Journal
PHARMACOLOGICAL REPORTS
Volume 75, Issue 1, Pages 69-84Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s43440-022-00426-4
Keywords
Ethanol metabolism; Breast cancer; Breast cancer risk factors; Alcohol and oestrogens; Preventive factors
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Breast cancer is a leading cause of death in women worldwide, and alcohol plays a significant role in the development of tumors. This paper discusses the metabolism of alcohol and the mechanisms behind mammary tumorigenesis caused by alcohol. It presents numerous signaling pathways involved in neoplastic transformation following alcohol consumption in women and describes primary and secondary prevention, phytochemicals, synthetic chemicals, specific enzyme inhibitors, and selective receptor modulators.
Breast cancer is one of the main causes of death in women worldwide. In women, breast cancer includes over half of all tumours caused by alcohol. This paper discusses both ethanol metabolism and the mechanisms of mammary tumourigenesis caused by alcohol. Numerous signalling pathways in neoplastic transformation following alcohol consumption in women have been presented. In addition, primary and secondary prevention, phytochemicals, synthetic chemicals, specific inhibitors of enzymes and selective receptor modulators have been described.
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