Journal
ORGANIC LETTERS
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02880
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Funding
- National Key Research and Develop- ment Project of China [2021YFC2100100]
- National Natural Science Foundation of China [21901123, 32171724]
- Natural Science Foundation of Jiangsu Province [BK20190694]
- Jiangsu Specially Appointed Professor Plan
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This paper presents a simple synthesis method for the chemo-, regio-, and stereoselective preparation of beta-methylthio vinyl triflates by the reaction between alkynes and dimethyl(methylthio)sulfonium trifluoromethanesulfonate under neutral and extremely simple conditions.
Vinyl triflates are commonly employed as electrophilic vinyl sources in complex synthesis. The triflation of enolates is commonly required for the preparation of vinyl triflates, generally under strongly basic conditions. Herein, the reaction between alkynes and dimethyl(methylthio)sulfonium trifluoromethanesulfonate is presented, which leads to the development of a facile synthesis of beta-methylthio vinyl triflates in a chemo-, regio-, and stereoselective manner under neutral and extremely simple conditions.
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