Journal
ORGANIC LETTERS
Volume 24, Issue 40, Pages 7300-7304Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02705
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Funding
- Applied Basic Research Fund project of Guangdong Province of China [2019A1515110918]
- Science and Technology Planning Program of Zhanjiang [2021A05247]
- Key Discipline Construction Project of Guangdong Medical University [4SG22004G]
- Scientific Research Fund of Hunan Provincial Education Department [21A0613]
- Doctoral Research Fund of Hunan University of Medicine [2020122005]
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CuX was used as a simple dual catalyst strategy for the tandem transformations of fused oxazolo[2,3-b][1,3]oxazines. Copper catalyzed the CuAAC/ring cleavage/[4+2] annulation reaction using terminal ynones, sulfonyl azides, and nitriles, while halogen catalyzed the ring cleavage and [2+3] annulation of oxiranes to form the final fused products. This study provides a four-component, one-pot strategy for synthesizing complex fused heterocycles from simple ingredients and expands the application of CuAAC in organic synthesis.
CuX as a simple dual catalyst strategy that promotes the tandem transformations of fused oxazolo[2,3-b][1,3]oxazines has been developed. Copper catalyzed terminal ynones, sulfonyl azides, and nitriles for the CuAAC/ring cleavage/[4+2] annulation reaction, while the halogen catalyzed ring cleavage and [2+3] annulation of oxiranes to form the final fused products. This study provides a four-component, one-pot strategy for synthesizing complex fused heterocycles from simple ingredients and expands the application of CuAAC in organic synthesis.
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