4.8 Article

Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction

Journal

ORGANIC LETTERS
Volume 24, Issue 43, Pages 7924-7927

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02996

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Funding

  1. EPSRC [EP/P026990/1]
  2. Royal Thai Government

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A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is tolerant to functional groups and heterocycle substituents, making it applicable for the synthesis of anti-inflammatory drugs and enzyme-binding compounds in bacteria.
A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.

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