4.8 Article

Disease-associated inosine misincorporation into RNA hinders translation

Related references

Note: Only part of the references are listed.
Review Genetics & Heredity

Inosine in Biology and Disease

Sundaramoorthy Srinivasan et al.

Summary: Inosine plays crucial roles in biology, impacting gene translation, RNA fate, and other processes. Modification of adenosine to inosine in tRNAs and mRNAs can significantly affect codon recognition and polypeptide translation. In addition, inosine is found in non-coding and exogenous RNAs, serving as a molecular messenger in cell signaling pathways.

GENES (2021)

Article Biochemistry & Molecular Biology

Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins

Adrian Gabriel Torres et al.

Summary: The modification of adenosine to inosine at the 134th position of tRNA anticodons is essential for the translation of specific low-complexity proteins in eukaryotes, which require the cognate codons translated by 134-tRNAs for their synthesis.

NUCLEIC ACIDS RESEARCH (2021)

Article Multidisciplinary Sciences

Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping

Aldema Sas-Chen et al.

NATURE (2020)

Article Medicine, Research & Experimental

Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy

Yuichiro Koga et al.

JCI INSIGHT (2020)

Article Biochemistry & Molecular Biology

Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs

Mehmet Tardu et al.

ACS CHEMICAL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression

Julie Lorent et al.

EMBO JOURNAL (2019)

Article Multidisciplinary Sciences

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels

Kaalak Reddy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemical Research Methods

Nanopore native RNA sequencing of a human poly(A) transcriptome

Rachael E. Workman et al.

NATURE METHODS (2019)

Article Biochemistry & Molecular Biology

Inosine induces context-dependent recoding and translational stalling

Konstantin Licht et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemical Research Methods

Highly parallel direct RNA sequencing on an array of nanopores

Daniel R. Garalde et al.

NATURE METHODS (2018)

Review Biochemistry & Molecular Biology

Surveillance-ready transcription: nuclear RNA decay as a default fate

Stefan Bresson et al.

OPEN BIOLOGY (2018)

Article Multidisciplinary Sciences

Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions

Thomas Philipp Hoernes et al.

NATURE COMMUNICATIONS (2018)

Review Biotechnology & Applied Microbiology

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs

Carl R. Walkley et al.

GENOME BIOLOGY (2017)

Review Biochemistry & Molecular Biology

When mRNA translation meets decay

Alicia A. Bicknell et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2017)

Review Cell Biology

A-to-I editing of coding and non-coding RNAs by ADARs

Kazuko Nishikura

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Review Cell Biology

Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications

Konstantin Licht et al.

JOURNAL OF CELL BIOLOGY (2016)

Review Cell Biology

A disease spectrum for ITPA variation: advances in biochemical and clinical research

Nicholas E. Burgis

JOURNAL OF BIOMEDICAL SCIENCE (2016)

Article Clinical Neurology

Recessive ITPA Mutations Cause an Early Infantile Encephalopathy

Sietske H. Kevelam et al.

ANNALS OF NEUROLOGY (2015)

Review Biotechnology & Applied Microbiology

ITPA (inosine triphosphate pyrophosphatase): From surveillance of nucleotide pools to human disease and pharmacogenetics

Peter D. Simone et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2013)

Article Biochemical Research Methods

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran et al.

NATURE PROTOCOLS (2013)

Article Multidisciplinary Sciences

A Guanosine-Centric Mechanism for RNA Chaperone Function

Jacob K. Grohman et al.

SCIENCE (2013)

Article Biochemical Research Methods

Accurate identification of human Alu and non-Alu RNA editing sites

Gokul Ramaswami et al.

NATURE METHODS (2012)

Article Biochemistry & Molecular Biology

ITPase-deficient mice show growth retardation and die before weaning

M. Behmanesh et al.

CELL DEATH AND DIFFERENTIATION (2009)

Article Genetics & Heredity

DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency

HN Cao et al.

JOURNAL OF HUMAN GENETICS (2002)