Journal
ORGANIC LETTERS
Volume 24, Issue 40, Pages 7323-7327Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02790
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Funding
- National Natural Science Foundation of China
- [22278370]
- [21676252]
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In this study, a metal-free synthesis of imidized methylene cyclobutane derivatives was reported using a strain-release driven addition reaction of [1.1.1]propellane. The methylene cyclobutyl cation intermediate generated by protonation of [1.1.1]propellane was trapped by nitriles to form a nitrilium ion intermediate, which subsequently reacted with carboxylic acids to produce imidized methylene cyclobutene derivatives via a Mumm-type rearrangement.
Herein, we report the metal-free synthesis of imidized methylene cyclobutane derivatives via a strain-release driven addition reaction of [1.1.1]propellane. Using this strategy, the methylene cyclobutyl cation intermediate generated by protonation of [1.1.1]propellane was found to be trapped by nitriles to form a nitrilium ion intermediate, which subsequently reacted with carboxylic acids to produce imidized methylene cyclobutene derivatives via a Mumm-type rearrangement.
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