Journal
ORGANIC LETTERS
Volume 24, Issue 36, Pages 6566-6570Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02528
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Funding
- National Natural Science Foundation of China [NSF 22171114, 21772075]
- Shandong Provincial Natural Science Foundation [ZR2019IFG004]
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Here, we report a novel and efficient photoredox catalytic radical addition/defluoroalkylation coupling reaction between primary amines and trifluoromethyl-substituted alkenes. A series of gem-difluoroalkenes were synthesized through C-N bond cleavage of α-3°, α-2°, and α-1° amines under visible light irradiation. This reaction exhibits a broad substrate scope and excellent functional group tolerance.
Herein, we describe a novel and efficient photoredox catalytic radical addition/defluoroalkylation coupling reaction between primary amines and trifluoromethyl-substituted alkenes. A series of gem-difluoroalkenes were synthesized via C-N bond cleavage of alpha-3 degrees , alpha-2 degrees, and alpha-1 degrees amines under visible light irradiation. This reaction is characterized by a broad substrate scope and good functional group tolerance.
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