Prospective Evaluation of the Fungitell® (1→3) Beta-D-Glucan Assay as a Diagnostic Tool for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplantation: A Report from the Children's Oncology Group

Review Infectious Diseases

Comparative accuracy of 1,3 beta-D glucan and galactomannan for diagnosis of invasive fungal infections in pediatric patients: a systematic review with meta-analysis

Shreya Singh et al.

Summary: In this study, the diagnostic accuracy of 1,3-beta-D glucan (BDG) and galactomannan (GM) for invasive fungal infections (IFI) in pediatric patients was compared. The results showed that GM had better accuracy over BDG, but combining both tests improved specificity at the cost of sensitivity.

MEDICAL MYCOLOGY (2021)

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Article Microbiology

Diagnostic Performance of (1→3)-β-D-Glucan Alone and in Combination with Aspergillus PCR and Galactomannan in Serum of Pediatric Patients after Allogeneic Hematopoietic Stem Cell Transplantation

Jan Springer et al.

Summary: This study found that BDG, GM, and Aspergillus-specific DNA testing can assist in diagnosing invasive aspergillosis in pediatric patients. BDG had high sensitivity but low specificity, suggesting the need for optimizing cutoff values or confirming test results with alternative methods.

JOURNAL OF FUNGI (2021)

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Article Infectious Diseases

A Randomized Trial of Caspofungin vs Triazoles Prophylaxis for Invasive Fungal Disease in Pediatric Allogeneic Hematopoietic Cell Transplant

Christopher C. Dvorak et al.

Summary: This study showed that prophylaxis with caspofungin did not significantly reduce the cumulative incidence of early proven or probable invasive fungal disease (IFD) compared with triazoles in pediatric patients undergoing hematopoietic cell transplantation. Future efforts should focus on reducing the morbidity and mortality related to IFD.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2021)

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Article Dermatology