Nonalcoholic fatty liver disease and risk of intracerebral hemorrhage

Review Gastroenterology & Hepatology

Nonalcoholic fatty liver disease and risk of incident hypertension: a systematic review and meta-analysis

Stefano Ciardullo et al.

Summary: This systematic review and meta-analysis found that NAFLD is associated with a moderately increased risk of incident hypertension, with further investigation needed into the role of NAFLD severity on hypertension development.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Non-alcoholic fatty liver disease increases risk of carotid atherosclerosis and ischemic stroke: An updated meta-analysis with 135,602 individuals

Ansel Shao Pin Tang et al.

Summary: This meta-analysis shows that the progressive increase of steatosis in NAFLD significantly increases the risk of carotid atherosclerosis and stroke development. More than a third of the patients suffered from carotid atherosclerosis, highlighting the quintessential role of routine assessment of carotid atherosclerosis in NAFLD.

CLINICAL AND MOLECULAR HEPATOLOGY (2022)

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Article Clinical Neurology

Severity of Nonalcoholic Fatty Liver Disease and Risk of Future Ischemic Stroke Events

Jie Xu et al.

Summary: The severity of NAFLD is associated with a higher risk of future ischemic stroke events.

STROKE (2021)

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Review Hematology

Translational insight into prothrombotic state and hypercoagulation in nonalcoholic fatty liver disease

Alessandro Ciavarella et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is a pathological condition that ranges from fatty liver (FL) to chronic steatohepatitis (NASH), liver cirrhosis, and eventually to hepatocellular carcinoma (HCC). Patients with NAFLD have a higher risk of cardiovascular events and thromboembolism, which is independent of metabolic diseases commonly associated with NAFLD.

THROMBOSIS RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Rohit Loomba et al.

Summary: NAFLD and NASH are leading chronic liver diseases worldwide, causing progressive liver injury that can lead to cirrhosis and hepatocellular carcinoma. These diseases are associated with hepatic glucose and lipid metabolism, and are influenced by genetic, epigenetic, and environmental factors.

CELL (2021)

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Review Gastroenterology & Hepatology

The complex link between NAFLD and type 2 diabetes mellitus - mechanisms and treatments

Giovanni Targher et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) have a complex relationship with each other, influencing the risk of adverse clinical outcomes. The severity of NAFLD is directly related to the risk of developing T2DM, while improvement of NAFLD may lower the risk of T2DM.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology