4.6 Article

Asiaticoside reverses M2 phenotype macrophage polarization-evoked osteosarcoma cell malignant behaviour by TRAF6/NF-κB inhibition

Related references

Note: Only part of the references are listed.
Article Neurosciences

The m6A methyltransferase METTL3 promotes LPS-induced microglia inflammation through TRAF6/NF-κB pathway

Linbao Wen et al.

Summary: This study found that METTL3 methyltransferase promotes microglial inflammation by activating the TRAF6-NF-κB pathway.

NEUROREPORT (2022)

Article Plant Sciences

Ethanol extract of Centella asiatica alleviated dextran sulfate sodium-induced colitis: Restoration on mucosa barrier and gut microbiota homeostasis

Huibiao Li et al.

Summary: The study found that Centella asiatica ethanol extract significantly reduced inflammation in mice with UC, alleviating symptoms of colitis and potentially serving as an effective treatment in clinical practice.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Astragaloside IV antagonizes M2 phenotype macrophage polarization-evoked ovarian cancer cell malignant progression by suppressing the HMGB1-TLR4 axis

Xue Wang et al.

Summary: Astragaloside IV inhibits M2 macrophage polarization and suppresses malignant potential in ovarian cancer cells, potentially through HMGB1-TLR4 signaling pathway.

MOLECULAR IMMUNOLOGY (2021)

Article Oncology

Asiaticoside inhibits epithelial-mesenchymal transition and stem cell-like properties of pancreatic cancer PANC-1 cells by blocking the activation of p65 and p38MAPK

Yonggang He et al.

Summary: Asiaticoside (ATS) inhibits proliferation, epithelial-mesenchymal transition (EMT), and stem cell-like properties of pancreatic cancer cells by blocking phosphorylation of p38MAPK and nuclear factor-kappa B (NF-kappa B)/p65 in PANC-1 cells.

JOURNAL OF GASTROINTESTINAL ONCOLOGY (2021)

Article Oncology

Anticancer activity of ursolic acid on retinoblastoma cells determined by bioinformatics analysis and validation

Dan Zhou et al.

Summary: The research found that ursolic acid inhibits the proliferation, migration, and invasion of retinoblastoma (Rb) cells by targeting stearoyl-CoA desaturase (SCD). This provides a new scientific basis for targeted therapy of Rb.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Review Oncology

The role of tumor-associated macrophages in osteosarcoma progression - therapeutic implications

Qingshan Huang et al.

Summary: Osteosarcoma treatment has not significantly improved in recent years, leading to a focus on the tumor microenvironment (TME) and the role of tumor-associated macrophages (TAMs). TAMs may play important roles in tumorigenesis, angiogenesis, immunosuppression, drug resistance, and metastasis, making them attractive therapeutic targets for improving the prognosis of osteosarcoma. Targeting TAMs as a complementary therapy is expected to enhance the efficacy of current treatment modalities.

CELLULAR ONCOLOGY (2021)

Article Cell Biology

Identification of abnormally high expression of POGZ as a new biomarker associated with a poor prognosis in osteosarcoma

Sikuan Zheng et al.

Summary: POGZ is an important gene associated with the prognosis of osteosarcoma, and its overexpression is related to poor prognosis. Knockdown of POGZ arrests OS cells in the cell cycle, leading to decreased cell proliferation, invasion, and migration.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2021)

Review Pharmacology & Pharmacy

Macrophage M1/M2 polarization

Chen Yunna et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis

Elmira Karami et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Review Veterinary Sciences

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

Siobhan Simpson et al.

ACTA VETERINARIA SCANDINAVICA (2017)

Review Oncology

New molecular insights into osteosarcoma targeted therapy

Jilong Yang et al.

CURRENT OPINION IN ONCOLOGY (2013)

Article Pharmacology & Pharmacy

Olmesartan decreases IL-1β and TNF-α levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis

Aurigena Antunes Araujo et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2013)

Article Cell Biology

TRAF6 regulates proliferation, apoptosis, and invasion of osteosarcoma cell

Qingbing Meng et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2012)

Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

Article Multidisciplinary Sciences

Distinct molecular mechanism for initiating TRAF6 signalling

H Ye et al.

NATURE (2002)