Toxoplasma gondii infection in goats: serological, pathological, and clinical monitoring during gestation

This study aimed to evaluate Toxoplasma gondii infection in pregnant goats. The goats were divided into two groups: group one (G1) comprised of 31 pregnant goats naturally infected with T. gondii, and group two (G2) comprised of seven uninfected pregnant goats from a flock with a history of abortion due to toxoplasmosis. Serological investigation, ultrasonography, and clinical testing were performed on all goats during gestation. Serum samples from goats and their offspring (precolostral) were collected to evaluate the vertical transmission of T. gondii. Samples from placentas and aborted fetuses were also collected for molecular and histopathological analysis. Results showed that in G1, estrus recurrence occurred in 22.6% (7/31) of the goats, embryonic death in 3.3% (1/31), and abortion in 19.4% (6/31). An increase in anti-T. gondii antibodies was observed in G1 goats at day 150 of pregnancy. T. gondii DNA was detected in 42.8% (3/7) of aborted fetuses and was associated with histopathological lesions caused by this parasite. Moreover, toxoplasmosis in field conditions caused by genotype ToxoDB #1 in pregnant goats resulted in severe reproductive loss in the flock.

Automated summary

This study evaluated Toxoplasma gondii infection in pregnant goats and found that it significantly affected reproductive health, leading to estrus recurrence, embryonic death, and abortion. The presence of anti-T. gondii antibodies in serum samples from goats and their offspring, along with the detection of T. gondii DNA in aborted fetuses and associated histopathological lesions, confirmed vertical transmission. In addition, the study determined that toxoplasmosis caused by genotype ToxoDB #1 resulted in severe reproductive loss in the goat flock.