4.8 Article

Ru-Catalyzed Enantioselective Hydrogenation of Diaryl 1,4-Diketones: Synthesis of Chiral 1,4-Diarylbutane-1,4-Diols

Journal

ORGANIC LETTERS
Volume 24, Issue 41, Pages 7512-7516

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02721

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Funding

  1. National Natural Science Foundation of China
  2. [22071151]

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Asymmetric hydrogenation of diaryl 1,4-diketones was achieved using trans-RuCl2[(S)-BINAP)][(S)-Daipen] as the catalyst, affording excellent enantio- and diastereoselectivities (up to >99% ee and de). This procedure provides a convenient and efficient synthetic method for chiral 1,4diarylbutane-1,4-diols, which are important intermediates for a variety of chiral auxiliaries and ligands.
Asymmetric hydrogenation of diaryl 1,4-diketones was achieved by using trans-RuCl2[(S)-BINAP)][(S)-Daipen] as the catalyst and the reaction gave rise to excellent enantio-and diastereoselectivities (up to >99% ee and de). This procedure provides a convenient and efficient synthetic method for chiral 1,4diarylbutane-1,4-diols, which are important intermediates for a variety of chiral auxiliaries and ligands.

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