Journal
ORGANIC LETTERS
Volume 24, Issue 40, Pages 7288-7293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02685
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Funding
- Natural Science Foundation of Zhejiang Province
- K. C. Wong Education Foundation
- [LY19B020016]
- [GJTD-2020-08]
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A novel ruthenium-catalyzed method using hydroxyl as a directing group has been developed for the selective C-H activation and annulation of 1-naphthols with CF3-substituted imidoyl sulfoxonium ylides. This strategy provides a facile and efficient route to diverse trifluoromethyl-containing 2,3-dihydrobenzo[de]chromen-2-amines, with notable advantages including readily available materials, excellent regioselectivity, good functional group compatibility, and scalability.
A ruthenium-catalyzed peri-selective C-H activation and annulation of 1- naphthols with CF3-substituted imidoyl sulfoxonium ylides that uses hydroxyl as a weakly coordinating directing group is disclosed. The strategy provides a facile and practical route to diverse trifluoromethyl-containing 2,3-dihydrobenzo[de]chromen-2-amines with high efficiency. Notable advantages of this protocol include readily available materials, excellent regioselectivity, good functional group compatibility, and scalability.
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