Journal
ORGANIC LETTERS
Volume 24, Issue 34, Pages 6326-6330Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02544
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Funding
- NSFC [21901169, 21931006, 21921002]
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This study reports a three-component auto-tandem reaction catalyzed by palladium, which efficiently constructs a variety of organic compounds. The reaction demonstrates high chemo- and regioselectivity, achieving 1,3,4-trifunctionalization of the 1,3-enyne motif.
Here we report a three-component auto-tandem reaction of 1,3-enyne-tethered carbonyls, organoboronic reagents, and suitable nucleophiles catalyzed by palladium, proceeding through consecutive intramolecular vinylogous addition, Suzuki coupling, and allylic alkylation. This process exhibited high chemo-and regioselectivity with 1,3,4-trifunctionalization of the 1,3enyne motif, and a wide range of 2H-chromenes, 1,2-dihydroquinolines, benzo[b]oxepines, 1,7-annulated indoles, and other frameworks were efficiently constructed in fair to good yields and E/Z selectivity.
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