Electromagnetic Mill Promoted Mechanochemical Solvent-Free Palladium-Catalyzed Borylation of Aryl Bromides

The electromagnetic mill (EMM) promoted mechanochemical solvent-free palladium-catalyzed borylation of aryl bromides using low palladium catalyst loading (0.05-0.5 mol %) was realized. This protocol exhibits many advantages, such as broad substrate scope, good functional group tolerance, short reaction times, no additional heating, and practical gram-scale synthesis. This EMM system not only showed excellent prospects for industrial application but also unlocked broad areas of solvent-free solid-state metal-catalyzed syntheses.

Automated summary

The electromagnetic mill (EMM) has enabled the palladium-catalyzed borylation of aryl bromides under solvent-free conditions with low palladium catalyst loading (0.05-0.5 mol %). This method offers numerous advantages, including a wide substrate scope, tolerance towards various functional groups, short reaction times, no additional heating requirements, and practical gram-scale synthesis. The EMM system not only shows promising potential for industrial applications, but also expands the possibilities of solvent-free solid-state metal-catalyzed syntheses.