Organocatalytic Activation of Inert Hydrosilane for Peptide Bond Formation

We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural alpha-amino acids, beta-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OCH(CF3)(2)](3) as a catalyst was sufficient to guarantee a consistently high yield of the resulting peptide. This method facilitates the sustainable utilization of natural resources by using a catalyst and an auxiliary based on earth-abundant silicon.

Automated summary

We describe the development of a reliable catalytic protocol for peptide bond formation that is generally applicable to natural and unnatural alpha-amino acids, beta-amino acids, and peptides bearing various functional groups. A 10 mol % loading of HSi[OCH(CF3)(2)](3) as a catalyst was sufficient to guarantee a consistently high yield of the resulting peptide. This method facilitates the sustainable utilization of natural resources by using a catalyst and an auxiliary based on earth-abundant silicon.