MicroLED neural probe for effective in vivo optogenetic stimulation

The MicroLED probe enables optogenetic control of neural activity in spatially separated brain regions. Understanding its heat generation characteristics is important. In this study, we investigated the temperature rise (Delta T) characteristics in the brain tissue using a MicroLED probe. The.T strongly depended on the surrounding environment of the probe, including the differences between the air and the brain, and the area touching the brain tissue. Through animal experiments, we suggest an in situ temperature monitoring method using temperature dependence on electrical characteristics of the MicroLED. Finally, optical stimulation by MicroLEDs proved effective in controlling optogenetic neural activity in animal models. (c) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement

Automated summary

This study investigates the temperature rise characteristics in brain tissue using a MicroLED probe. The findings show that the temperature rise strongly depends on the surrounding environment and the area of contact. Additionally, a new method for in situ temperature monitoring using the electrical characteristics of the MicroLED is proposed. Furthermore, the study demonstrates the effective control of optogenetic neural activity through optical stimulation by MicroLEDs.