☆ 4.7 Article

Long non-coding RNA/epithelial-mesenchymal transition axis in human cancers: Tumorigenesis, chemoresistance, and radioresistance

PHARMACOLOGICAL RESEARCH (2022)

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Magnetite and bismuth sulfide Janus heterostructures as radiosensitizers for in vivo enhanced radiotherapy in breast cancer

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Summary: This study developed a novel bimetallic nanoradiosensitizer, Bi2S3-Fe3O4, which exhibited strong radiosensitizing ability through the generation of reactive oxygen species. The surface of the nanoparticles was coated with bovine serum albumin and conjugated with folic acid to improve stability, cellular uptake, and tumor targeting. In vivo experiments showed that Bi2S3@BSA-Fe3O4-FA effectively eradicated tumors without causing toxicity in healthy tissues.

BIOMATERIALS ADVANCES (2022)

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Article Medicine, General & Internal

LncRNA LINC01857 drives pancreatic adenocarcinoma progression via modulating miR-19a-3p/SMOC2

Yeting Lu et al.

Summary: This study reveals that LINC01857 promotes malignant phenotypes in pancreatic ductal adenocarcinoma cells by upregulating SMOC2 through interacting with miR-19a-3p.

CLINICS (2022)

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Article Oncology

lncRNA RP11-10A14.5: a potential prognosis biomarker for LUAD through regulation on proliferation and metastasis

Zhijie Lin et al.

Summary: This study found that RP11-10A14.5 is closely associated with clinical stage and prognosis of lung cancer, and may serve as a diagnostic and prognostic predictor for LUAD. Experimental results show that RP11-10A14.5 can promote the growth, invasion, and metastasis of lung cancer cells, and enhance the survival ability of metastatic cells by affecting cell adhesion and apoptosis.

DISCOVER ONCOLOGY (2022)

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Article Developmental Biology

A novel mechanism of the lncRNA PTTG3P/miR-142-5p/JAG1 axis modulating tongue cancer cell phenotypes through the Notch1 signaling

Tonghan Zhang et al.

Summary: Tongue cancer is known to be influenced by the oncogenic effect of JAG1 through the JAG1/Notch pathway. This study discovers the role of the lncRNA PTTG3P in tongue cancer and its positive correlation with JAG1. PTTG3P affects the proliferation and migration abilities of tongue tumor cells by directly binding to miR-142-5p and regulating the expression of JAG1. The PTTG3P/miR-142-5p axis plays an important role in modulating the aggressiveness of tongue cancer through the JAG1/Notch signaling pathway.

CELLS & DEVELOPMENT (2022)

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Article Toxicology

Inhibition of lncRNA RET enhances radio-sensitivity of tumor cells via miR-3179/Slug/PTEN axis

Xinxin Liang et al.

Summary: The long noncoding RNA RET is involved in the radiotherapy resistance of several cancers. RET plays a role in cancer cell proliferation, apoptosis, and radiation resistance by regulating various genes and signaling pathways.

TOXICOLOGY RESEARCH (2022)

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Article Cell Biology

LncRNA SAMMSON Knockdown Inhibits the Malignancy of Glioblastoma Cells by Inactivation of the PI3K/Akt Pathway

Hongzao Ni et al.

Summary: LncRNA SAMMSON is highly expressed in GBM tissues and cells, and its knockdown suppresses cell viability, hinders cell invasion, promotes apoptosis, and inhibits the PI3K/Akt pathway in GBM cells. Rescue assays demonstrate that activation of the PI3K/Akt pathway reverses the effects of SAMMSON knockdown in GBM cells. Overall, SAMMSON knockdown inhibits the malignancy of GBM cells by inactivating the PI3K/Akt pathway.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

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Article Cell Biology

lncRNA PVT1 promotes the migration of gastric cancer by functioning as ceRNA of miR-30a and regulating Snail

Lina Wang et al.

Summary: This study revealed that high expression of PVT1 is associated with poor prognosis in GC patients and can promote EMT process and metastasis of GC cells. PVT1 binds with miR-30a to increase Snail expression, affecting the migration of GC cells.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Gastroenterology & Hepatology

LncRNA miR503HG inhibits epithelial-mesenchymal transition and angiogenesis in hepatocellular carcinoma by enhancing PDCD4 via regulation of miR-15b

Shengping Song et al.

Summary: LncRNA miR503HG inhibits EMT and angiogenesis in hepatocellular carcinoma through the miR-15b/PDCD4 axis.

DIGESTIVE AND LIVER DISEASE (2021)

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Article Biochemistry & Molecular Biology

lncRNA-POIR promotes epithelial-mesenchymal transition and suppresses sorafenib sensitivity simultaneously in hepatocellular carcinoma by sponging miR-182-5p

Bryan Wei Chen et al.

Summary: This study revealed the crucial role of lncRNA-POIR in promoting EMT progression and suppressing SOR sensitivity in HCC cells by interacting with miR-182-5p. The findings suggest that lncRNA-POIR has the potential to serve as a promising predictor of SOR response and a therapeutic target for HCC treatment in the future.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

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Article Biotechnology & Applied Microbiology

lncRNA SNHG11 Promotes Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway and Oncogenic Autophagy

Qiong Wu et al.

Summary: SNHG11 serves as an oncoIncRNA in gastric cancer by promoting oncogenic autophagy and malignant behaviors through both the miR-483-3p/miR-1276 pathway and the Wnt/β-catenin pathway. Its upregulation is transcriptionally induced by TCF7L2 and may be a potential prognostic and therapeutic target for gastric cancer.

MOLECULAR THERAPY (2021)

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Article Cell Biology

Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis

Yangyang Liu et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy

Zhaowu Ma et al.

Summary: Hypoxia plays a crucial role in the tumor microenvironment, correlating with tumor metastasis and prognosis. HIF-1α, a key molecule, is involved in multiple crucial steps in the metastatic cascade. Currently, researchers are focusing on potential pharmacological interventions and developing HIF-1 inhibitors to block tumor metastasis.

ANTIOXIDANTS & REDOX SIGNALING (2021)

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Review Biochemistry & Molecular Biology

Designing precision medicine panels for drug refractory cancers targeting cancer stemness traits

Sudha Warrier et al.

Summary: Cancer stem cells, a minor subpopulation of cells within tumors, play a crucial role in tumor metastasis and relapse. Understanding different CSC markers in various cancer subtypes can aid in predicting and treating resistant cancer stem cell populations for better prognosis and targeted therapy.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Biotechnology & Applied Microbiology

Circ_0001247 functions as a miR-1270 sponge to accelerate cervical cancer progression by up-regulating ZEB2 expression level

Wenshuang Wang et al.

Summary: The study found that circ_0001247 may be an oncogenic circRNA in cervical cancer, promoting the progression of cervical cancer by sponging miR-1270 to upregulate ZEB2 expression level.

BIOTECHNOLOGY LETTERS (2021)

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Article Biochemistry & Molecular Biology

LncRNA AL592284.1 facilitates proliferation and metastasis of cervical cancer cells via miR-30a-5p/Vimentin/EMT axis

Jing Zhang et al.

Summary: The study reveals that the expression of AL592284.1 is increased in cervical cancer, and it promotes the proliferation, migration, and invasion of cancer cells through regulating the miR-30a-5p/Vimentin axis. Inhibiting AL592284.1 may be a potential treatment strategy for cervical cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Oncology

A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis

Priyanka Kulkarni et al.

Summary: The study reveals that the interaction between lncTCL6 and miR-155 plays a crucial role in regulating the Src-Akt-EMT network in clear cell renal cell carcinoma, impacting disease progression and metastasis. Patients with higher lncTCL6 expression and lower miR-155 expression have a better survival probability, offering a promising therapeutic target for renal cancer treatment.

CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

LncRNA SNHG6 knockdown inhibits cisplatin resistance and progression of gastric cancer through miR-1297/BCL-2 axis

Jiazhan Mei et al.

Summary: The study revealed that lncRNA SNHG6 has inhibitory effects on DDP resistance and progression of GC by sponging miR-1297 and regulating BCL-2 expression.

BIOSCIENCE REPORTS (2021)

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Article Oncology

LncRNA MCF2L-AS1 aggravates the malignant development of colorectal cancer via targeting miR-105-5p/RAB22A axis

Wencheng Kong et al.

Summary: MCF2L-AS1 accelerates the malignant development of CRC cells by targeting the miR-105-5p/RAB22A axis. High expression of MCF2L-AS1 in CRC cells enhances proliferation, migration, invasion, and EMT process. MCF2L-AS1 acts by sponging miR-105-5p and targeting RAB22A in CRC cells.

BMC CANCER (2021)

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Article Biochemistry & Molecular Biology

lncRNA PCAT1 might coordinate ZNF217 to promote CRC adhesion and invasion through regulating MTA2/MTA3/Snai1/E-cadherin signaling

Shulong Zhang et al.

Summary: This study found that the expression of exosomal lncRNA PCAT1 is significantly increased in CRC tissues and cell lines, and overexpression of PCAT1 may lead to upregulation of ZNF217, which regulates the EMT-related signaling pathway involving MTA2/MTA3/Snai1/Ecadherin.

CELLULAR AND MOLECULAR BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC

Yang Xia et al.

Summary: This study demonstrated that thalidomide inhibits NSCLC angiogenesis and immune evasion by targeting FGD5-AS1. FGD5-AS1 regulates the expression of PD-L1 and VEGFA through the miR-454-3p/ZEB1 axis, affecting the PD-1/PD-L1 checkpoint and exerting anti-tumor effects.

CHEMICO-BIOLOGICAL INTERACTIONS (2021)

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Review Biochemistry & Molecular Biology

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

Xiaoxu Wei et al.

Summary: Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.

MOLECULAR CANCER (2021)

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Article Plant Sciences

Berberine regulates the Notch1/PTEN/PI3K/AKT/mTOR pathway and acts synergistically with 17-AAG and SAHA in SW480 colon cancer cells

Ge Li et al.

Summary: BBR was found to have anti-colon cancer effects through CMAP analysis, impacting cell proliferation and apoptosis through multiple pathways. It showed synergistic effects when used in combination with Hsp90 and HDAC inhibitors.

PHARMACEUTICAL BIOLOGY (2021)

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Article Cell Biology

Long non-coding RNA LINC00665 promotes gemcitabine resistance of Cholangiocarcinoma cells via regulating EMT and stemness properties through miR-424-5p/BCL9L axis

Min Lu et al.

Summary: The study showed that LINC00665 plays a crucial role in gemcitabine resistance of CCA cells by regulating BCL9L expression, leading to modulation of EMT, stemness, and Wnt/β-Catenin activation.

CELL DEATH & DISEASE (2021)

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Review Biochemistry & Molecular Biology

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Mahshid Deldar Abad Paskeh et al.

Summary: The key to cancer treatment lies in understanding the unique mechanisms of cancer development, particularly in targeting cancer stem cells. Dietary agents play a crucial role in suppressing cancer stemness and enhancing treatment sensitivity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Long Non-Coding RNA ANRIL as a Potential Biomarker of Chemosensitivity and Clinical Outcomes in Osteosarcoma

Adam M. Lee et al.

Summary: Osteosarcoma has a poor prognosis due to chemo-resistance and/or metastases. Increasing evidence shows that long non-coding RNAs (lncRNAs) can play an important role in drug sensitivity and cancer metastasis. ANRIL may serve as a potential biomarker for chemosensitivity and prognosis in osteosarcoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

LncRNA MALAT1 Facilitates Ovarian Cancer Progression through Promoting Chemoresistance and Invasiveness in the Tumor Microenvironment

Tsui-Lien Mao et al.

Summary: The upregulation of MALAT1 in epithelial ovarian cancer is associated with activation of tumor-related signaling pathways, influencing apoptosis, inflammation, proliferation, and invasion processes in cancer cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biotechnology & Applied Microbiology

Silencing of long non-coding RNA HCP5 inhibits proliferation, invasion, migration, and promotes apoptosis via regulation of miR-299-3p/SMAD5 axis in gastric cancer cells

Derong Yin et al.

Summary: The study indicates that the high expression of lncRNA HCP5 is associated with the development of gastric cancer, and its silencing can inhibit the proliferation, invasion, and migration of GC cells. Additionally, miR-299-3p and SMAD5 play crucial roles in regulating this process.

BIOENGINEERED (2021)

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Article Oncology

HCP5 Promotes Proliferation and Contributes to Cisplatin Resistance in Gastric Cancer Through miR-519d/HMGA1 Axis

Zhu Zhang et al.

Summary: HCP5 promoted proliferation and contributed to cisplatin resistance in gastric cancer cells through the miR-519d/HMGA1 axis.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Medicine, Research & Experimental

FAM83A promotes proliferation and metastasis via Wnt/β-catenin signaling in head neck squamous cell carcinoma

Huan Ji et al.

Summary: This study identifies FAM83A as an oncogene of HNSCC with overexpression significantly associated with tumor size, lymph node status, and clinical tumor stages. FAM83A promotes HNSCC cell growth and metastasis by inducing EMT through activation of the Wnt/beta-catenin signaling pathway. Knockdown of FAM83A suppresses tumor growth and distant metastasis in xenograft animal models of HNSCC.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Review Oncology

Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pie-ces of an Incomplete Puzzle for Lung Cancer Therapy

Milad Ashrafizadeh et al.

Summary: Long non-coding RNAs (lncRNAs) play a crucial role in regulating epithelial-to-mesenchymal transition (EMT) in lung cancer. Some lncRNAs have tumor-suppressing effects by inhibiting EMT and metastasis, while others have tumor-promoting effects by triggering EMT and enhancing migration of cancer cells. Targeting lncRNAs could be important in controlling the migration of lung cancer cells.

CURRENT CANCER DRUG TARGETS (2021)

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Article Biochemistry & Molecular Biology

Exosome-mediated transfer of lncRNA HCG18 promotes M2 macrophage polarization in gastric cancer

Lin Xin et al.

Summary: This study demonstrated that exosomal lncRNA HCG18 regulates M2 macrophage polarization in gastric cancer by binding to miR-875-3p, which then binds to KLF4. The upregulation of KLF4 expression by exosomal lncRNA HCG18 facilitates M2 macrophage polarization and alleviates gastric cancer development.

MOLECULAR IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

LncRNA BACE1-AS enhances the invasive and metastatic capacity of hepatocellular carcinoma cells through mediating miR-377-3p/CELF1 axis

Chunjiang Liu et al.

Summary: The study demonstrated that lncRNA BACE1-AS was upregulated in HCC, promoting invasion and metastasis of hepatocellular carcinoma cells by modulating the miR-377-3p/CELF1 axis and contributing to the EMT pathway. BACE1-AS could be a potential biomarker in HCC for future treatment.

LIFE SCIENCES (2021)

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Article Oncology

lncRNA DQ786243 promotes hepatocellular carcinoma cell invasion and proliferation by regulating the miR-15p-5p/Wnt3A axis

Zewei Lin et al.

Summary: The study reveals that lncRNA DQ786243 (lncDQ) plays a role in promoting hepatocellular carcinoma (HCC) progression by modulating the expression of miR-15b-5p and Wnt3A. Low levels of miR-15b-5p are associated with poor prognoses for HCC patients, while silencing lncDQ can attenuate proliferation and invasion of liver cancer and HCC cells.

MOLECULAR MEDICINE REPORTS (2021)

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Article Pharmacology & Pharmacy

Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467

Shumei Xiao et al.

Summary: LINC01224 has been shown to promote tumor progression and cisplatin resistance in NSCLC by sponging miR-2467. Studies confirmed the nucleotide interaction between LINC01224 and miR-2467, demonstrating effects in cell and in vivo experiments.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2021)

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Article Biotechnology & Applied Microbiology

LncRNA MCTP1-AS1 Regulates EMT Process in Endometrial Cancer by Targeting the miR-650/SMAD7 Axis

Qin Gao et al.

Summary: In this study, it was found that MTCP1-AS1 was downregulated in endometrial cancer (EC) tissues and cell lines. Overexpression of MTCP1-AS1 inhibited cell proliferation, migration, invasion and epithelial to mesenchymal transition (EMT) process in EC cells, potentially through targeting the miR-650/SMAD7 axis.

ONCOTARGETS AND THERAPY (2021)

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Article Cell Biology

LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

Xiao Tan et al.

Summary: The interaction between LncRNA and RNA-binding protein (RBPs) is crucial in regulating tumor progression. SNHG1, a newly discovered lncRNA, competitively interacts with hnRNPL to inhibit E-cadherin translation, ultimately promoting metastasis in prostate cancer (PCa).

CELL DEATH & DISEASE (2021)

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Article Oncology

The lncRNA XIST/miR-125b-2-3p axis modulates cell proliferation and chemotherapeutic sensitivity via targeting Wee1 in colorectal cancer

Zhao-lei Zeng et al.

Summary: miR-125b-2-3p is under-expressed in colorectal cancer, and its over-expression is associated with lower proliferation rates and fewer metastases. High levels of miR-125b-2-3p significantly improve chemotherapeutic sensitivity in colorectal cancer. Additionally, lncRNA XIST absorbs miR-125b-2-3p to regulate WEE1 expression, promoting metastasis in colorectal cancer.

CANCER MEDICINE (2021)

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Article Oncology

Role of lncRNA NR2F1-AS1 and lncRNA H19 Genes in Hepatocellular Carcinoma and Their Effects on Biological Function of Huh-7

Wen-Chao Ji et al.

Summary: This study revealed the abnormal expression of lncRNA NR2F1-AS1 and H19 genes in HCC, which can promote apoptosis and inhibit cell growth. Additionally, it was found that they can suppress the EMT process of Huh-7 cells.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Oncology

SNHG1 knockdown upregulates miR-376a and downregulates FOXK1/Snail axis to prevent tumor growth and metastasis in HCC

Fanzhi Meng et al.

Summary: Long non-coding RNAs (lncRNAs), microRNAs (miRNAs or miRs), and genes play important roles in cancer progression. Through experiments on HCC cells and nude mouse models, it was found that knockdown of SNHG1 had anti-tumor activity in HCC by regulating the SNHG1/miR-376/FOXK1/Snail axis and delaying cancer progression. Targeting SNHG1 may be a potential therapeutic strategy for HCC.

MOLECULAR THERAPY-ONCOLYTICS (2021)

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Article Oncology

Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma

Shuwei Chen et al.

Summary: The study revealed that FOXD1 is upregulated in oral squamous cell cancer (OSCC) and promotes chemoresistance and epithelial-mesenchymal transition (EMT), with the CYTOR/LPP axis playing a key role in this process. FOXD1 may serve as a potential prognostic marker and therapeutic target for overcoming chemotherapy resistance in OSCC.

CANCER LETTERS (2021)

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Article Cell Biology

LINC01451 drives epithelial-mesenchymal transition and progression in bladder cancer cells via LIN28/TGF-β/Smad pathway

Heng Shi et al.

Summary: This study identified LINC01451 as a functional lncRNA with significantly higher expression in BLCa tissues compared to normal tissues. LINC01451 was found to directly interact with LIN28A and LIN28B, promoting proliferation, invasion, and metastasis of BLCa. Mechanistically, LINC01451 was shown to facilitate epithelial-mesenchymal transition through activating the TGF-beta/Smad signaling pathway, leading to the progression of BLCa.

CELLULAR SIGNALLING (2021)

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Article Biotechnology & Applied Microbiology

LncRNA-NNT-AS1 contributes to the progression of glioma by miR-582-5p/EZH2 axis

Tonglin Pan et al.

Summary: The study found that NNT-AS1 was up-regulated in glioma cells and promoted malignant behaviors through the miR-582-5p/EZH2 axis.

CYTOTECHNOLOGY (2021)

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Article Oncology

CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression

Qing Liao et al.

Summary: LASP1 and CCT8 can interact with each other in CRC cells and promote tumor progression. CCT8 promotes the growth and metastasis of CRC by inhibiting the entry of WTp53 into the nucleus. High expression of CCT8 leads to worse overall survival in CRC patients.

ONCOGENESIS (2021)

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Article Biotechnology & Applied Microbiology

CRTAC1 (Cartilage acidic protein 1) inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) process in bladder cancer by downregulating Yin Yang 1 (YY1) to inactivate the TGF-β pathway

Jianghua Yang et al.

Summary: CRTAC1 is down-regulated in bladder cancer and inhibits malignant behaviors of bladder cancer cells by targeting YY1 to inactivate the TGF-beta pathway.

BIOENGINEERED (2021)

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Article Biotechnology & Applied Microbiology

LncRNA DDX11 antisense RNA 1 promotes EMT process of esophageal squamous cell carcinoma by sponging miR-30d-5p to regulate SNAI1/ZEB2 expression and Wnt/β-catenin pathway

Yanli Guo et al.

Summary: The research highlights the critical role of DDX11-AS1 in ESCC, demonstrating its involvement in promoting ESCC progression by regulating the expression of miR-30d-5p and SNAI1/ZEB2, as well as activating the Wnt/beta-catenin pathway.

BIOENGINEERED (2021)

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Article Genetics & Heredity

CD73 Severed as a Potential Prognostic Marker and Promote Lung Cancer Cells Migration via Enhancing EMT Progression

Zhao-wei Gao et al.

Summary: CD73 expression is higher in lung adenocarcinoma (LUAD) compared to normal tissues and may be a poor prognostic marker for lung squamous cell carcinoma (LUSC) patients. CD73 plays a role in promoting proliferation and migration in LUAD cells, suggesting it as a potential therapeutic target for LUAD.

FRONTIERS IN GENETICS (2021)

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Article Oncology

LncRNA PAINT is associated with aggressive prostate cancer and dysregulation of cancer hallmark genes

Md Faqrul Hasan et al.

Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Oncology

Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway

Loukik Arora et al.

Summary: STAT3 is a major oncogenic transcription factor that is constitutively activated in various human cancers, including HCC and MM. Tris DBA, a palladium-based compound, has shown inhibitory efficacy on STAT3 signaling in preclinical cancer models by elevating the expression of SHP2 and inhibiting cell proliferation, migration, invasion, and tumor metastasis. This study provides evidence for the potential consideration of Tris DBA in clinical trials for cancer treatment.

CANCERS (2021)

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Article Oncology

LncRNA LGALS8-AS1 Promotes Breast Cancer Metastasis Through miR-125b-5p/SOX12 Feedback Regulatory Network

Duanyang Zhai et al.

Summary: This study identified that the lncRNA LGALS8-AS1 is highly expressed in breast cancer and promotes the metastasis of breast cancer cells. LGALS8-AS1 upregulates SOX12 by sponging miR-125b-5p, thus activating the PI3K/AKT signaling pathway to facilitate breast cancer metastasis. The reciprocal regulatory loop of LGALS8-AS1/miR-125b-5p/SOX12 may serve as a potential therapeutic target for breast cancer treatment.

FRONTIERS IN ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Reiterating the Emergence of Noncoding RNAs as Regulators of the Critical Hallmarks of Gall Bladder Cancer

Varsha Rana et al.

Summary: Gall bladder cancer (GBC) is a rare and aggressive malignancy with poor prognosis and limited treatment options. Research shows that the atypical expression of various ncRNAs is associated with the aggressive characteristics of GBC and may serve as novel diagnostic and prognostic markers for the disease.

BIOMOLECULES (2021)

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Article Medicine, Research & Experimental

LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer

Ri Chen et al.

Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.

LABORATORY INVESTIGATION (2021)

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Article Cell Biology

Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis

Mei-Ling Xu et al.

Aging-US (2021)

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Review Biochemistry & Molecular Biology

Paradoxical functions of long noncoding RNAs in modulating STAT3 signaling pathway in hepatocellular carcinoma

Chakrabhavi Dhananjaya Mohan et al.

Summary: Hepatocellular carcinoma (HCC) is a deadly cancer with a high mortality rate, and STAT3 plays a crucial role in its development by regulating various genes and cellular functions. Long noncoding RNAs (lncRNAs) influence STAT3 signaling through diverse molecular mechanisms, impacting the pathogenesis and progression of HCC.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Medicine, Research & Experimental

New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities

Milad Ashrafizadeh et al.

Summary: EMT mechanism is responsible for cancer cell metastasis and migration, as well as drug resistance. Taxene chemotherapeutic agents PTX and DTX induce cancer cell cycle arrest by preventing microtubule depolymerization, while upstream mediators of EMT such as ZEB1/2 and TGF-ll affect cancer cells' response to these drugs.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Biochemistry & Molecular Biology

LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition

Lee Kyung Kim et al.

Summary: The study indicates that lncRNA SRA plays an important regulatory role in ovarian cancer, with high expression being closely associated with recurrence-free survival in patients.

BIOSCIENCE REPORTS (2021)

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Article Oncology

Regulation of Nuclear Factor-KappaB (NF-kB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

Sepideh Mirzaei et al.

Summary: The NF-xB signaling pathway is a potential therapeutic target in cancer therapy, with its dysregulation impacting cancer cell proliferation, metastasis, and resistance to radiotherapy and chemotherapy. Non-coding RNAs, such as miRNAs, lncRNAs, and circRNAs, play a crucial role in modulating NF-xB signaling and may affect cancer progression by regulating miRNAs targeting NF-xB activation.

CANCER LETTERS (2021)

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Article Cell Biology

LncRNA CYTOR drives L-OHP resistance and facilitates the epithelial-mesenchymal transition of colon carcinoma cells via modulating miR-378a-5p/SERPINE1

Jialin Yang et al.

Summary: The study identified that lncRNA CYTOR enhances chemoresistance and induces EMT in colon carcinoma by inhibiting miR-378a-5p expression and its downstream target SERPINE1. The regulatory pathway involving lncRNA CYTOR/miR-378a-5p/SERPINE1 could serve as potential therapeutic targets and prognostic biomarkers for colon carcinoma treatment.

CELL CYCLE (2021)

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Article Oncology

microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/β-catenin signaling pathway

K. Liang et al.

Summary: In this study, miR-377-3p was found to be downregulated in osteosarcoma tissues and cells, and its restoration could suppress cell growth and migration by regulating EMT and Wnt/β-catenin pathways. Additionally, CUL1 was identified as a functional target of miR-377-3p, and its elevated expression in OS tissues was associated with poor prognosis. Furthermore, miR-377-3p overexpression inhibited OS tumor growth in vivo.

CLINICAL & TRANSLATIONAL ONCOLOGY (2021)

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Article Environmental Sciences

LncRNA PSMA3-AS1 promotes cell proliferation, migration, and invasion in ovarian cancer by activating the PI3K/Akt pathway via the miR-378a-3p/GALNT3 axis

Zhihong Xu et al.

Summary: In ovarian cancer, PSMA3-AS1 promotes cell proliferation, migration, and invasion by activating the PI3K/Akt pathway through regulation of the miR-378a-3p/GALNT3 axis.

ENVIRONMENTAL TOXICOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNAs correlate with genomic stability in prostate cancer: A clinical outcome and survival analysis

Wang Jianfeng et al.

Summary: This study identified genomic instability-related lncRNAs using a computational approach, and constructed an lncRNA signature for predicting the survival outcomes of patients with prostate cancer. The signature is an independent predictor of overall survival, and may be more significant in outcome prediction compared to classic prognostic markers.

GENOMICS (2021)

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Review Biochemistry & Molecular Biology

Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence

Mahshid Deldar Abad Paskeh et al.

Summary: miRNA-489 serves as a tumor suppressor in various cancers by sensitizing cancer cells to chemotherapy, inhibiting metastasis, and disrupting oncogenic pathways. Restoring miRNA-489 expression could enhance drug sensitivity in tumors and potentially serve as a diagnostic tool for cancer detection.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Review Nanoscience & Nanotechnology

The Significance of Exosomes in Pathogenesis, Diagnosis, and Treatment of Esophageal Cancer

Zhao Jing et al.

Summary: Esophageal cancer is a common malignancy in China with high mortality, and understanding the role of exosomes in cancer progression can help improve prognosis. Exosomes are small vesicular structures that contain various components involved in cell-to-cell communication and material exchange, playing a role in cancer growth, metastasis, and angiogenesis. They also have potential as diagnostic and prognostic markers in cancer. This review discusses the significance of exosomes in esophageal cancer progression, microenvironment remodeling, therapeutic resistance, and immunosuppression, as well as their utility as diagnostic and prognostic biomarkers and therapeutic tools.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Biochemistry & Molecular Biology

Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma

Chakrabhavi Dhananjaya Mohan et al.

Summary: Crocetin inhibits STAT3 activation in HCC cells and affects the expression of multiple genes associated with cancer, thereby suppressing cell proliferation and invasive capacity.

IUBMB LIFE (2021)

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Article Oncology

Inhibiting the redox function of APE1 suppresses cervical cancer metastasis via disengagement of ZEB1 from E-cadherin in EMT

Qing Li et al.

Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

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Article Biochemistry & Molecular Biology

LncRNA CASC21 induces HGH1 to mediate colorectal cancer cell proliferation, migration, EMT and stemness

Chenxin Zhang et al.

Summary: The study demonstrated that CASC21 enhances the malignancy of CRC by promoting cell proliferation and migration, recruiting POU5F1B, and up-regulating HGH1 expression through competitive sponging of miR-485-5p.

RNA BIOLOGY (2021)

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Article Oncology

FOXO3a inhibits the EMT and metastasis of breast cancer by regulating TWIST-1 mediated miR-10b/CADM2 axis

Long Jin et al.

Summary: FOXO3a inhibits the epithelial-mesenchymal transition and metastasis of breast cancer via the TWIST-1/miR-10b/CADM2 axis, offering potential therapeutic strategies for the treatment of breast cancer.

TRANSLATIONAL ONCOLOGY (2021)

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Article Medicine, Research & Experimental

FOXP3 facilitates the invasion and metastasis of non-small cell lung cancer cells through regulating VEGF, EMT and the Notch1/Hes1 pathway

Chun Li et al.

Summary: FOXP3 promotes the migratory and invasive abilities of NSCLC cells through regulating VEGF, EMT, and the Notch1/Hes1 pathway.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Oncology

Long non-coding RNA TMCC1-AS1 predicts poor prognosis and accelerates epithelial-mesenchymal transition in liver cancer

Cheng Chen et al.

Summary: TMCC1-AS1 is significantly upregulated in liver cancer tissues and cell lines, and high expression is associated with advanced tumor stage and lymph node metastasis, as well as predict poor survival in patients. Knockdown of TMCC1-AS1 inhibits cell proliferation, migration, and invasion, while overexpression has the opposite effects in HepG2 and SNU-182 cells.

ONCOLOGY LETTERS (2021)

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Article Cell Biology

Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression

Shibin Cai et al.

Summary: A1BG-AS1 was found to be highly expressed in breast cancer tissues and cell lines, and its depletion led to suppressed cell proliferation, accelerated apoptosis, and hindered migration and invasion in breast cancer. A1BG-AS1 acts as a molecular sponge for miR-485-5p and subsequently increases FLOT1 expression in breast cancer cells, suggesting a potential novel therapeutic target for breast cancer.

HUMAN CELL (2021)

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Article Medicine, Research & Experimental

lncRNA MIR210HG promotes the progression of endometrial cancer by sponging miR-337-3p/137 via the HMGA2-TGF-f3/Wnt pathway

Jian Ma et al.

Summary: EMT promotes tumorigenesis and metastasis while increasing tumor tolerance to treatment. MIR210HG overexpression in endometrial cancer tissues is associated with poor prognosis, and its regulation of the miR-337-3p/137-HMGA2 axis suggests potential as a therapeutic target for endometrial cancer.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Review Chemistry, Multidisciplinary

Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances

Yavuz Nuri Ertas et al.

Summary: Cancer stem cells (CSCs) play a crucial role in tumor growth, metastasis, recurrence, and drug resistance. They are maintained within a niche by unique factors in the microenvironment. Using nanoparticles as carriers for anticancer drugs enables targeted delivery to CSCs, contributing to advancements in cancer therapy.

NANOMATERIALS (2021)

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Article Oncology

LncRNA SNHG3 Promotes Gastric Cancer Cells Proliferation, Migration, and Invasion by Targeting miR-326

Jun Rao et al.

Summary: The study revealed that lncRNA SNHG3 may promote the progression of GC through the miR-326/TWIST axis, serving as a potential diagnostic and prognostic biomarker for GC.

JOURNAL OF ONCOLOGY (2021)

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Article Cell Biology

LncRNA DGCR5 Isoform-1 Silencing Suppresses the Malignant Phenotype of Clear Cell Renal Cell Carcinoma via miR-211-5p/Snail Signal Axis

Guang-Xin Zhong et al.

Summary: DGCR5 isoform-1 is highly expressed in ccRCC and exerts a tumor-promoting effect by sequestering miR-211-5p and regulating Snail protein expression, thereby promoting proliferation and migration of ccRCC cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

LncRNA HCP5 Induces Gastric Cancer Cell Proliferation, Invasion, and EMT Processes Through the miR-186-5p/WNT5A Axis Under Hypoxia

Ming Gao et al.

Summary: The study confirmed that the upregulation of WNT5A expression by HCP5 competitively binding to miR-186-5p promotes the development of GC cells. In GC tissues, an increase in HCP5 and WNT5A expressions and a reduction in miR-186-5p expression were found, with a negative correlation between miR-186-5p and HCP5/WNT5A. The inhibition of HCP5 suppressed cell activity and EMT in GC cells under hypoxia, while the inhibition of miR-186-5p or the overexpression of WNT5A had opposite effects.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Cell Biology

Jolkinolide B attenuates laryngeal cancer cell growth and induces apoptosis via PTEN/PI3K/Akt signaling pathway

Lei Dong et al.

Summary: The study suggests that JB inhibits proliferation, migration, and invasion of laryngeal cancer cells while promoting apoptosis, possibly through modulation of the PI3K/Akt pathway.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2021)

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Article Oncology

Long Non-Coding RNA NRON promotes Tumor Proliferation by regulating ALKBH5 and Nanog in Gastric Cancer

Shuchang Wang et al.

Summary: lncRNA NRON is upregulated in gastric cancer, associated with malignant features and poor prognosis, promoting proliferation and tumorigenesis of GC cells by binding to ALKHBS and mediating Nanog mRNA decay. Its overexpression suggests NRON could be a potential therapeutic target for GC patients.

JOURNAL OF CANCER (2021)

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Article Oncology

miR-30a/SOX4 Double Negative Feedback Loop is modulated by Disulfiram and regulates EMT and Stem Cell-like properties in Breast Cancer

Zijian Liu et al.

Summary: miR-30a inhibits EMT and CSC phenotypes in breast cancer cells by targeting SOX4 and forming a double-negative feedback loop. Knockdown of SOX4 suppresses EMT and CSC phenotypes through the TGF-beta/SMAD pathway, consistent with the effects of miR-30a overexpression. High expression of miR-30a is associated with a good prognosis in breast cancer patients.

JOURNAL OF CANCER (2021)

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Article Biotechnology & Applied Microbiology

Long non-coding RNA PTAR inhibits apoptosis but promotes proliferation, invasion and migration of cervical cancer cells by binding miR-101

Xuehe Wang et al.

Summary: The study demonstrated that an aberrant upregulation of PTAR in cervical cancer tissues and cell lines promotes proliferation, migration, and invasion of HeLa cells, while inhibiting apoptosis and downregulating miR-101 expression through direct binding. These findings suggest that PTAR plays a crucial role and may serve as a promising target for cervical cancer diagnosis and therapy.

BIOENGINEERED (2021)

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Article Biochemistry & Molecular Biology

MEF2A-mediated lncRNA HCP5 Inhibits Gastric Cancer Progression via MiR-106b-5p/p21 Axis

Weiwei Chen et al.

Summary: This study found significantly downregulated HCP5 expression in gastric cancer tissues, and depletion of HCP5 facilitated cell proliferation, migration, and invasion. Moreover, MEF2A-mediated HCP5 exerted an anti-tumor effect in gastric cancer development through the miR-106b-5p/p21 axis.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Oncology

Design and Functional Validation of a Mutant Variant o f the LncRNA HOTAIR to Counteract Snail Function in Epithelial-to-Mesenchymal Transition

Cecilia Battistelli et al.

Summary: The study introduced a mutant form of HOTAIR called HOTAIR-sbid, which can disrupt the function of HOTAIR in regulating specific epithelial target genes, affecting the EMT process and reducing the invasiveness and motility of tumor cells.

CANCER RESEARCH (2021)

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Article Oncology

lncRNA CASC9 sponges miR-758-3p to promote proliferation and EMT in bladder cancer by upregulating TGF-β2

Zeng Zhang et al.

Summary: The long noncoding RNA CASC9 is an oncogenic gene in several types of cancer, including bladder cancer, where it regulates epithelial-mesenchymal transition (EMT). Upregulation of CASC9 is associated with increased invasion ability and poor prognosis in bladder cancer. CASC9 functions as a competing endogenous RNA for miR-758-3p, regulating the expression of TGF-beta 2 and promoting proliferation and EMT in bladder cancer.

ONCOLOGY REPORTS (2021)

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Article Obstetrics & Gynecology

Long noncoding RNA ZEB1-AS1 affects paclitaxel and cisplatin resistance by regulating MMP19 in epithelial ovarian cancer cells

Chencheng Dai et al.

Summary: The study revealed that ZEB1-AS1 plays a pivotal role in cancer chemoresistance by regulating MMP19, providing a potential target for overcoming drug resistance in ovarian cancer cells.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2021)

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Article Oncology

Curcumin attenuates lncRNA H19-induced epithelial-mesenchymal transition in tamoxifen-resistant breast cancer cells

Jiaqin Cai et al.

Summary: H19 plays a role in promoting EMT, invasion, and migration in MCF-7/TAMR cells, and curcumin can inhibit H19-mediated effects and decrease the expression of H19 in cells. This suggests that curcumin may serve as a promising therapeutic drug for TAMR breast cancer patients.

MOLECULAR MEDICINE REPORTS (2021)

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Article Biochemistry & Molecular Biology

LncRNA GHET1 promotes cervical cancer progression through regulating AKT/mTOR and Wnt/β-catenin signaling pathways

Zhihui Liu et al.

BIOSCIENCE REPORTS (2020)

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Article Oncology

LncRNA ID2-AS1 suppresses tumor metastasis by activating the HDAC8/ID2 pathway in hepatocellular carcinoma

Yuqiang Zhou et al.

CANCER LETTERS (2020)

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Article Cell Biology

SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer

Yangmei Zhang et al.

CELL CYCLE (2020)

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Article Cell Biology

Long noncoding RNA SNHG12 modulated by human papillomavirus 16 E6/E7 promotes cervical cancer progression via ERK/Slug pathway

Shu-Yu Lai et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Article Oncology

SMAD3/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-beta signaling promotes prostate cancer bone metastasis

Chuandong Lang et al.

MOLECULAR ONCOLOGY (2020)

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Article Biochemistry & Molecular Biology

LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNPA1 expression

Zhili Wen et al.

RNA BIOLOGY (2020)

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Article Biotechnology & Applied Microbiology

LncRNA PCAT6 Accelerates the Progression and Chemoresistance of Cervical Cancer Through Up-Regulating ZEB1 by Sponging miR-543

Zhongping Ma et al.

ONCOTARGETS AND THERAPY (2020)

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Article Oncology

LncRNA HRCEG, regulated by HDAC1, inhibits cells proliferation and epithelial-mesenchymal-transition in gastric cancer

Shuheng Wu et al.

CANCER GENETICS (2020)

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Review Oncology

Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis

Klaudia Skrzypek et al.

CANCERS (2020)

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Article Gastroenterology & Hepatology

LncRNA SNHG1 promotes EMT process in gastric cancer cells through regulation of the miR-15b/DCLK1/Notch1 axis

Zhi-Qi Liu et al.

BMC GASTROENTEROLOGY (2020)

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Article Oncology

LncRNA NNT-AS1 contributes to the cisplatin resistance of cervical cancer through NNT-AS1/miR-186/HMGB1 axis

Yanjie Liu et al.

CANCER CELL INTERNATIONAL (2020)

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Article Biotechnology & Applied Microbiology

LncRNA PTENP1 inhibits cervical cancer progression by suppressing miR-106b

Yingrui Fan et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Tumor-Suppressive Function of lncRNA-MEG3 in Glioma Cells by Regulating miR-6088/SMARCB1 Axis

Xin Gong et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

Long Noncoding RNA KIF9-AS1 Regulates Transforming Growth Factor-β and Autophagy Signaling to Enhance Renal Cell Carcinoma Chemoresistance via microRNA-497-5p

Yichen Jin et al.

DNA AND CELL BIOLOGY (2020)

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Article Medicine, Research & Experimental

LncRNA MAGI2-AS3 Is Regulated by BRD4 and Promotes Gastric Cancer Progression via Maintaining ZEB1 Overexpression by Sponging miR-141/200a

Dandan Li et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Article Oncology

lncRNA ZFAS1 Is Involved in the Proliferation, Invasion and Metastasis of Prostate Cancer Cells Through Competitively Binding to miR-135a-5p

Jiaqiang Pan et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Biotechnology & Applied Microbiology

Long Non-Coding RNA SPRY4-IT1 Reverses Cisplatin Resistance by Downregulating MPZL-1 via Suppressing EMT in NSCLC

Yunyao Ye et al.

ONCOTARGETS AND THERAPY (2020)

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Article Biotechnology & Applied Microbiology

lncRNA MALATI Promotes EMT Process and Cisplatin Resistance of Oral Squamous Cell Carcinoma via PI3K/AKT/m-TOR Signal Pathway

Ran Wang et al.

ONCOTARGETS AND THERAPY (2020)

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Article Cell Biology

LncRNA SNHG17 aggravated prostate cancer progression through regulating its homolog SNORA71B via a positive feedback loop

Gaoliang Wu et al.

CELL DEATH & DISEASE (2020)

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Article Oncology

LncRNA SNHG3 sponges miR-577 to up-regulate SMURF1 expression in prostate cancer

Teng Li et al.

CANCER MEDICINE (2020)

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Article Medicine, General & Internal

LncRNA ZEB1-AS1 regulates colorectal cancer cells by miR-205/YAP1 axis

Zhong Jin et al.

OPEN MEDICINE (2020)

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Article Oncology

Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1

Xinxing Lu et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Biochemistry & Molecular Biology

LncRNA ZEB1-AS1 promotes pancreatic cancer progression by regulating miR-505-3p/TRIB2 axis

Guohua Wei et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Vitexin abrogates invasion and survival of hepatocellular carcinoma cells through targeting STAT3 signaling pathway

Jong Hyun Lee et al.

BIOCHIMIE (2020)

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Review Medicine, Research & Experimental

Long non-coding RNAs: Key regulators in oxaliplatin resistance of colorectal cancer

Fang-fang Qi et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

The transcription factor USF1 promotes glioma cell invasion and migration by activating lncRNA HAS2-AS1

Juntong Wang et al.

BIOSCIENCE REPORTS (2020)

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Article Oncology

Knockdown of lncRNA PVT1 inhibits prostate cancer progression in vitro and in vivo by the suppression of KIF23 through stimulating miR-15a-5p

Huijuan Wu et al.

CANCER CELL INTERNATIONAL (2020)

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Review Biochemistry & Molecular Biology

Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance

Milad Ashrafizadeh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Oncology

Exosomal Transfer of lncRNA H19 Promotes Erlotinib Resistance in Non-Small Cell Lung Cancer via miR-615-3p/ATG7 Axis

Rongtao Pan et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Oncology

LncRNA CDKN2B-AS1 Promotes Cell Viability, Migration, and Invasion of Hepatocellular Carcinoma via Sponging miR-424-5p

Xinying Shen et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Multidisciplinary Sciences

Brusatol suppresses STAT3-driven metastasis by downregulating epithelial-mesenchymal transition in hepatocellular carcinoma

Jong Hyun Lee et al.

JOURNAL OF ADVANCED RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer

Milad Ashrafizadeh et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

Xiaoxiang Chen et al.

MOLECULAR CANCER (2020)

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Review Oncology

Gastric cancer: a comprehensive review of current and future treatment strategies

Rachel E. Sexton et al.

CANCER AND METASTASIS REVIEWS (2020)

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Article Oncology

LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX

Dafeng Xu et al.

CANCER BIOLOGY & THERAPY (2020)

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Article Oncology

LncRNA SNHG6 enhances the radioresistance and promotes the growth of cervical cancer cells by sponging miR-485-3p

Jin Liu et al.

CANCER CELL INTERNATIONAL (2020)

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Article Oncology

LncRNA PVT1 induces aggressive vasculogenic mimicry formation through activating the STAT3/Slug axis and epithelial-to-mesenchymal transition in gastric cancer

Jing Zhao et al.

CELLULAR ONCOLOGY (2020)

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Article Urology & Nephrology

LncRNA PLAC2 upregulates miR-663 to downregulate TGF-β1 and suppress bladder cancer cell migration and invasion

Zhenxing Zhang et al.

BMC UROLOGY (2020)

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Article Cell Biology

LncRNA HOXA-AS3 promotes the malignancy of glioblastoma through regulating miR-455-5p/USP3 axis

Wanghao Chen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Oncology

lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR-106a-5p-mediated P38 MAPK signaling

Ting Tang et al.

MOLECULAR MEDICINE REPORTS (2020)

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Article Biotechnology & Applied Microbiology

被撤回的出版物: LncRNA LINC01116 Contributes to Cisplatin Resistance in Lung Adenocarcinoma (Retracted article. See vol. 16, pg. 615, 2023)

Junbin Wang et al.

ONCOTARGETS AND THERAPY (2020)

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Article Cell Biology

LncRNA ADAMTS9-AS1, as prognostic marker, promotes cell proliferation and EMT in colorectal cancer

Wanjing Chen et al.

HUMAN CELL (2020)

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Article Multidisciplinary Sciences

Novel role of lncRNA CHRF in cisplatin resistance of ovarian cancer is mediated by miR-10b induced EMT and STAT3 signaling

Wen-Xi Tan et al.

SCIENTIFIC REPORTS (2020)

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Article Oncology

LncRNA-SNHG7 Enhances Chemotherapy Resistance and Cell Viability of Breast Cancer Cells by Regulating miR-186

Hui Zhang et al.

CANCER MANAGEMENT AND RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Corilagin Represses Epithelial to Mesenchymal Transition Process Through Modulating Wnt/β-Catenin Signaling Cascade

Sun Tae Hwang et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

lncRNA CTBP1-AS2 promotes proliferation and migration of glioma by modulating miR-370-3p-Wnt7a-mediated epithelial-mesenchymal transition

Yongfeng Li et al.

BIOCHEMISTRY AND CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential

Gouri Pandya et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Review Biochemistry & Molecular Biology

Pharmacological significance of the non-canonical NF-κB pathway in tumorigenesis

Dhakshayini Morgan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Letter Medicine, General & Internal

LncRNA FAL1 promotes proliferation, invasion and EMT of gastric cancer through the PTEN/AKT pathway

Yangyang Ouyang et al.

MINERVA MEDICA (2020)

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Article Nanoscience & Nanotechnology

Exosomal lncRNA ROR1-AS1 Derived from Tumor Cells Promotes Glioma Progression via Regulating miR-4686

Yang Chai et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Biology

LncRNA OIP5-AS1 upregulates snail expression by sponging miR-34a to promote ovarian carcinoma cell invasion and migration

Xingzhi Jiang et al.

BIOLOGICAL RESEARCH (2020)

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Article Cell & Tissue Engineering

LncRNA DLX6-AS1 Contributes to Epithelial-Mesenchymal Transition and Cisplatin Resistance in Triple-negative Breast Cancer via Modulating Mir-199b-5p/Paxillin Axis

Chuang Du et al.

CELL TRANSPLANTATION (2020)

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Article Biochemistry & Molecular Biology

Breast cancer-derived exosomes transmit lncRNA SNHG16 to induce CD73+γδ1 Treg cells

Chao Ni et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Medicine, Research & Experimental

Long non-coding RNAs in gastric cancer: New emerging biological functions and therapeutic implications

Huidan Tan et al.

THERANOSTICS (2020)

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Article Cell Biology

LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR-128/CD151 pathway in hepatocellular carcinoma

Peng-Fei Zhang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Oncology

Hypoxia-induced LncRNA PCGEM1 promotes invasion and metastasis of gastric cancer through regulating SNAI1

J. Zhang et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2019)

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Article Biochemistry & Molecular Biology

The expanding roles of long non-coding RNAs in the regulation of cancer stem cells

Zhaowu Ma et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

LncRNA SNHG16 aggravates tumorigenesis and development of hepatocellular carcinoma by sponging miR-4500 and targeting STAT3

Qing Lin et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

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Article Biochemistry & Molecular Biology

Knockdown of lncRNA MNX1-AS1 suppresses cell proliferation, migration, and invasion in prostate cancer

Zongwu Li et al.

FEBS OPEN BIO (2019)

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Article Physiology

LncRNA MALAT1, an lncRNA acting via the miR-204/ZEB1 pathway, mediates the EMT induced by organic extract of PM2.5 in lung bronchial epithelial cells

Fei Luo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis

Yingru Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Cell Biology

DANCR promotes HCC progression and regulates EMT by sponging miR-27a-3p via ROCK1/LIMK1/COFILIN1 pathway

Dan Guo et al.

CELL PROLIFERATION (2019)

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Article Oncology

Long non-coding RNA TPTEP1 inhibits hepatocellular carcinoma progression by suppressing STAT3 phosphorylation

Hongda Ding et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Medicine, Research & Experimental

lncRNA UCA1 Mediates Resistance to Cisplatin by Regulating the miR-143/FOSL2-Signaling Pathway in Ovarian Cancer

Zewu Li et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Article Biochemistry & Molecular Biology

KRT18 is correlated with the malignant status and acts as an oncogene in colorectal cancer

Jingfeng Zhang et al.

BIOSCIENCE REPORTS (2019)

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Review Biochemistry & Molecular Biology

Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis

Ke Jin et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Oncology

LncRNA CASC9 interacts with CPSF3 to regulate TGF- signaling in colorectal cancer

Kaili Luo et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

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Article Plant Sciences

Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells

Sun Tae Hwang et al.

PHYTOMEDICINE (2019)

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Article Medicine, Research & Experimental

The long non-coding RNA HOTAIRM1 suppresses cell progression via sponging endogenous miR-17-5p/B-cell translocation gene 3 (BTG3) axis in 5-fluorouracil resistant colorectal cancer cells

Tiejun Ren et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Cell Biology

Downregulated lncRNA UCA1 acts as ceRNA to adsorb microRNA-498 to repress proliferation, invasion and epithelial mesenchymal transition of esophageal cancer cells by decreasing ZEB2 expression

Peng Wang et al.

CELL CYCLE (2019)

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Article Biochemistry & Molecular Biology

LncRNA XIST promotes pancreatic cancer migration, invasion and EMT by sponging miR-429 to modulate ZEB1 expression

Jie Shen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Long non-coding RNA NONHSAT101069 promotes epirubicin resistance, migration, and invasion of breast cancer cells through NONHSAT101069/miR-129-5p/Twist1 axis

Na Yao et al.

ONCOGENE (2019)

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Article Biotechnology & Applied Microbiology

Positive feedback loop of lncRNA HOXC-AS2/miR-876-5p/ZEB1 to regulate EMT in glioma

Nan Dong et al.

ONCOTARGETS AND THERAPY (2019)

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Article Biotechnology & Applied Microbiology

LncRNA RHPN1-AS1 Targeting miR-625/REG3A Promotes Cell Proliferation And Invasion Of Glioma Cells

Peng Cui et al.

ONCOTARGETS AND THERAPY (2019)

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Article Cell Biology

Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma

Chenlong Li et al.

CELL DEATH & DISEASE (2019)

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Article Oncology

miR-124-3p availability is antagonized by LncRNA-MALAT1 for Slug-induced tumor metastasis in hepatocellular carcinoma

Rong-Jun Cui et al.

CANCER MEDICINE (2019)

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Review Cell Biology

Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition

Jun-Ting Cheng et al.

CELLS (2019)

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Article Biochemistry & Molecular Biology

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma

Jong Hyun Lee et al.

BIOMOLECULES (2019)

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Article Medicine, Research & Experimental

LncRNA NONHSAT113026 represses renal cell carcinoma tumorigenesis through interacting with NF-κB/p50 and SLUG

Yan Pu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Oncology

The lncRNA DLX6-AS1 promoted cell proliferation, invasion, migration and epithelial-to-mesenchymal transition in bladder cancer via modulating Wnt/β-catenin signaling pathway

Jinan Guo et al.

CANCER CELL INTERNATIONAL (2019)

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LncRNA-CTS promotes metastasis and epithelial-to-mesenchymal transition through regulating miR-505/ZEB2 axis in cervical cancer

Shujun Feng et al.

CANCER LETTERS (2019)

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MiR-195 inhibits migration, invasion and epithelial-mesenchymal transition (EMT) of endometrial carcinoma cells by targeting SOX4

Xiaomeng Zhao et al.

JOURNAL OF BIOSCIENCES (2019)

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LncRNA ZEB1-AS1 down-regulation suppresses the proliferation and invasion by inhibiting ZEB1 expression in oesophageal squamous cell carcinoma

Yan Zhao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Xinming Jing et al.

MOLECULAR CANCER (2019)

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LncRNA HOXA-AS3 confers cisplatin resistance by interacting with HOXA3 in non-small-cell lung carcinoma cells

Shuang Lin et al.

ONCOGENESIS (2019)

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Role of tumor-derived exosomes in cancer metastasis

Ian Wee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2019)

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Histone Demethylase KDM4B Promotes DNA Damage by Activating Long Interspersed Nuclear Element-1

Ying Xiang et al.

CANCER RESEARCH (2019)

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The contrary functions of lncRNA HOTAIR/miR-17-5p/PTEN axis and Shenqifuzheng injection on chemosensitivity of gastric cancer cells

Jianguang Jia et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

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LncRNA DANCR promotes cervical cancer progression by upregulating ROCK1 via sponging miR-335-5p

Huiling Liang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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lncRNA DRHC inhibits proliferation and invasion in hepatocellular carcinoma via c-Myb-regulated MEK/ERK signaling

Runzhou Zhuang et al.

MOLECULAR CARCINOGENESIS (2019)

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New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer

Anushka Dongre et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Farnesol abrogates epithelial to mesenchymal transition process through regulating Akt/mTOR pathway

Jong Hyun Lee et al.

PHARMACOLOGICAL RESEARCH (2019)

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LncRNA RP11-422N16.3 Inhibits Cell Proliferation and EMT, and Induces Apoptosis in Hepatocellular Carcinoma Cells by Sponging miR-23b-3p

Yunpeng Sun et al.

ONCOTARGETS AND THERAPY (2019)

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Article Biotechnology & Applied Microbiology

Exosome-Mediated Transfer of lncRNA HOTTIP Promotes Cisplatin Resistance in Gastric Cancer Cells by Regulating HMGAI/miR-218 Axis

Jingyu Wang et al.

ONCOTARGETS AND THERAPY (2019)

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Article Biochemistry & Molecular Biology

The IκB Kinase Inhibitor ACHP Targets the STAT3 Signaling Pathway in Human Non-Small Cell Lung Carcinoma Cells

Jong Hyun Lee et al.

BIOMOLECULES (2019)

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Targeting Heparanase in Cancer: Inhibition by Synthetic, Chemically Modified, and Natural Compounds

Chakrabhavi Dhananjaya Mohan et al.

ISCIENCE (2019)

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LncRNA SNHG6 promotes proliferation, invasion and migration in colorectal cancer cells by activating TGF-β/Smad signaling pathway via targeting UPF1 and inducing EMT via regulation of ZEB1

Xinke Wang et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

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Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

Shruti Mishra et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Long non-coding RNA ROR promotes radioresistance in hepatocelluar carcinoma cells by acting as a ceRNA for microRNA-145 to regulate RAD18 expression

Ying Chen et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2018)

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Article Biochemistry & Molecular Biology

LncRNA TP73-AS1 predicts the prognosis of bladder cancer patients and functions as a suppressor for bladder cancer by EMT pathway

Zhiyong Tuo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

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Article Biochemistry & Molecular Biology

LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1α

Wei Zhang et al.

BIOCHIMIE (2018)

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Long non-coding RNA SNHG15 interacts with and stabilizes transcription factor Slug and promotes colon cancer progression

Hao Jiang et al.

CANCER LETTERS (2018)

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Novel tumor necrosis factor-alpha induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression

Ganesan Padmavathi et al.

CANCER LETTERS (2018)

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LncRNA LINC00152 promoted glioblastoma progression through targeting the miR-107 expression

Xinzhi Liu et al.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2018)

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LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells

Yanmei Zou et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2018)

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Involvement of partial EMT in cancer progression

Masao Saitoh

JOURNAL OF BIOCHEMISTRY (2018)

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Chemotherapy-Induced Long Non-coding RNA 1 Promotes Metastasis and Chemo-Resistance of TSCC via the Wnt/β-Catenin Signaling Pathway

Zhaoyu Lin et al.

MOLECULAR THERAPY (2018)

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Bergamottin Suppresses Metastasis of Lung Cancer Cells through Abrogation of Diverse Oncogenic Signaling Cascades and Epithelial-to-Mesenchymal Transition

Jeong-Hyeon Ko et al.

MOLECULES (2018)

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Article Biochemistry & Molecular Biology

Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription

Shi-jiang Deng et al.

ONCOGENE (2018)

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Long noncoding RNA H19 promotes transforming growth factor-β-induced epithelial-mesenchymal transition by acting as a competing endogenous RNA of miR-370-3p in ovarian cancer cells

Jing Li et al.

ONCOTARGETS AND THERAPY (2018)

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Targeted Agents in Cervical Cancer: Beyond Bevacizumab

Gloria Marquina et al.

CURRENT ONCOLOGY REPORTS (2018)

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Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis

Junqing Guo et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

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Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Freddie Bray et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2018)

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Enhanced expression of lncRNA TP73-AS1 predicts unfavorable prognosis for gastric cancer and promotes cell migration and invasion by induction of EMT

Wei Zhang et al.

GENE (2018)

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Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Abhishek Manoj Ranaware et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression

Haihai Liang et al.

MOLECULAR CANCER (2018)

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LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1

Chao Liang et al.

PATHOLOGY RESEARCH AND PRACTICE (2018)

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Exosome-related tumor microenvironment

Cheng Hu et al.

JOURNAL OF CANCER (2018)

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Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

Muthu K. Shanmugam et al.

FRONTIERS IN PHARMACOLOGY (2018)

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lncRNA GAS5 Reverses EMT and Tumor Stem Cell-Mediated Gemcitabine Resistance and Metastasis by Targeting miR-221/SOCS3 in Pancreatic Cancer

Bingyan Liu et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2018)

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Dysregulation of Nrf2 in Hepatocellular Carcinoma: Role in Cancer Progression and Chemoresistance

Azhwar Raghunath et al.

CANCERS (2018)

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ZEB Proteins in Leukemia: Friends, Foes, or Friendly Foes?

Bieke Soen et al.

HEMASPHERE (2018)

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Long Non-Coding RNA XLOC_006753 Promotes the Development of Multidrug Resistance in Gastric Cancer Cells Through the PI3K/AKT/mTOR Signaling Pathway

Lisi Zeng et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)

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Exosomal Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes Angiogenesis and Predicts Poor Prognosis in Epithelial Ovarian Cancer

Jun-Jun Qiu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

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Sorafenib resistance in hepatocarcinoma: role of hypoxia-inducible factors

Carolina Mendez-Blanco et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

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The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition

C. Battistelli et al.

ONCOGENE (2017)

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Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma

Supritha G. Swamy et al.

TARGETED ONCOLOGY (2017)

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lncRNA CCAT1 Promotes Glioma Tumorigenesis by Sponging miR-181b

Bingzhou Cui et al.

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LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells

Ching-Ju Shen et al.

JOURNAL OF DRUG TARGETING (2017)

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Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

Wanpei Cai et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Down-regulation of LncRNA TUG1 enhances radiosensitivity in bladder cancer via suppressing HMGB1 expression

Huijuan Jiang et al.

RADIATION ONCOLOGY (2017)

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Sorafenib: A Review in Hepatocellular Carcinoma

Gillian M. Keating

TARGETED ONCOLOGY (2017)

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Downregulation of long noncoding RNA TUG1 inhibits proliferation and induces apoptosis through the TUG1/miR-142/ZEB2 axis in bladder cancer cells

Qian Liu et al.

ONCOTARGETS AND THERAPY (2017)

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LncRNA ANCR down-regulation promotes TGF-β-induced EMT and metastasis in breast cancer

Zhongwei Li et al.

Oncotarget (2017)

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LncRNA HSP90AA1-IT1 promotes gliomas by targeting miR-8855p-CDK2 pathway

Taihong Gao et al.

ONCOTARGET (2017)

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Wanted DEAD/H or Alive: Helicases Winding Up in Cancers

Wanpei Cai et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

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Cancer Statistics, 2017

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2017)

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lncRNA H19 regulates epithelial-mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA

Mengxin Lv et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

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Long non-coding RNA HOTTIP promotes hypoxia-induced epithelial-mesenchymal transition of malignant glioma by regulating the miR-101/ZEB1 axis

Shanyi Zhang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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miR-218 suppresses gastric cancer cell cycle progression through the CDK6/Cyclin D1/E2F1 axis in a feedback loop

Min Deng et al.

CANCER LETTERS (2017)

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Cancer Statistics, 2016

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2016)

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Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA

Le Qu et al.

CANCER CELL (2016)

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High expression of long non-coding RNA lncRNA-ATB is correlated with metastases and promotes cell migration and invasion in renal cell carcinoma

Jing Xiong et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2016)

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Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis

Xue Wang et al.

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Exosomes in tumor microenvironment: novel transporters and biomarkers

Zhen Wang et al.

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Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma

Xiaoyun Dai et al.

MOLECULAR CANCER THERAPEUTICS (2016)

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Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells

Seung Ho Baek et al.

PHYTOMEDICINE (2016)

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LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression

Zhen-zhen Chen et al.

NATURE COMMUNICATIONS (2016)

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Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer

Hui Pan et al.

ONCOTARGET (2016)

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Surgical Treatment of Early-Stage Cervical Cancer

Sara Y. Brucker et al.

ONCOLOGY RESEARCH AND TREATMENT (2016)

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Novel Synthetic Oxazines Target NF-κB in Colon Cancer In Vitro and Inflammatory Bowel Disease In Vivo

Anilkumar C. Nirvanappa et al.

PLOS ONE (2016)

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Naringenin prevents TGF-β1 secretion from breast cancer and suppresses pulmonary metastasis by inhibiting PKC activation

Fayun Zhang et al.

BREAST CANCER RESEARCH (2016)

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Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3

Xiaoyun Dai et al.

MOLECULAR ONCOLOGY (2015)

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The landscape of long noncoding RNAs in the human transcriptome

Matthew K. Iyer et al.

NATURE GENETICS (2015)

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Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer

Ningning Cheng et al.

ONCOTARGET (2015)

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LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer

Sheng-Jia Shi et al.

ONCOTARGET (2015)

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TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT

Junlong Zhuang et al.

SCIENTIFIC REPORTS (2015)

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TGFβ Signaling in Tumor Initiation, Epithelial-to-Mesenchymal Transition, and Metastasis

Panagiotis Papageorgis

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Advanced Magnetic Resonance Imaging of the Physical Processes in Human Glioblastoma

Jayashree Kalpathy-Cranner et al.

CANCER RESEARCH (2014)

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TGF-β-Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12

Yu Fan et al.

CLINICAL CANCER RESEARCH (2014)

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Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

Kanjoormana A. Manu et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2014)

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Cancer statistics, 2013

Rebecca Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2013)

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Changes in treatment patterns and their influence on long-term survival in patients with stages I-III gastric cancer in The Netherlands

A. E. Dassen et al.

INTERNATIONAL JOURNAL OF CANCER (2013)

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Exosomes in tumor microenvironment influence cancer progression and metastasis

Christoph Kahlert et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2013)

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A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tails

Jeremy E. Wilusz et al.

GENES & DEVELOPMENT (2012)

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Long noncoding RNAs are rarely translated in two human cell lines

Balazs Banfai et al.

GENOME RESEARCH (2012)

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The ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

M. Angela Nieto

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

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Colon Cancer: A Civilization Disorder

Alastair J. M. Watson et al.

DIGESTIVE DISEASES (2011)

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Targeting hypoxia in cancer therapy

William R. Wilson et al.

NATURE REVIEWS CANCER (2011)

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ZEB proteins link cell motility with cell cycle control and cell survival in cancer

Gareth Browne et al.

CELL CYCLE (2010)

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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

Jacques Ferlay et al.

INTERNATIONAL JOURNAL OF CANCER (2010)

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EMT, the cytoskeleton, and cancer cell invasion

Mahmut Yilmaz et al.

CANCER AND METASTASIS REVIEWS (2009)

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TGF-β-induced epithelial to mesenchymal transition

Jian Xu et al.

CELL RESEARCH (2009)

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Gastric cancer

Vincenzo Catalano et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2009)

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Mitchell Guttman et al.

NATURE (2009)

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Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

Stephane Ansieau et al.

CANCER CELL (2008)

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Epidemiology and molecular pathology of glioma

Judith A. Schwartzbaum et al.

NATURE CLINICAL PRACTICE NEUROLOGY (2006)

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Metastasis: a question of life or death

P Mehlen et al.

NATURE REVIEWS CANCER (2006)

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The transcription factor Snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

A Cano et al.

NATURE CELL BIOLOGY (2000)

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The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

E Batlle et al.

NATURE CELL BIOLOGY (2000)

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