomic association between a variant in SLC47A1 gene and therapeutic response to metformin in type 2 diabetes
I. Tkac et al.
DIABETES OBESITY & METABOLISM (2013)
Identification of Novel Substrates and Structure-Activity Relationship of Cellular Uptake Mediated by Human Organic Cation Transporters 1 and 2
Ramon Hendrickx et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Reduced Renal Clearance of Cefotaxime in Asians with a Low-Frequency Polymorphism of OAT3 (SLC22A8)
Sook Wah Yee et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2013)
Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor
Elin M. Matsson et al.
MOLECULAR PHARMACEUTICS (2013)
Ischemia/Reperfusion-Inducible Protein Modulates the Function of Organic Cation Transporter 1 and Multidrug and Toxin Extrusion 1
Qing Li et al.
MOLECULAR PHARMACEUTICS (2013)
SLCO2B1 c.935G>A single nucleotide polymorphism has no effect on the pharmacokinetics of montelukast and aliskiren
Tuija Tapaninen et al.
PHARMACOGENETICS AND GENOMICS (2013)
The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance)
Lionel D. Lewis et al.
PHARMACOGENETICS AND GENOMICS (2013)
A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin
Mette M. H. Christensen et al.
PHARMACOGENETICS AND GENOMICS (2013)
OCT1 genetic variants influence the pharmacokinetics of morphine in children
Tsuyoshi Fukuda et al.
PHARMACOGENOMICS (2013)
Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3
L. Chen et al.
PHARMACOGENOMICS JOURNAL (2013)
Glucocorticoid receptor regulates organic cation transporter 1 (OCT1, SLC22A1) expression via HNF4α, upregulation in primary human hepatocytes
Alice Rulcova et al.
PHARMACOLOGICAL REPORTS (2013)
Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome
Vasily Stegaev et al.
RHEUMATOLOGY (2013)
Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1
Anne T. Nies et al.
GENOME MEDICINE (2013)
Hepatocyte Nuclear Factor 1 Regulates the Expression of the Organic Cation Transporter 1 via Binding to an Evolutionary Conserved Region in Intron 1 of the OCT1 Gene
Valerie P. O'Brien et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Expression Variability of Absorption, Distribution, Metabolism, Excretion-Related MicroRNAs in Human Liver: Influence of Nongenetic Factors and Association with Gene Expressions
Jessica K. Rieger et al.
DRUG METABOLISM AND DISPOSITION (2013)
In Vitro Characterization of Axitinib Interactions with Human Efflux and Hepatic Uptake Transporters: Implications for Disposition and Drug Interactions
Eric L. Reyner et al.
DRUG METABOLISM AND DISPOSITION (2013)
Transport Function and Transcriptional Regulation of a Liver-Enriched Human Organic Anion Transporting Polypeptide 2B1 Transcriptional Start Site Variant
Michael J. Knauer et al.
MOLECULAR PHARMACOLOGY (2013)
Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites
Brandon Swift et al.
DRUG METABOLISM AND DISPOSITION (2013)
Lamotrigine is a substrate for OCT1 in brain endothelial cells
David Dickens et al.
BIOCHEMICAL PHARMACOLOGY (2012)
The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1
Ali R. Saadatmand et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance
Michael Heise et al.
BMC CANCER (2012)
Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel
Anne-Joy M. de Graan et al.
CLINICAL CANCER RESEARCH (2012)
OATP1B1 Polymorphism as a Determinant of Erythromycin Disposition
C. S. Lancaster et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
Inter-individual Variability in OCT1 Expression and Its Relationship with OCT1 Genotype in Liver Samples from a Korean Population
Min-Hye Kim et al.
DRUG METABOLISM AND PHARMACOKINETICS (2012)
Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition
Laura B. Ramsey et al.
GENOME RESEARCH (2012)
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver
Evita van de Steeg et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose
Ichiro Ieiri et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2012)
In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug-Drug Interactions
Maria Karlgren et al.
PHARMACEUTICAL RESEARCH (2012)
Comments on Mougey et al. (2009): Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response. Pharmacogenet Genomics 19: 129-138
Xiaoyan Chu et al.
PHARMACOGENETICS AND GENOMICS (2012)
Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients
Linda Tarasova et al.
PHARMACOGENETICS AND GENOMICS (2012)
Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT3 antagonists tropisetron and ondansetron
M. V. Tzvetkov et al.
PHARMACOGENOMICS JOURNAL (2012)
Expression of Organic Anion Transporter 2 in the Human Kidney and Its Potential Role in the Tubular Secretion of Guanine-Containing Antiviral Drugs
Yaofeng Cheng et al.
DRUG METABOLISM AND DISPOSITION (2012)
Substrate- and pH-Specific Antifolate Transport Mediated by Organic Anion-Transporting Polypeptide 2B1 (OATP2B1-SLCO2B1)
Michele Visentin et al.
MOLECULAR PHARMACOLOGY (2012)
OAT2 catalyses efflux of glutamate and uptake of orotic acid
Christian Fork et al.
BIOCHEMICAL JOURNAL (2011)
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients
Sin-Chi Chew et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2011)
Expression of SLCO Transport Genes in Castration-Resistant Prostate Cancer and Impact of Genetic Variation in SLCO1B3 and SLCO2B1 on Prostate Cancer Outcomes
Jonathan L. Wright et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2011)
Rifampin Enhances the Glucose-Lowering Effect of Metformin and Increases OCT1 mRNA Levels in Healthy Participants
S. K. Cho et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Genetically Polymorphic OCT1: Another Piece in the Puzzle of the Variable Pharmacokinetics and Pharmacodynamics of the Opioidergic Drug Tramadol
M. V. Tzvetkov et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
Joerg Koenig et al.
DRUG METABOLISM AND DISPOSITION (2011)
Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent
Kazuya Takeuchi et al.
DRUG METABOLISM AND DISPOSITION (2011)
Regulation of drug transporter mRNA expression by interferon-γ in primary human hepatocytes
Marc Le Vee et al.
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2011)
Organic Cation Transporter 3: Expression in Failing and Nonfailing Human Heart and Functional Characterization
Thomas F. Solbach et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2011)
SLCO2B1 and SLCO1B3 May Determine Time to Progression for Patients Receiving Androgen Deprivation Therapy for Prostate Cancer
Ming Yang et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Transporters involved in the hepatic uptake of 99mTc-mebrofenin and indocyanine green
Wilmar de Graaf et al.
JOURNAL OF HEPATOLOGY (2011)
Development of imatinib and dasatinib resistance: dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1
Marta Gromicho et al.
LEUKEMIA & LYMPHOMA (2011)
Oxybutynin and trospium are substrates of the human organic cation transporters
Birger Wenge et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2011)
OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users
Matthijs L. Becker et al.
NEUROGENETICS (2011)
Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
Anne T. Nies et al.
PLOS ONE (2011)
Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity
Ute I. Schwarz et al.
PHARMACOGENETICS AND GENOMICS (2011)
The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c
Mette M. H. Christensen et al.
PHARMACOGENETICS AND GENOMICS (2011)
The impact of pharmacogenetics of metabolic enzymes and transporters on the pharmacokinetics of telmisartan in healthy volunteers
Akihiro Yamada et al.
PHARMACOGENETICS AND GENOMICS (2011)
Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake
Mikko Niemi et al.
PHARMACOLOGICAL REVIEWS (2011)
Effect of interferon-α2b on the expression of various drug-metabolizing enzymes and transporters in co-cultures of freshly prepared human primary hepatocytes
Cliff Chen et al.
XENOBIOTICA (2011)
DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
Elke Schaeffeler et al.
GENOME MEDICINE (2011)
Identification of genetic polymorphisms of human OAT1 and OAT2 genes and their relationship to hOAT2 expression in human liver
Ho Jung Shin et al.
CLINICA CHIMICA ACTA (2010)
The Role of Organic Anion-Transporting Polypeptides and Their Common Genetic Variants in Mycophenolic Acid Pharmacokinetics
N. Picard et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)
Pharmacokinetic and Pharmacodynamic Interactions Between the Immunosuppressant Sirolimus and the Lipid-Lowering Drug Ezetimibe in Healthy Volunteers
S. Oswald et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2010)
Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant
Tsuyoshi Minematsu et al.
DRUG METABOLISM AND DISPOSITION (2010)
Hepatitis C Virus-related Cirrhosis is a Major Determinant of the Expression Levels of Hepatic Drug Transporters
Ken Ogasawara et al.
DRUG METABOLISM AND PHARMACOKINETICS (2010)
Liver X Receptor α and Farnesoid X Receptor Are Major Transcriptional Regulators of OATP1B1
Henriette E. Meyer Zu Schwabedissen et al.
HEPATOLOGY (2010)
Rapid Modulation of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1, SLCO2B1) Function by Protein Kinase C-mediated Internalization
Kathleen Koeck et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Organic Cation Transporter 1 Polymorphisms Predict the Metabolic Response to Metformin in Women with the Polycystic Ovary Syndrome
Alessandra Gambineri et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2010)
Castration-Dependent Pharmacokinetics of Docetaxel in Patients With Prostate Cancer
Ryan M. Franke et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Gender Is an Important Determinant of the Disposition of the Loop Diuretic Torasemide
Ulrike Werner et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2010)
Organic Cation Transporters Modulate the Uptake and Cytotoxicity of Picoplatin, a Third-Generation Platinum Analogue
Swati S. More et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Uptake of Pramipexole by Human Organic Cation Transporters
Lei Diao et al.
MOLECULAR PHARMACEUTICS (2010)
Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem: Involvement of Human OATP Family in Apical Membrane Transport
Kazuhiko Kato et al.
MOLECULAR PHARMACEUTICS (2010)
The Human Organic Anion Transporter Genes OAT5 and OAT7 Are Transactivated by Hepatocyte Nuclear Factor-1α (HNF-1α)
Kerstin Klein et al.
MOLECULAR PHARMACOLOGY (2010)
Membrane transporters in drug development
Kathleen M. Giacomini et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
DNA Methylation Profiles of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines
Sayaka Ichihara et al.
PHARMACEUTICAL RESEARCH (2010)
Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response
Matthijs L. Becker et al.
PHARMACOGENETICS AND GENOMICS (2010)
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
Ligong Chen et al.
PHARMACOGENETICS AND GENOMICS (2010)
HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
Ruben C. Hartkoorn et al.
PHARMACOGENETICS AND GENOMICS (2010)
Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation
Curtis D. Klaassen et al.
PHARMACOLOGICAL REVIEWS (2010)
The Prostaglandin Transporter OATP2A1 Is Expressed in Human Ocular Tissues and Transports the Antiglaucoma Prostanoid Latanoprost
Michaela E. Kraft et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
Transport of guanidine compounds by human organic cation transporters, hOCT1 and hOCT2
Naoko Kimura et al.
BIOCHEMICAL PHARMACOLOGY (2009)
A Comparison of Uptake of Metformin and Phenformin Mediated by hOCT1 in Human Hepatocytes
Yoshihisa Sogame et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2009)
Expression of Human Organic Cation Transporter 3 in Kidney Carcinoma Cell Lines Increases Chemosensitivity to Melphalan, Irinotecan, and Vincristine
Volodymyr Shnitsar et al.
CANCER RESEARCH (2009)
The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin
M. V. Tzvetkov et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2009)
Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study
Kaixin Zhou et al.
DIABETES (2009)
Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6
Marc Le Vee et al.
DRUG METABOLISM AND DISPOSITION (2009)
Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
Xin Ming et al.
DRUG METABOLISM AND DISPOSITION (2009)
Involvement of Human Organic Cation Transporter 1 in the Hepatic Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel, Small Molecule Survivin Suppressant
Megumi Iwai et al.
DRUG METABOLISM AND DISPOSITION (2009)
Differential Regulation of Drug Transporter Expression by Hepatocyte Growth Factor in Primary Human Hepatocytes
Marc Le Vee et al.
DRUG METABOLISM AND DISPOSITION (2009)
Expression of Organic Cation Transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) Is Affected by Genetic Factors and Cholestasis in Human Liver
Anne T. Nies et al.
HEPATOLOGY (2009)
Transport of Lamivudine [(-)-β-L-2′,3′-Dideoxy-3′-thiacytidine] and High-Affinity Interaction of Nucleoside Reverse Transcriptase Inhibitors with Human Organic Cation Transporters 1, 2, and 3
Gerard Minuesa et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease
David-Alexandre Tregouet et al.
NATURE GENETICS (2009)
The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs
Sarah Shugarts et al.
PHARMACEUTICAL RESEARCH (2009)
Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response
Edward B. Mougey et al.
PHARMACOGENETICS AND GENOMICS (2009)
Impact of regulatory polymorphisms in organic anion transporter genes in the human liver
Masayo Aokia et al.
PHARMACOGENETICS AND GENOMICS (2009)
Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus
M. L. Becker et al.
PHARMACOGENOMICS JOURNAL (2009)
Regulation of basal core promoter activity of human organic cation transporter 1 (OCT1/SLC22A1)
Moto Kajiwara et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia
Kazuma Kiyotani et al.
CANCER SCIENCE (2008)
Interaction of imatinib with human organic ion carriers
Shuiying Hu et al.
CLINICAL CANCER RESEARCH (2008)
Influence of Solute Carriers on the Pharmacokinetics of CYP3A4 Probes
R. M. Franke et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Significance of Organic Cation Transporter 3 (SLC22A3) Expression for the Cytotoxic Effect of Oxaliplatin in Colorectal Cancer
Sachiko Yokoo et al.
DRUG METABOLISM AND DISPOSITION (2008)
Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection
Norma Jung et al.
DRUG METABOLISM AND DISPOSITION (2008)
Decreased expression of cytochromes p450 1A2, 2E1, and 3A4 and drug transporters Na+-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients
Kenya Nakai et al.
DRUG METABOLISM AND DISPOSITION (2008)
Identification and Species Similarity of OATP Transporters Responsible for Hepatic Uptake of beta-Lactam Antibiotics
Masanori Nakakariya et al.
DRUG METABOLISM AND PHARMACOKINETICS (2008)
Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs
Anne T. Nies et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Pharmacokinetics of the Oral Direct Renin Inhibitor Aliskiren in Combination With Digoxin, Atorvastatin, and Ketoconazole in Healthy Subjects: The Role of P-Glycoprotein in the Disposition of Aliskiren
Sujata Vaidyanathan et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2008)
Analysis of regulatory polymorphisms in organic ion transporter genes (SLC22A) in the kidney
Ken Ogasawara et al.
JOURNAL OF HUMAN GENETICS (2008)
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1
Gustav Ahlin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP
Cheryl D. Cropp et al.
MOLECULAR PHARMACOLOGY (2008)
Multiple newly identified loci associated with prostate cancer susceptibility
Rosalind A. Eeles et al.
NATURE GENETICS (2008)
SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1
Stefan Oswald et al.
PHARMACOGENETICS AND GENOMICS (2008)
The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent:: the contribution of transporting activity changes by SLCO1B1*15
Jian Wei Deng et al.
PHARMACOGENETICS AND GENOMICS (2008)
cis-diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent:: Uptake, structure, function, and prospects
Katherine S. Lovejoy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Investigation of the inhibitory effects of various drugs on the hepatic uptake of fexofenadine in humans
Soichiro Matsushima et al.
DRUG METABOLISM AND DISPOSITION (2008)
Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics
Y. Shu et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)
Anne T. Nies et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2008)
Novel mutations of the extraneuronal monoamine transporter gene in children and adolescents with obsessive-compulsive disorder
Andreas Lazar et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2008)
Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1β
Marc Le Vee et al.
DRUG METABOLISM AND DISPOSITION (2008)
Multiple human Isoforms of drug transporters contribute to the hepatic and renal transport of olmesartan, a selective antagonist of the angiotensin II AT1-Receptor
Akihiro Yamada et al.
DRUG METABOLISM AND DISPOSITION (2007)
Hepatocyte nuclear factor 1 alpha is a factor responsible for the interindividual variation of OATP1B1 mRNA levels in adult Japanese livers
Tomomi Furihata et al.
PHARMACEUTICAL RESEARCH (2007)
Bosentan is a substrate of human OATP1B1 and OATP1B3:: Inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin a, rifampicin, and sildenafil
Alexander Treiber et al.
DRUG METABOLISM AND DISPOSITION (2007)
Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3
Johannes Noe et al.
DRUG METABOLISM AND DISPOSITION (2007)
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
Yan Shu et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate
Ho Jung Shin et al.
HEPATOLOGY (2007)
Human organic cation transporter (OCT1 and OCT2) gene polymorphisms and therapeutic effects of metformin
Eriko Shikata et al.
JOURNAL OF HUMAN GENETICS (2007)
Variants in the SLCO1B3 gene: Interethnic distribution and association with paclitaxel pharmacokinetics
N. F. Smith et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
Role of human hepatocyte nuclear factor 4 alpha in the expression of drug-metabolizing enzymes and transporters in human Hepatocytes assessed by use of small interfering RNA
Yoshiteru Kamiyama et al.
DRUG METABOLISM AND PHARMACOKINETICS (2007)
Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart
Markus Grube et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)
Atsushi Yonezawa et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes
Emilie Jigorel et al.
DRUG METABOLISM AND DISPOSITION (2006)
Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder
Nagisa Aoyama et al.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2006)
Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans
Wakaba Yamashiro et al.
DRUG METABOLISM AND DISPOSITION (2006)
Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers
Lichuan Liu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans
Naoki Ishiguro et al.
DRUG METABOLISM AND DISPOSITION (2006)
The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4α
M Saborowski et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
OATP1B1, OATP1B3, and MRP2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker
R Nakagomi-Hagihara et al.
DRUG METABOLISM AND DISPOSITION (2006)
Effects of organic anion transporting polypeptide IBI haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril
Kazuya Maeda et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2006)
Molecular characterization and inhibition of amanitin uptake into human hepatocytes
K Letschert et al.
TOXICOLOGICAL SCIENCES (2006)
Drug and bile acid transporters in rosuvastatin hepatic uptake: Function, expression, and pharmacogenetics
Richard H. Ho et al.
GASTROENTEROLOGY (2006)
Farnesoid X receptor, hepatocyte nuclear factors 1α and 3β are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene
H Ohtsuka et al.
JOURNAL OF GASTROENTEROLOGY (2006)
Polymorphisms and linkage disequilibrium of the OATP8 (OATP1B3) gene in Japanese subjects
Masayuki Tsujimoto et al.
DRUG METABOLISM AND PHARMACOKINETICS (2006)
Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
J Müller et al.
BIOCHEMICAL PHARMACOLOGY (2005)
Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)
DL Bourdet et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)] -: Rapid Communication
G Xu et al.
KIDNEY INTERNATIONAL (2005)
A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters
H Tahara et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans
M Shimizu et al.
DRUG METABOLISM AND DISPOSITION (2005)
Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells
K Kopplow et al.
MOLECULAR PHARMACOLOGY (2005)
Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel
NF Smith et al.
CANCER BIOLOGY & THERAPY (2005)
IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity
W Jiang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells
Y Kameyama et al.
PHARMACOGENETICS AND GENOMICS (2005)
Hepatic uptake of the novel antifungal agent caspofungin
P Sandhu et al.
DRUG METABOLISM AND DISPOSITION (2005)
The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4α and suppressed by bile acids
K Popowski et al.
MOLECULAR PHARMACOLOGY (2005)
Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B
H Satoh et al.
DRUG METABOLISM AND DISPOSITION (2005)
Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: In vitro evidence and effect of single nucleotide polymorphisms
T Nozawa et al.
DRUG METABOLISM AND DISPOSITION (2005)
Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: Implications for understanding troglitazone hepatotoxicity
T Nozawa et al.
DRUG METABOLISM AND DISPOSITION (2004)
The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3β in hepatocellular carcinoma
SR Vavricka et al.
JOURNAL OF HEPATOLOGY (2004)
Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
M Hirano et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs
H Hasannejad et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)
M Niemi et al.
PHARMACOGENETICS (2004)
Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)
K Letschert et al.
PHARMACOGENETICS (2004)
Regulation of the human organic cation transporter hOCT1
G Ciarimboli et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2004)
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes:: Consequences for pravastatin pharmacokinetics
Y Nishizato et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2003)
Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1
Y Shu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A
Y Shitara et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation
RG Tirona et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
H Kojima et al.
JOURNAL OF HEPATOLOGY (2003)
Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3)
A Lazar et al.
JOURNAL OF HUMAN GENETICS (2003)
Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences
R Kerb et al.
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Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
SR Vavricka et al.
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Human organic anion transporters and human organic cation transporters mediate renal antiviral transport
M Takeda et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Catalog of 238 variations among six human genes encoding solute carriers (hSLCs) in the Japanese population
S Saito et al.
JOURNAL OF HUMAN GENETICS (2002)
Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems
F Martel et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2001)
Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1α
D Jung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Polymorphisms in OATP-C -: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans
RG Tirona et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
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GA Kullak-Ublick et al.
GASTROENTEROLOGY (2001)
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A Iida et al.
JOURNAL OF HUMAN GENETICS (2001)
Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
J König et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family
I Tamai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
J Konig et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2000)
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