4.8 Article

Photoredox Catalyzed Thioformylation of Terminal Alkynes Using Nitromethane as a Formyl Source

Journal

ORGANIC LETTERS
Volume 24, Issue 36, Pages 6658-6663

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c02695

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Funding

  1. DST-SERB [000850/2021]
  2. DST
  3. CSIR

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A photoredox thioformylation method using nitromethane as a formyl anion equivalent has been developed for the synthesis of (E)-1,2-difunctionalized acrylaldehyde from terminal alkynes. This strategy introduces an adaptable aldehyde function across an alkyne and provides a new route to synthesizing alpha-alkyl/aryl aldehydes.
A photoredox thioformylation of terminal alkynes using nitromethane as a formyl anion equivalent, thereby leading to the synthesis of (E)-1,2-difunctionalized acrylaldehyde, has been described. The current strategy introduces an adaptable aldehyde function across an alkyne and offers a new route to synthesizing alpha-alkyl/aryl aldehydes.

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