4.5 Article

Confirmation of lung adenocarcinoma as the primary cancer with detection of EML4-ALK rearrangement using next-generation sequencing: a case study

Journal

PATHOLOGY RESEARCH AND PRACTICE
Volume 238, Issue -, Pages -

Publisher

ELSEVIER GMBH
DOI: 10.1016/j.prp.2022.154105

Keywords

Carcinoma of unknown primary site; EML4-ALK rearrangement; Next generation sequencing; Immunohistochemistry; Lung adenocarcinoma

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Funding

  1. Research Fund of Guangzhou Xinhua University [2019KYYB06]

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This study reports a female patient with carcinoma of unknown primary site, who was later confirmed to have lung adenocarcinoma as the primary cancer through NGS. The patient initially responded well to crizotinib treatment but developed resistance after 5 months. Switching to alectinib, a second-generation ALK inhibitor, led to an excellent therapeutic response. This research suggests the use of NGS to detect ALK rearrangement in patients with carcinoma of unknown primary site and highlights the importance of considering resistance to ALK inhibitors in personalized precision medicine.
We report a female patient, who presented as a carcinoma of unknown primary site with multiple tumors in breast, lung, stomach, and ovary, was confirmed to be lung adenocarcinoma as primary cancer through detecting EML4-ALK rearrangement by the next generation sequencing (NGS). The patient was treated with crizotinib and resulted in significant regression of the primary and metastatic tumors, but resistance to crizotinib was developed 5 months after the treatment. Targeted therapy was, therefore, switched to alectinib, one of the second -generation of anaplastic lymphoma kinase (ALK) inhibitors, with excellent therapeutic response till November 16th, 2021. This study suggested that NGS be recommended to detect ALK rearrangement in the patients with carcinoma of unknown primary site, and that resistance to targeted therapy with ALK inhibitors should be considered for personalized precision medicine.

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