☆ 4.6 Article

Development of an Efficient New Route to PPARδ Agonist Fonadelpar: Formation of the C-C Bond by Claisen Condensation

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2022)

Related references

Note: Only part of the references are listed.

Article Chemistry, Organic

Synthesis, antimicrobial activity, and molecular docking studies of new fused pyrimidinethiones

Ahmed H. H. Hussien et al.

Summary: In this study, a series of new compounds were synthesized and their in vitro antibacterial activity against pathogenic bacteria was evaluated. Molecular docking studies were conducted to determine the binding mode and energy of active compounds with the target protein of E. coli.

JOURNAL OF HETEROCYCLIC CHEMISTRY (2022)

Add to Collection

Article Ophthalmology

The role of peroxisome proliferator-activated receptors in healthy and diseased eyes

Paulina Escandon et al.

Summary: PPARs are a family of nuclear receptors that play essential roles in modulating cell differentiation, inflammation, and metabolism, and have been linked to various eye diseases. Studies have shown different subtypes of PPARs have varying effects on ocular homeostasis and potential therapeutic implications for eye diseases, highlighting the need for further research on their role in ocular pathologies.

EXPERIMENTAL EYE RESEARCH (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

PPAR control of metabolism and cardiovascular functions

David Montaigne et al.

Summary: Novel PPAR agonists offer new opportunities for managing metabolic and cardiovascular diseases by regulating gene expression, lipid metabolism, insulin sensitivity, glucose metabolism, and cardiovascular health. Activation of PPARs by specific ligands can have antiatherogenic, anti-inflammatory, and metabolic benefits, making them important therapeutic targets in the treatment of various diseases.

NATURE REVIEWS CARDIOLOGY (2021)

Add to Collection

Article Chemistry, Organic

Divergent and Regioselective Synthesis of Pyrazolo[1,5-a]pyridines and Imidazo[1,5-a]pyridines

Katrina M. Mennie et al.

Summary: The study reports a regioselective method for synthesizing pyrazolo[1,5-a]pyridines, as well as a protocol for the regioselective formation of imidazo[1,5-a]pyridines. These transformations allow for the rapid and selective formation of two important heterocyclic motifs from a common intermediate.

ORGANIC LETTERS (2021)

Add to Collection

Article Chemistry, Applied

Concise and Efficient Synthesis of [6]-Paradol

Xiang Shi et al.

Summary: In this study, an efficient synthesis of [6]-paradol was achieved in four steps with a 72.0% overall yield. The method utilized commercially available materials and allowed for convenient isolation with multiple crystallization without the need for column chromatography, resulting in a high-purity product of over 99.2% purity that is suitable for large-scale synthesis.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2021)

Add to Collection

Article Chemistry, Medicinal

Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective

Tara Man Kadayat et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Scope and Mechanism of a True Organocatalytic Beckmann Rearrangement with a Boronic Acid/Perfluoropinacol System under Ambient Conditions

Xiaobin Mo et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection

Article Chemistry, Medicinal

Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety

Jin Xie et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Add to Collection

Article Chemistry, Medicinal

Natural products as sources of new fungicides (III): Antifungal activity of 2,4-dihydroxy-5-methylacetophenone derivatives

Wei Shi et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Add to Collection

Article Chemistry, Medicinal

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

Francesca Curreli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Add to Collection

Article Chemistry, Multidisciplinary

Total Synthesis and Stereochemical Assignment of (±)-Sorbiterrin A

Chao Qi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Add to Collection

Article Chemistry, Applied

Process Research on a Phenoxybutyric Acid LTB4 Receptor Antagonist. Efficient Kilogram-Scale Synthesis of a 3,5-Bisarylphenol Core

Lianhe Shu et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists

Shogo Sakuma et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Add to Collection

Article Chemistry, Medicinal

Synthesis of a novel human PPAR delta selective agonist and its stimulatory effect on oligodendrocyte differentiation

Shogo Sakuma et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Add to Collection

Article Chemistry, Organic

Thiazole analogs of chalcones, capable of functionalization at the heterocyclic nucleus

V. N. Kotlyar et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2010)

Add to Collection

Article Chemistry, Medicinal

Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors α and β

Frederik Roelens et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

Add to Collection

© Peeref 2019-2024. All rights reserved.