KAT7 promoted gastric cancer progression through promoting YAP1 activation

Lysine acetyltransferase 7 (KAT7) was upregulated in gastric cancer (GC) patient tissues, and associated with poor prognosis and metastasis. However, its specific role in GC remains unclear. This study aimed to annotate the role of KAT7 in GC cells. The results showed that the overexpression of KAT7 promoted cell growth, migration, and invasion, while KAT7 inhibition has the opposite effect. Besides, KAT7 participated in cell cycle phase distribution and epithelial-mesenchymal transition (EMT) process of GC cells. In addition, KAT7 promoted the transcription and nuclear translocation of Yes-associated protein 1 (YAP1) in MKN45 cells. Silence of YAP1 partly reversed the promoting effect of KAT7 on GC cells progression. In summary, this study indicates that KAT7 promoted GC cells progression through promoting YAP1 activation, contributes to understand the specific role of KAT7 in GC.

Automated summary

This study found that KAT7 is upregulated in gastric cancer and is associated with poor prognosis and metastasis. Overexpression of KAT7 promotes the growth, migration, and invasion of gastric cancer cells, and is involved in cell cycle distribution and epithelial-mesenchymal transition. Additionally, KAT7 promotes the transcription and nuclear translocation of YAP1, and silencing YAP1 partially reverses the promoting effect of KAT7 on gastric cancer cell progression.