Difluoromethylsulfonyl Imidazolium Salt for Difluoromethylation of Alkenes

Herein, we describe the design and synthesis of a difluoromethylsulfonyl imidazolium salt, which can act as a radical difluoromethylation reagent to achieve the challenging amino-and oxy-difluoromethylation of alkenes. Notably, the three steps for the synthesis of the imidazolium salt do not require any tedious distillation or column chromatography purification process, and the amino-and oxy-difluoromethylation paths are simply determined by the selection of reaction solvents.

Automated summary

Here, we report the design and synthesis of a difluoromethylsulfonyl imidazolium salt, which serves as a radical difluoromethylation reagent for achieving amino- and oxy-difluoromethylation of alkenes. Importantly, the synthesis of the imidazolium salt can be accomplished without the need for distillation or column chromatography purification, and the amino- and oxy-difluoromethylation pathways are determined by the choice of reaction solvents.