Catalysis Driven Six-Step Synthesis of Apratoxin A Key Polyketide Fragment

Apratoxin A is a potent anticancer natural product whose key polyketide fragment constitutes a considerable challenge for organic synthesis, with five prior syntheses requiring 12 to 20 steps for its preparation. By combining different redoxeconomical catalytic stereoselective transformations, the key polyketide fragment could be rapidly prepared. Followed by a site selective protection of the diol, this strategy enables the preparation of the apratoxin A fragment in only six steps, representing the shortest route to this polyketide.

Automated summary

Apratoxin A is a potent anticancer natural product. The synthesis of its key compound has always been a challenge in organic chemistry. By combining different catalytic reactions, the key polyketide fragment can be prepared rapidly. This method allows for the preparation of the apratoxin A fragment in just six steps, representing the shortest route to this polyketide.