Visible-Light-Initiated Difunctionalization of Quinoxalin-2(1H)-ones with Acyloxy Nitroso Compounds

Herein, a photoinitiated radical relay reaction of quinoxalin-2(1H)-ones, with acyloxy nitroso compounds as a source of radicals, is described. Although the C-H functionalization of quinoxalin-2(1H)-ones has been investigated, its difunctionalization, the simultaneous construction of C-C and N-N bonds directly via the radical relay reaction, has rarely been reported. Moreover, the obtained products underwent sequential reactions to access C7-NO2 of quinoxalin-2(1H)-ones under mild conditions.

Automated summary

In this study, a photoinitiated radical relay reaction of quinoxalin-2(1H)-ones using acyloxy nitroso compounds as radical sources is described. The difunctionalization of quinoxalin-2(1H)-ones, involving the simultaneous construction of C-C and N-N bonds via radical relay reaction, is rarely reported. Furthermore, the obtained products undergo sequential reactions to access C7-NO2 of quinoxalin-2(1H)-ones under mild conditions.