Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 101, Issue 1, Pages 183-192Publisher
WILEY
DOI: 10.1189/jlb.2VMR1215-582R
Keywords
B cells; macrophages; infection; inflammation; autoimmunity
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Funding
- National Health and Medical Research Council of Australia [APP1049087]
- International Balzan Foundation
- Australian Postgraduate Award
- University of Queensland Diamantina Institute
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Radioprotective 105 kDa (CD180) is an unusual TLR that lacks an intracellular Toll-IL-1R signaling domain and exhibits unconventional homodimerization behavior. Differential expression and functions of radioprotective 105 kDa have been associated with immune-mediated pathologies, including infection, chronic inflammation, and autoimmune disorders. Radioprotective 105 kDa activates macrophages and B cells independently of canonical TLR signaling. Current understanding of the functional consequences of radioprotective 105 kDa signaling in B cells, macrophages, and dendritic cells indicates overlapping, but also some apparent opposing, cell-specific roles for radioprotective 105 kDa in shaping cellular functions. This review compares interactions of radioprotective 105 kDa with its coreceptors, CD19, TLR4, and TLR2; integrates recent, novel findings on radioprotective 105 kDa-mediated molecular signaling mechanisms; and summarizes current understanding of its contributions to infectious, inflammatory, and autoimmune disease.
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