Journal
ORGANIC LETTERS
Volume 24, Issue 40, Pages 7470-7475Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c03124
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Funding
- National Natural Science Foundation of China [21971081, 22171099, 21820102003, 21901080, 91956201]
- School of Chemistry and Chemical Engineering, Henan Normal University [2021YB02]
- Program of Introducing Talents of Discipline to Universities of China(111 Program) [B17019]
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A three-component 1,2-aminooxygenation reaction of 1,3-dienes by dual photoredox and copper catalysis is described. This reaction utilizes N-aminopyridinium salts as N-centered radical precursors and nucleophilic alcohols as oxygen sources, providing modular and practical access to 1,2-aminoalkoxylation products with high yields and regioselectivity.
A three-component 1,2-aminooxygenation reaction of 1,3-dienes by dual photoredox and copper catalysis is described. This protocol uses N-aminopyridinium salts as N-centered radical precursors and nucleophilic alcohols as oxygen sources, providing modular and practical access to 1,2-aminoalkoxylation products with good yields and regioselectivity. Preliminary mechanistic studies support the radical property of the reaction and the involvement of N-centered radical intermediates.
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