Journal
PHARMACOLOGICAL RESEARCH
Volume 186, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2022.106535
Keywords
Exosomes; Metastasis; Non-coding RNA; Brain tumors; Gastrointestinal tumors; Gynecological and urological tumors
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Funding
- Council of Scientific and Industrial Research and the Indian Science Congress Association (ISCA)
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Epithelial-to-mesenchymal transition (EMT) is an important event associated with embryogenesis, tumor progression, metastasis, and therapeutic resistance. This review comprehensively discusses the role and mechanism of action of long non-coding RNAs (lncRNAs) in regulating the EMT process in various cancers, as well as their involvement in the regulation of transcription factors and therapeutic response. The review also emphasizes the role of exosomal lncRNAs in the regulation of EMT, metastasis, and therapeutic response in cancers.
Epithelial-to-mesenchymal transition (EMT) is a process that involves the transformation of polarized epithelial cells to attain a mesenchymal phenotype that presents an elevated migratory potential, invasiveness, and antiapoptotic properties. Many studies have demonstrated that EMT is a prominent event that is associated with embryogenesis, tumor progression, metastasis, and therapeutic resistance. The EMT process is driven by key transcription factors (such as Snail, Twist, ZEB, and TGF-beta) and several long non-coding RNAs (lncRNAs) in many non-pathological as well as pathological conditions. In the present report, we have comprehensively discussed the oncogenic and tumor suppressor role of lncRNAs and their mechanism of action in the regulation of the EMT process in various cancers such as brain tumors, gastrointestinal tumors, and gynecological and urological tumors. We have also elaborated on the role of lncRNAs in the regulation of EMT-related transcription factors (such as Snail, Twist, ZEB, and TGF-beta) and therapeutic response (chemoresistance and radioresistance). Lastly, we have emphasized the role of exosomal lncRNAs in the regulation of EMT, metastasis, and therapeutic response in the aforementioned cancers. Taken together, this review provides a detailed insight into the understanding of role of lncRNAs/exosomal lncRNAs in EMT, metastasis, and therapeutic response in human cancers.
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