Photoredox Catalyzed Thioformylation of Terminal Alkynes Using Nitromethane as a Formyl Source

A photoredox thioformylation of terminal alkynes using nitromethane as a formyl anion equivalent, thereby leading to the synthesis of (E)-1,2-difunctionalized acrylaldehyde, has been described. The current strategy introduces an adaptable aldehyde function across an alkyne and offers a new route to synthesizing alpha-alkyl/aryl aldehydes.

Automated summary

A photoredox thioformylation method using nitromethane as a formyl anion equivalent has been developed for the synthesis of (E)-1,2-difunctionalized acrylaldehyde from terminal alkynes. This strategy introduces an adaptable aldehyde function across an alkyne and provides a new route to synthesizing alpha-alkyl/aryl aldehydes.