4.7 Article

Targeting cancer stem cells in the tumor microenvironment: An emerging role of PARP inhibitors

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

PARP inhibitor BMN-673 induced apoptosis by trapping PARP-1 and inhibiting base excision repair via modulation of pol-β in chromatin of breast cancer cells

Chinmayee Sethy et al.

Summary: PARP inhibitors have shown clinical effectiveness as anti-tumor agents, but the toxicity and off-target effects of DNA damaging agents remain a challenge. In this study, we evaluated the mechanism of PARP trapping mediated anti-cancer action of QC and BMN-673 in breast cancer cells using a fluorescence-based assay system. The combination of QC and BMN-673 induced apoptosis by triggering DNA damage, and resulted in the accumulation of PARP-1 and inhibition of PARylation in the chromatin.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Veliparib in Combination With Platinum-Based Chemotherapy for First-Line Treatment of Advanced Squamous Cell Lung Cancer: A Randomized, Multicenter Phase III Study

Suresh S. Ramalingam et al.

Summary: The study found no therapeutic benefit of adding veliparib to first-line chemotherapy in current smokers with advanced sqNSCLC. However, the LP52 signature may identify a subgroup of patients likely to derive benefit from veliparib with chemotherapy.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Cell Biology

PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of Curcumin through deregulation of NECTIN-4 in oral cancer: Role of nitric oxide (NO)

Subhajit Chatterjee et al.

Summary: This study investigates the anti-angiogenic effects of Curcumin and Veliparib in oral cancer, showing that the combination inhibits NECTIN-4 mediated angiogenesis. It highlights the potential of using Curcumin-Veliparib combination to suppress angiogenesis in cancer therapy by targeting the PI3K-AKT-eNOS pathway downstream of NECTIN-4.

CELLULAR SIGNALLING (2021)

Article Oncology

Phase II trial of veliparib and temozolomide in metastatic breast cancer patients with and without BRCA1/2 mutations

Jing Xu et al.

Summary: The study evaluated the efficacy and safety of the PARP inhibitors veliparib and temozolomide in metastatic breast cancer patients with or without germline BRCA1/2 mutations. While the primary endpoint was not met in unselected or BRCA-associated breast cancer, the combination showed clinical activity in platinum-naive BRCA-associated metastatic breast cancer with manageable toxicity at lower doses than the single-agent active dose. This regimen was further evaluated in a subsequent study.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Article Genetics & Heredity

Olaparib enhances curcumin-mediated apoptosis in oral cancer cells by inducing PARP trapping through modulation of BER and chromatin assembly

Sefinew Molla et al.

Summary: The study found that treatment with Cur + Ola increased oral cancer cell death not only through catalytic inhibition of PARP-1, but also predominantly through PARP-1 trapping and indirect inhibition of chromatin remodeling.

DNA REPAIR (2021)

Article Oncology

Clinical effectiveness of olaparib monotherapy in germline BRCA-mutated, HER2-negative metastatic breast cancer in a real-world setting: phase IIIb LUCY interim analysis

Karen A. Gelmon et al.

Summary: The study evaluated the clinical effectiveness of olaparib in patients with gBRCAm, showing a significant increase in progression-free survival and consistent safety outcomes compared with previous findings.

EUROPEAN JOURNAL OF CANCER (2021)

Review Oncology

PARP1-modulated chromatin remodeling is a new target for cancer treatment

Saptarshi Sinha et al.

Summary: Cancer progression requires tumorigenic mutations in genes encoding various proteins, with chromatin remodeling playing a crucial role in regulating the expression of these mutated genes. PARP1-mediated chromatin remodeling is important in cancer therapy and can be targeted to reverse drug resistance.

MEDICAL ONCOLOGY (2021)

Article Oncology

Safety and efficacy of veliparib plus carboplatin/paclitaxel in patients with HER2-negative metastatic or locally advanced breast cancer: subgroup analyses by germline BRCA1/2 mutations and hormone receptor status from the phase-3 BROCADE3 trial

Jean-Pierre Ayoub et al.

Summary: This study aimed to evaluate the efficacy and safety of veliparib combined with carboplatin/paclitaxel in advanced HER2-negative, germline BRCA-associated breast cancer. Results showed that the addition of veliparib to carboplatin/paclitaxel provided durable benefit in subgroups defined by HR status or by gBRCA1 versus gBRCA2 mutation, with good tolerability and minimal differences in adverse events between subgroups.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

Review Cell Biology

Tumor microenvironment complexity and therapeutic implications at a glance

Roghayyeh Baghba et al.

CELL COMMUNICATION AND SIGNALING (2020)

Review Oncology

The Multifactorial Role of PARP-1 in Tumor Microenvironment

Juan Manuel Marti et al.

CANCERS (2020)

Article Pharmacology & Pharmacy

Nanoformulated quinacrine regulates NECTIN-4 domain specific functions in cervical cancer stem cells

Subhajit Chatterjee et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Review Biotechnology & Applied Microbiology

Poly-ADP ribosylation in DNA damage response and cancer therapy

Wei-Hsien Hou et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2019)

Review Pharmacology & Pharmacy

Therapeutic considerations of PARP in stem cell biology: Relevance in cancer and beyond

M. Zeniou et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Medicine, General & Internal

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

Talia Golan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Hematology

Anti-angiogenesis for cancer: Current status and prospects

Massimo Russo et al.

THROMBOSIS RESEARCH (2018)

Review Oncology

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

Panagiotis Kotsantis et al.

CANCER DISCOVERY (2018)

Article Medicine, General & Internal

Talazoparib in Patients with Advanced Breast Cancer and a Germline BRCA Mutation

Jennifer K. Litton et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Replication Stress: An Achilles' Heel of Glioma Cancer Stem-like Cells

Meredith A. Morgan et al.

CANCER RESEARCH (2018)

Review Genetics & Heredity

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Herve Techer et al.

NATURE REVIEWS GENETICS (2017)

Review Cell Biology

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

Arnab Ray Chaudhuri et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Cell Biology

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

Yves Pommier et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Article Medicine, Research & Experimental

ABT-888 enhances cytotoxic effects of temozolomide independent of MGMT status in serum free cultured glioma cells

Rutger K. Balvers et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

Review Pharmacology & Pharmacy

Trapping Poly(ADP-Ribose) Polymerase

Yuqiao Shen et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Editorial Material Biochemistry & Molecular Biology

PARP inhibitors and IR join forces to strike glioblastoma-initiating cells

N. Lugli et al.

CELL DEATH AND DIFFERENTIATION (2014)

Article Oncology

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

Junko Murai et al.

MOLECULAR CANCER THERAPEUTICS (2014)

Article Genetics & Heredity

DNA repair mechanisms in dividing and non-dividing cells

Teruaki Iyama et al.

DNA REPAIR (2013)

Article Cell Biology

The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines

Elisa Lavarone et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)

Article Oncology

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai et al.

CANCER RESEARCH (2012)

Review Cell Biology

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

Bryan A. Gibson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage

Ismail Hassan Ismail et al.

NUCLEIC ACIDS RESEARCH (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Biochemistry & Molecular Biology

Cancer epigenetics reaches mainstream oncology

Manuel Rodriguez-Paredes et al.

NATURE MEDICINE (2011)

Article Multidisciplinary Sciences

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

Danny M. Chou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Oncology

PARP inhibition: PARP1 and beyond

Michele Rouleau et al.

NATURE REVIEWS CANCER (2010)

Review Oncology

DNA repair and cancer stem-like cells - Potential partners in glioma drug resistance?

Tor-Christian Aase Johannessen et al.

CANCER TREATMENT REVIEWS (2008)

Article Pharmacology & Pharmacy

Chromatin-modifying enzymes as therapeutic targets – Part 2

Brian R Keppler et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2008)

Article Multidisciplinary Sciences

HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

Shanthi Adimoolam et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Analysis of gene expression and chemoresistance of CDI33+ cancer stem cells in glioblastoma

Gentao Liu et al.

MOLECULAR CANCER (2006)

Article Biochemistry & Molecular Biology

Poly(ADP-ribose)polymerase inhibition decreases angiogenesis

Mohanraj Rajesh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Biochemistry & Molecular Biology

Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

Mohanraj Rajesh et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Article Biochemistry & Molecular Biology

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

BE Bernstein et al.

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)