Journal
ORGANIC LETTERS
Volume 24, Issue 41, Pages 7512-7516Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02721
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Funding
- National Natural Science Foundation of China
- [22071151]
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Asymmetric hydrogenation of diaryl 1,4-diketones was achieved using trans-RuCl2[(S)-BINAP)][(S)-Daipen] as the catalyst, affording excellent enantio- and diastereoselectivities (up to >99% ee and de). This procedure provides a convenient and efficient synthetic method for chiral 1,4diarylbutane-1,4-diols, which are important intermediates for a variety of chiral auxiliaries and ligands.
Asymmetric hydrogenation of diaryl 1,4-diketones was achieved by using trans-RuCl2[(S)-BINAP)][(S)-Daipen] as the catalyst and the reaction gave rise to excellent enantio-and diastereoselectivities (up to >99% ee and de). This procedure provides a convenient and efficient synthetic method for chiral 1,4diarylbutane-1,4-diols, which are important intermediates for a variety of chiral auxiliaries and ligands.
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