4.7 Article

Post-viral fatigue in COVID-19: A review of symptom assessment methods, mental, cognitive, and physical impairment

Journal

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 142, Issue -, Pages -

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104902

Keywords

Chronic fatigue syndrome; Coronavirus; Fatigue; Neurologic manifestations; Neuropsychological tests; Physical performance

Funding

  1. Fundacao de Amparo a Pesquisa e Inovacao do Estado de Santa Catarina (FAPESC, Brazil)
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
  3. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)

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This article summarizes various aspects of assessing COVID-19 infection and proposes tools and methods for assessing long-term COVID-19 fatigue.
Coronavirus 2 is responsible for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), and the main sequela is persistent fatigue. Post-viral fatigue is common and affects patients with mild, asymptomatic coro-navirus disease-2019 (COVID-19). However, the exact mechanisms involved in developing post-COVID-19 fa-tigue remain unclear. Furthermore, physical and cognitive impairments in these individuals have been widely described. Therefore, this review aims to summarize and propose tools from a multifaceted perspective to assess COVID-19 infection. Herein, we point out the instruments that can be used to assess fatigue in long-term COVID-19: fatigue in a subjective manner or fatigability in an objective manner. For physical and mental fatigue, structured questionnaires were used to assess perceived symptoms, and physical and cognitive performance assessment tests were used to measure fatigability using reduced performance.

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