☆ 4.7 Review

Pharmacological, neural, and psychological mechanisms underlying psychedelics: A critical review

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2022)

Related references

Note: Only part of the references are listed.
Review Clinical Neurology

Models of psychedelic drug action: modulation of cortical-subcortical circuits

Manoj K. Doss et al.

Summary: Classic psychedelic drugs have potential in treating psychiatric disorders, and the involvement of the serotonin 2A receptor and the cerebral cortex is crucial in their action. Different models, including the CSTC model, REBUS model, and CCC model, have been proposed to explain the impact of 5-HT2A activation on neural systems during psychedelic drug effects.

BRAIN (2022)

Add to Collection
Review Clinical Neurology

Psychedelics and health behaviour change

Pedro J. Teixeira et al.

Summary: Healthy behaviors have a significant impact on reducing the risk of serious diseases, leading to increased interest in interventions promoting such behaviors. The potential role of psychedelic substances like psilocybin in facilitating positive lifestyle changes is being explored, along with their mechanisms of action and research findings in health behavior change science.

JOURNAL OF PSYCHOPHARMACOLOGY (2022)

Add to Collection
Review Biochemistry & Molecular Biology

A neurobiological perspective on social influence: Serotonin and social adaptation

Patricia Duerler et al.

Summary: This article reviews the neurobiological and neuropharmacological foundations of social adaptation with a focus on the role of the serotonin system. The critical role of serotonin in social learning and its potential as a target for treating social functioning impairments are highlighted. This framework has important implications for psychedelic-assisted therapy and the development of novel treatment approaches.

JOURNAL OF NEUROCHEMISTRY (2022)

Add to Collection
Article Neurosciences

Repeated lysergic acid diethylamide (LSD) reverses stress-induced anxiety-like behavior, cortical synaptogenesis deficits and serotonergic neurotransmission decline

Danilo De Gregorio et al.

Summary: Repeated LSD administration can prevent the exacerbation of anxiety-like behavior following chronic stress exposure. This effect may be mediated through increased cortical spine density and enhanced release of 5-HT neurotransmitters.

NEUROPSYCHOPHARMACOLOGY (2022)

Add to Collection
Article Neurosciences

Direct comparison of the acute effects of lysergic acid diethylamide and psilocybin in a double-blind placebo-controlled study in healthy subjects

Friederike Holze et al.

Summary: This study compared the subjective and autonomic effects of LSD and psilocybin, finding that the higher doses of both substances produced similar subjective effects, but psilocybin had weaker effects at a lower dose. Additionally, LSD and psilocybin showed differences in their effects on heart rate and blood pressure.

NEUROPSYCHOPHARMACOLOGY (2022)

Add to Collection
Review Neurosciences

Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials

Jacob S. Aday et al.

Summary: Psychedelic research is gaining significant interest, but faces challenges such as expectancy effects and effective condition masking, which may limit interpretability of results. Recommendations for improving research rigor include enhancing masking procedures and reducing participant expectancies.

PSYCHOPHARMACOLOGY (2022)

Add to Collection
Editorial Material Psychiatry

Psychopharmacology and Explanatory Pluralism

Awais Aftab et al.

JAMA PSYCHIATRY (2022)

Add to Collection
Article

Future directions for clinical psilocybin research: The relaxed symptom network.

Evan Lewis-Healey et al.

Psychology and Neuroscience (2022)

Add to Collection
Article Neurosciences

Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects

Friederike Holze et al.

Summary: This study evaluated the subjective and autonomic effects of different doses of LSD in healthy subjects. It found that LSD displayed dose-proportional pharmacokinetics and dose-dependently induced subjective responses, with a ceiling effect observed for good drug effects at 100 μg. The results suggest that future LSD research may benefit from dose finding based on these findings, and that the full psychedelic effects of LSD are primarily mediated by serotonin 5-HT2A receptor activation.

NEUROPSYCHOPHARMACOLOGY (2021)

Add to Collection
Review Psychiatry

Therapeutic effects of classic serotonergic psychedelics: A systematic review of modern-era clinical studies

Kristoffer A. A. Andersen et al.

Summary: The systematic review of modern-era clinical studies on serotonergic psychedelics drugs for mental health conditions shows promising treatment efficacy and long-lasting effects in some patients. The safety and feasibility of the studies provide important evidence for the potential of psychedelic therapy as a new treatment avenue for psychiatric conditions.

ACTA PSYCHIATRICA SCANDINAVICA (2021)

Add to Collection
Article Neurosciences

Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons

Elisa Galliano et al.

Summary: Temporary sensory deprivation can induce structural and functional plasticity in dopaminergic neurons in the olfactory bulb, resulting in changes in axon initial segment length and intrinsic excitability. This experience-dependent plasticity may help fine-tune sensory processing in the face of continuously fluctuating inputs.

JOURNAL OF NEUROSCIENCE (2021)

Add to Collection
Article Multidisciplinary Sciences

A non-hallucinogenic psychedelic analogue with therapeutic potential

Lindsay P. Cameron et al.

Summary: The study identifies key structural elements of the potential therapeutic pharmacophore of ibogaine and designs tabernanthalog, a safer, non-hallucinogenic analogue of ibogaine. Tabernanthalog is found to promote neural plasticity, reduce addiction-related behavior, and produce antidepressant effects in rodents. Through careful chemical design, it is possible to modify psychedelic compounds to produce safer, non-hallucinogenic variants with therapeutic potential.

NATURE (2021)

Add to Collection
Article Neurosciences

MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens

Felix Mueller et al.

Summary: The study found that both serotonergic hallucinogens and non-hallucinogenic substances like MDMA can induce decreased within-network connectivity, suggesting that these alterations may not be specific to hallucinogens.

NEUROPSYCHOPHARMACOLOGY (2021)

Add to Collection
Review Pharmacology & Pharmacy

The History of Psychedelics in Psychiatry

David E. Nichols et al.

Summary: Interest in the value of psychedelic drugs in psychiatry began in the early 20th century, with a focus on their potential effects on mental disorders. Over time, attention shifted to the role of psychedelics as adjuncts to psychotherapy, which has since become the main focus of research in this field.

PHARMACOPSYCHIATRY (2021)

Add to Collection
Article Multidisciplinary Sciences

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

Danilo De Gregorio et al.

Summary: Clinical studies have shown that LSD can enhance empathy and social behavior in humans. This study in male mice found that LSD promotes social behavior by potentiating glutamatergic neurotransmission in the medial prefrontal cortex through the 5-HT2A/AMPA receptors and mTOR signaling. The results suggest that activating these pathways with psychedelic drugs could be explored for treating mental disorders characterized by social behavior impairments.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection
Editorial Material Psychiatry

Psychedelics in Psychiatry-Keeping the Renaissance From Going Off the Rails

David B. Yaden et al.

Summary: The psychedelic research renaissance should focus on integrating these medications into standard care in order to progress towards effective treatment options.

JAMA PSYCHIATRY (2021)

Add to Collection
Review Neurosciences

Cognitive and behavioural flexibility: neural mechanisms and clinical considerations

Lucina Q. Uddin

Summary: Cognitive and behavioral flexibility, critical for adapting thoughts and actions under changing circumstances, can be enhanced through cognitive training, physical activity, and bilingual experience. Brain mechanisms and functional brain networks play important roles in supporting flexibility, while it can also be compromised in various diseases.

NATURE REVIEWS NEUROSCIENCE (2021)

Add to Collection
Article Biology

Self-blinding citizen science to explore psychedelic microdosing

Balazs Szigeti et al.

Summary: The study found that while there were some small but significant differences in emotional state, drug intensity, mood, energy, and creativity between microdosing and placebo groups, these results may be due to participants breaking the blind. Therefore, the study results suggest that the anecdotal benefits of microdosing may be explained by the placebo effect.

ELIFE (2021)

Add to Collection
Article Multidisciplinary Sciences

Psychedelics alter metaphysical beliefs

Christopher Timmermann et al.

Summary: After using psychedelic drugs, individuals experience lasting changes in their metaphysical beliefs, shifting away from physicalist views towards panpsychism and fatalism. These belief shifts may last for at least 6 months and are positively correlated with previous psychedelic use and improved mental health outcomes.

SCIENTIFIC REPORTS (2021)

Add to Collection
Article Psychiatry

Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

Manoj K. Doss et al.

Summary: The study investigated the enduring effects of psilocybin therapy on cognitive and neural flexibility, finding that cognitive flexibility improved post-treatment and some neural dynamics changes were associated with changes in cognitive flexibility one week after treatment.

TRANSLATIONAL PSYCHIATRY (2021)

Add to Collection
Article Medicine, General & Internal

Trial of Psilocybin versus Escitalopram for Depression

Robin Carhart-Harris et al.

Summary: The study compared the efficacy of psilocybin and escitalopram in treating patients with major depressive disorder. While there was no significant difference in antidepressant effects between the two drugs at week 6, secondary outcomes generally favored psilocybin over escitalopram, though these results were not adjusted for multiple comparisons. Larger and longer trials are needed to further compare psilocybin with established antidepressants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection
Article Multidisciplinary Sciences

Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

Natalie Hesselgrave et al.

Summary: Psilocybin has shown promising rapid and persistent antidepressant effects in mice, possibly through enhancing excitatory synapses in the hippocampus, independent of 5-HT2A receptor activation. Further research is needed to explore the potential combination of psychedelic compounds and 5-HT2AR antagonists for clinical utility in human depression.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection
Article Psychiatry

Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder A Randomized Clinical Trial

Alan K. Davis et al.

Summary: The study showed that psilocybin therapy with psychological support is effective in treating MDD, building on previous findings in patients with cancer and depression, as well as in a nonrandomized study in patients with treatment-resistant depression.

JAMA PSYCHIATRY (2021)

Add to Collection
Article Pharmacology & Pharmacy

Psychedelic Communitas: Intersubjective Experience During Psychedelic Group Sessions Predicts Enduring Changes in Psychological Wellbeing and Social Connectedness

H. Kettner et al.

Summary: This study introduces and psychometrically validates an adapted Communitas Scale to investigate psychosocial mechanisms pertinent to psychedelic ceremonies and retreats. Results show a positive relationship between participants and facilitators, and the perceived impact of emotional support, facilitating the emergence of communitas. Communitas during ceremony was significantly correlated with increases in psychological wellbeing and social connectedness.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection
Article Pharmacology & Pharmacy

Set and Setting in the Santo Daime

Ido Hartogsohn

Summary: This paper explores the formation of psychedelic effects in the context of the Santo Daime religion, emphasizing the profound impact of set and setting on psychedelic effects. The detailed description of the initiation mechanism in the Santo Daime tradition provides a template for future research.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection
Article Neurosciences

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Ling-Xiao Shao et al.

Summary: The study showed that psilocybin can induce rapid and lasting synaptic rewiring in the cortex, increasing spine size and density. This structural change may have potential implications for long-term integration of experiences and lasting beneficial actions.

NEURON (2021)

Add to Collection
Article Behavioral Sciences

From many to (n)one: Meditation and the plasticity of the predictive mind

Ruben E. Laukkonen et al.

Summary: This paper explores how meditation can affect predictive processing in the brain, suggesting that deconstructive meditation can gradually reduce cognitive processes and lead to a state of pure awareness. Meditation helps diminish habitual prediction formation, including predictions of the self.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

Add to Collection
Review Pharmacology & Pharmacy

Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics

Lily R. Aleksandrova et al.

Summary: The emerging therapeutic efficacy of ketamine and classical psychedelics for depression has sparked considerable interest in the mechanisms underlying neuroplasticity. Preclinical and clinical evidence suggests that these drugs induce synaptic, structural, and functional changes, particularly in pyramidal neurons in the prefrontal cortex, resulting in adaptive rewiring of pathological neurocircuitry.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

Add to Collection
Article Pharmacology & Pharmacy

Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin

Friederike Holze et al.

Summary: The study found that LSD can enhance empathy with dose-dependent effects on emotional empathy and also increase plasma oxytocin levels, partially independent of the primary action on 5-HT2A receptors. These findings provide important implications for further research investigating the therapeutic effects of LSD in patients with empathy deficits and impairments in social functioning.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection
Article Chemistry, Medicinal

Working with Weirdness: A Response to Moving Past Mysticism in Psychedelic Science

Joost J. Breeksema et al.

Summary: Acknowledging the variety and unique characteristics of psychedelic experiences is essential for research in this area, as it helps in understanding the therapeutic effects of psychedelics and emphasizes the need for more diverse experiences and participants in studies.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Add to Collection
Article Chemistry, Medicinal

Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

Nadia R. P. W. Hutten et al.

Summary: The study found that single low doses of LSD can significantly increase BDNF levels in healthy volunteers in a short period of time, providing a new direction for researching the use of LSD in patient populations.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Add to Collection
Article Chemistry, Medicinal

Consciousness, Religion, and Gurus: Pitfalls of Psychedelic Medicine

Matthew W. Johnson

Summary: The passage identifies pitfalls in the study of psychedelic compounds, such as the lack of precision in defining consciousness, the inappropriate introduction of religious/spiritual beliefs by investigators or clinicians, and the clinical boundaries and ethical challenges associated with psychedelic treatments.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Add to Collection
Article Chemistry, Medicinal

Combining Psychedelic and Mindfulness Interventions: Synergies to Inform Clinical Practice

Jake E. Payne et al.

Summary: Psychedelic and mindfulness interventions have shown to improve mental health and wellbeing, but they also have specific challenges. The authors propose combining these two interventions for greater benefit, with psychedelic treatments initiating and motivating while mindfulness interventions integrating and maintaining the effects. Testable hypotheses and future research are outlined regarding the synergistic action of these interventions for improved clinical outcomes.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Add to Collection
Article Psychiatry

Bio-psycho-social interaction: an enactive perspective

Sanneke de Haan

Summary: Physiological, psychological, and social processes all play important roles in the development of psychiatric disorders, with the reductionist model focusing only on physiological processes and the biopsychosocial model emphasizing the unique contributions of psychological and social processes. However, the biopsychosocial model lacks an explanation of how these processes causally interact, which is addressed by the enactive approach that views cognition as embodied and embedded, and considers the interconnectedness between body, mind, and world in understanding the development of psychiatric disorders.

INTERNATIONAL REVIEW OF PSYCHIATRY (2021)

Add to Collection
Article Psychology, Clinical

LSD acutely impairs working memory, executive functions, and cognitive flexibility, but not risk-based decision-making

Thomas Pokorny et al.

PSYCHOLOGICAL MEDICINE (2020)

Add to Collection
Article Neurosciences

Distinct acute effects of LSD, MDMA, and d-amphetamine in healthy subjects

Friederike Holze et al.

NEUROPSYCHOPHARMACOLOGY (2020)

Add to Collection
Article Multidisciplinary Sciences

Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings

Matthias Forstmann et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection
Article Neurosciences

Tripping on nothing: placebo psychedelics and contextual factors

Jay A. Olson et al.

PSYCHOPHARMACOLOGY (2020)

Add to Collection
Article Neurosciences

Broadening Your Mind to Include Others: The relationship between serotonergic psychedelic experiences and maladaptive narcissism

Valerie van Mulukom et al.

PSYCHOPHARMACOLOGY (2020)

Add to Collection
Article Clinical Neurology

Survey of entity encounter experiences occasioned by inhaled N,N-dimethyltryptamine: Phenomenology, interpretation, and enduring effects

Alan K. Davis et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2020)

Add to Collection
Article Neurosciences

The claustrum coordinates cortical slow-wave activity

Kimiya Narikiyo et al.

NATURE NEUROSCIENCE (2020)

Add to Collection
Article Neurosciences

Psilocybin acutely alters the functional connectivity of the claustrum with brain networks that support perception, memory, and attention

Frederick S. Barrett et al.

NEUROIMAGE (2020)

Add to Collection
Article Neurosciences

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

N. L. Mason et al.

NEUROPSYCHOPHARMACOLOGY (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

Kuglae Kim et al.

CELL (2020)

Add to Collection
Review Neurosciences

Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders

Franz X. Vollenweider et al.

NATURE REVIEWS NEUROSCIENCE (2020)

Add to Collection
Review Behavioral Sciences

Potential safety, benefits, and influence of the placebo effect in microdosing psychedelic drugs: A systematic review

Genis Ona et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

Add to Collection
Article Psychology, Multidisciplinary

Mystical and Other Alterations in Sense of Self: An Expanded Framework for Studying Nonordinary Experiences

Ann Taves

PERSPECTIVES ON PSYCHOLOGICAL SCIENCE (2020)

Add to Collection
Article Psychology, Clinical

Psychedelic Microdosing: Prevalence and Subjective Effects

Lindsay P. Cameron et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2020)

Add to Collection
Review Psychology, Clinical

The use of the psychological flexibility model to support psychedelic assisted therapy

Rosalind Watts et al.

JOURNAL OF CONTEXTUAL BEHAVIORAL SCIENCE (2020)

Add to Collection
Article Psychology, Clinical

Psychological flexibility mediates the relations between acute psychedelic effects and subjective decreases in depression and anxiety

Alan K. Davis et al.

JOURNAL OF CONTEXTUAL BEHAVIORAL SCIENCE (2020)

Add to Collection
Article Neurosciences

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

Martin K. Madsen et al.

NEUROPSYCHOPHARMACOLOGY (2019)

Add to Collection
Article Multidisciplinary Sciences

Effective connectivity changes in LSD-induced altered states of consciousness in humans

Katrin H. Preller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Add to Collection
Article Multidisciplinary Sciences

Oxytocin-dependent reopening of a social reward learning critical period with MDMA

Romain Nardou et al.

NATURE (2019)

Add to Collection
Article Clinical Neurology

Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory

Leor Roseman et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2019)

Add to Collection
Editorial Material Clinical Neurology

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research

Kim P. C. Kuypers et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2019)

Add to Collection
Review Pharmacology & Pharmacy

REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

R. L. Carhart-Harris et al.

PHARMACOLOGICAL REVIEWS (2019)

Add to Collection
Article Neurosciences

Resting state functional connectivity and cognitive task-related activation of the human claustrum

Samuel R. Krimmel et al.

NEUROIMAGE (2019)

Add to Collection
Article Neurosciences

Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects

Lukasz Smigielski et al.

NEUROIMAGE (2019)

Add to Collection
Article Multidisciplinary Sciences

Characterization and prediction of acute and sustained response to psychedelic psilocybin in a mindfulness group retreat

Lukasz Smigielski et al.

SCIENTIFIC REPORTS (2019)

Add to Collection
Review Pharmacology & Pharmacy

Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function

Matthew W. Johnson et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Add to Collection
Review Psychology, Multidisciplinary

nStudying the experience of meditation through Micro-phenomenology

Claire Petitmengin et al.

CURRENT OPINION IN PSYCHOLOGY (2019)

Add to Collection
Article Psychology, Multidisciplinary

Modulation of Serum Brain-Derived Neurotrophic Factor by a Single Dose of Ayahuasca: Observation From a Randomized Controlled Trial

Raissa Nobrega de Almeida et al.

FRONTIERS IN PSYCHOLOGY (2019)

Add to Collection
Article Psychology, Clinical

Sub-Acute Effects of Psilocybin on Empathy, Creative Thinking, and Subjective Well-Being

Natasha L. Mason et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2019)

Add to Collection
Article Psychology, Multidisciplinary

The development of the Awe Experience Scale (AWE-S): A multifactorial measure for a complex emotion

David B. Yaden et al.

JOURNAL OF POSITIVE PSYCHOLOGY (2019)

Add to Collection
Article Psychology, Biological

Psychedelics as a treatment for disorders of consciousness

Gregory Scott et al.

NEUROSCIENCE OF CONSCIOUSNESS (2019)

Add to Collection
Article Religion

The role of alcohol in expectancy-driven mystical experiences: a pre-registered field study using placebo brain stimulation

David L. R. Maij et al.

RELIGION BRAIN & BEHAVIOR (2019)

Add to Collection
Article Social Sciences, Interdisciplinary

Causation in Mixed Methods Research: The Meeting of Philosophy, Science, and Practice

R. Burke Johnson et al.

JOURNAL OF MIXED METHODS RESEARCH (2019)

Add to Collection
Review Psychology, Experimental

Absorption and spiritual experience: A review of evidence and potential mechanisms

Michael Lifshitz et al.

CONSCIOUSNESS AND COGNITION (2019)

Add to Collection
Article Clinical Neurology

Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors

Roland R. Griffiths et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2018)

Add to Collection
Review Neurosciences

Psychiatry & the psychedelic drugs. Past, present & future

James J. H. Rucker et al.

NEUROPHARMACOLOGY (2018)

Add to Collection
Article Neurosciences

MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections

Manoj K. Doss et al.

NEUROPSYCHOPHARMACOLOGY (2018)

Add to Collection
Article Psychology, Clinical

Acute LSD effects on response inhibition neural networks

A. Schmidt et al.

PSYCHOLOGICAL MEDICINE (2018)

Add to Collection
Article Neurosciences

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences

Theresa M. Carbonaro et al.

PSYCHOPHARMACOLOGY (2018)

Add to Collection
Editorial Material Neurosciences

The 21st century psychedelic renaissance: heroic steps forward on the back of an elephant

Ben Sessa

PSYCHOPHARMACOLOGY (2018)

Add to Collection
Editorial Material Neurosciences

Psychedelics and connectedness

R. L. Carhart-Harris et al.

PSYCHOPHARMACOLOGY (2018)

Add to Collection
Review Neurosciences

The Predictive Coding Account of Psychosis

Philipp Sterzer et al.

BIOLOGICAL PSYCHIATRY (2018)

Add to Collection
Article Clinical Neurology

Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression

Taylor Lyons et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2018)

Add to Collection
Review Neurosciences

The entropic brain - revisited

Robin L. Carhart-Harris

NEUROPHARMACOLOGY (2018)

Add to Collection
Review Behavioral Sciences

Serotonergic psychedelics and personality: A systematic review of contemporary research

Jose Carlos Bouso et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

Add to Collection
Article Cell Biology

Psychedelics Promote Structural and Functional Neural Plasticity

Calvin Ly et al.

CELL REPORTS (2018)

Add to Collection
Review Pharmacology & Pharmacy

Neuroendocrine Associations Underlying the Persistent Therapeutic Effects of Classic Serotonergic Psychedelics

Emmanuelle A. D. Schindler et al.

FRONTIERS IN PHARMACOLOGY (2018)

Add to Collection
Article Anatomy & Morphology

Claustrum circuit components for top-down input processing and cortical broadcast

Michael G. White et al.

BRAIN STRUCTURE & FUNCTION (2018)

Add to Collection
Article Biochemistry & Molecular Biology

The Claustrum Supports Resilience to Distraction

Gal Atlan et al.

CURRENT BIOLOGY (2018)

Add to Collection
Article Neurosciences

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: effects on cognition

Frederick S. Barrett et al.

PSYCHOPHARMACOLOGY (2018)

Add to Collection
Article Neurosciences

Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting

Luisa Prochazkova et al.

PSYCHOPHARMACOLOGY (2018)

Add to Collection
Article Biology

Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

Katrin H. Preller et al.

ELIFE (2018)

Add to Collection
Article Psychology, Clinical

The Nondual Awareness Dimensional Assessment (NADA): New Tools to Assess Nondual Traits and States of Consciousness Occurring Within and Beyond the Context of Meditation

Adam W. Hanley et al.

PSYCHOLOGICAL ASSESSMENT (2018)

Add to Collection
Review Psychiatry

Awe: a putative mechanism underlying the effects of classic psychedelic-assisted psychotherapy

Peter S. Hendricks

INTERNATIONAL REVIEW OF PSYCHIATRY (2018)

Add to Collection
Article Pharmacology & Pharmacy

Psychedelics as Medicines: An Emerging New Paradigm

D. E. Nichols et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2017)

Add to Collection
Article Neurosciences

Cortical Hierarchy Governs Rat Claustrocortical Circuit Organization

Michael G. White et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2017)

Add to Collection
Article Psychology, Clinical

Long-term follow-up of psilocybin-facilitated smoking cessation

Matthew W. Johnson et al.

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2017)

Add to Collection
Article Clinical Neurology

Effect of Psilocybin on Empathy and Moral Decision-Making

Thomas Pokorny et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2017)

Add to Collection
Article Clinical Neurology

Lifetime experience with (classic) psychedelics predicts pro-environmental behavior through an increase in nature relatedness

Matthias Forstmann et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2017)

Add to Collection
Review Behavioral Sciences

The social transmission of metacontrol policies: Mechanisms underlying the interpersonal transfer of persistence and flexibility

Bernhard Hommel et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Add to Collection
Review Pharmacology & Pharmacy

Psychedelic Drugs in Biomedicine

Evan J. Kyzar et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Add to Collection
Article Multidisciplinary Sciences

Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin

Michael M. Schartner et al.

SCIENTIFIC REPORTS (2017)

Add to Collection
Article Immunology

Self unbound: ego dissolution in psychedelic experience

Chris Letheby et al.

OPEN FORUM INFECTIOUS DISEASES (2017)

Add to Collection
Review Psychology, Clinical

Toward a Functional View of the p Factor in Psychopathology

Charles S. Carver et al.

CLINICAL PSYCHOLOGICAL SCIENCE (2017)

Add to Collection
Article Psychology, Social

Neuroticism is associated with challenging experiences with psilocybin mushrooms

Frederick S. Barrett et al.

PERSONALITY AND INDIVIDUAL DIFFERENCES (2017)

Add to Collection
Article Psychology, Social

The Dark Side of the Sublime: Distinguishing a Threat-Based Variant of Awe

Amie M. Gordon et al.

JOURNAL OF PERSONALITY AND SOCIAL PSYCHOLOGY (2017)

Add to Collection
Article Psychology, Multidisciplinary

Of Roots and Fruits: A Comparison of Psychedelic and Nonpsychedelic Mystical Experiences

David B. Yaden et al.

JOURNAL OF HUMANISTIC PSYCHOLOGY (2017)

Add to Collection
Article Psychology, Multidisciplinary

The Varieties of Self-Transcendent Experience

David Bryce Yaden et al.

REVIEW OF GENERAL PSYCHOLOGY (2017)

Add to Collection
Article Biochemistry & Molecular Biology

The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

Katrin H. Preller et al.

CURRENT BIOLOGY (2017)

Add to Collection
Article Neurosciences

Exploring the therapeutic potential of Ayahuasca: acute intake increases mindfulness-related capacities

Joaquim Soler et al.

PSYCHOPHARMACOLOGY (2016)

Add to Collection
Editorial Material Psychology, Biological

Attention alters predictive processing

Andy Clark

BEHAVIORAL AND BRAIN SCIENCES (2016)

Add to Collection
Review Neurosciences

Oxytocin Conditions Intergroup Relations Through Upregulated In-Group Empathy, Cooperation, Conformity, and Defense

Carsten K. W. De Dreu et al.

BIOLOGICAL PSYCHIATRY (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution

Enzo Tagliazucchi et al.

CURRENT BIOLOGY (2016)

Add to Collection
Article Clinical Neurology

Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience

Thomas Pokorny et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2016)

Add to Collection
Article Neurosciences

Ego-Dissolution and Psychedelics: Validation of the Ego-Dissolution Inventory (EDI)

Matthew M. Nour et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2016)

Add to Collection
Article Neurosciences

LSD-Induced Entropic Brain Activity Predicts Subsequent Personality Change

A. V. Lebedev et al.

HUMAN BRAIN MAPPING (2016)

Add to Collection
Article Clinical Neurology

Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences

Theresa M. Carbonaro et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2016)

Add to Collection
Article Clinical Neurology

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial

Roland R. Griffiths et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2016)

Add to Collection
Article Clinical Neurology

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

Stephen Ross et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2016)

Add to Collection
Review Clinical Neurology

Set and setting, psychedelics and the placebo response: An extra-pharmacological perspective on psychopharmacology

Ido Hartogsohn

JOURNAL OF PSYCHOPHARMACOLOGY (2016)

Add to Collection
Article Neurosciences

Thalamus plays a central role in ongoing cortical functioning

S. Murray Sherman

NATURE NEUROSCIENCE (2016)

Add to Collection
Article Behavioral Sciences

A placebo-controlled investigation of synaesthesia-like experiences under LSD

Devin B. Terhune et al.

NEUROPSYCHOLOGIA (2016)

Add to Collection
Article Neurosciences

LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality

Patrick C. Dolder et al.

NEUROPSYCHOPHARMACOLOGY (2016)

Add to Collection
Article Pharmacology & Pharmacy

The hallucinogen D-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors

Danilo De Gregorio et al.

PHARMACOLOGICAL RESEARCH (2016)

Add to Collection
Article Multidisciplinary Sciences

Neural correlates of the LSD experience revealed by multimodal neuroimaging

Robin L. Carhart-Harris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection
Article Neurosciences

Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking

K. P. C. Kuypers et al.

PSYCHOPHARMACOLOGY (2016)

Add to Collection
Review Pharmacology & Pharmacy

Psychedelics

David E. Nichols

PHARMACOLOGICAL REVIEWS (2016)

Add to Collection
Article Psychology, Multidisciplinary

The Language of Ineffability: Linguistic Analysis of Mystical Experiences

David B. Yaden et al.

PSYCHOLOGY OF RELIGION AND SPIRITUALITY (2016)

Add to Collection
Article Psychiatry

Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

Robin L. Carhart-Harris et al.

LANCET PSYCHIATRY (2016)

Add to Collection
Review Neurosciences

The Brain's Default Mode Network

Marcus E. Raichle

ANNUAL REVIEW OF NEUROSCIENCE, VOL 38 (2015)

Add to Collection
Article Psychiatry

Neural substrates of cognitive flexibility in cocaine and gambling addictions

Antonio Verdejo-Garcia et al.

BRITISH JOURNAL OF PSYCHIATRY (2015)

Add to Collection
Editorial Material Behavioral Sciences

Registered Reports: Realigning incentives in scientific publishing

Christopher D. Chambers et al.

CORTEX (2015)

Add to Collection
Article Clinical Neurology

Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin

Frederick S. Barrett et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

Add to Collection
Review Clinical Neurology

Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?

Tomislav Majic et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

Add to Collection
Article Clinical Neurology

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

Michael P. Bogenschutz et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

Add to Collection
Article Psychiatry

Association of Thalamic Dysconnectivity and Conversion to Psychosis in Youth and Young Adults at Elevated Clinical Risk

Alan Anticevic et al.

JAMA PSYCHIATRY (2015)

Add to Collection
Article Neurosciences

LSD enhances suggestibility in healthy volunteers

R. L. Carhart-Harris et al.

PSYCHOPHARMACOLOGY (2015)

Add to Collection
Editorial Material Biochemistry & Molecular Biology

Empathy and compassion

Tania Singer et al.

CURRENT BIOLOGY (2014)

Add to Collection
Review Psychiatry

Pheno-phenotypes: a holistic approach to the psychopathology of schizophrenia

Giovanni Stanghellini et al.

CURRENT OPINION IN PSYCHIATRY (2014)

Add to Collection
Article Neurosciences

The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs

Robin L. Carhart-Harris et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2014)

Add to Collection
Article Neurosciences

Effects of MDMA and Intranasal Oxytocin on Social and Emotional Processing

Matthew G. Kirkpatrick et al.

NEUROPSYCHOPHARMACOLOGY (2014)

Add to Collection
Article Multidisciplinary Sciences

No Evidence that MDMA-Induced Enhancement of Emotional Empathy Is Related to Peripheral Oxytocin Levels or 5-HT1a Receptor Activation

Kim P. C. Kuypers et al.

PLOS ONE (2014)

Add to Collection
Article Endocrinology & Metabolism

Plasma oxytocin concentrations following MDMA or intranasal oxytocin in humans

Matthew G. Kirkpatrick et al.

PSYCHONEUROENDOCRINOLOGY (2014)

Add to Collection
Review Neurosciences

Ketamine administration in depressive disorders: a systematic review and meta-analysis

Guillaume Fond et al.

PSYCHOPHARMACOLOGY (2014)

Add to Collection
Review Neurosciences

The claustrum in review

Brian N. Mathur

FRONTIERS IN SYSTEMS NEUROSCIENCE (2014)

Add to Collection
Review Pharmacology & Pharmacy

Classical hallucinogens as antidepressants? A review of pharmacodynamics and putative clinical roles

David Baumeister et al.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2014)

Add to Collection
Article Psychology, Clinical

The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?

Avshalom Caspi et al.

CLINICAL PSYCHOLOGICAL SCIENCE (2014)

Add to Collection
Article Psychology, Clinical

Network Analysis: An Integrative Approach to the Structure of Psychopathology

Denny Borsboom et al.

ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9 (2013)

Add to Collection
Article Psychology, Biological

Whatever next? Predictive brains, situated agents, and the future of cognitive science

Andy Clark

BEHAVIORAL AND BRAIN SCIENCES (2013)

Add to Collection
Article Neurosciences

The Amsterdam Resting-State Questionnaire reveals multiple phenotypes of resting-state cognition

B. Alexander Diaz et al.

Frontiers in Human Neuroscience (2013)

Add to Collection
Article Neurosciences

Broadband Cortical Desynchronization Underlies the Human Psychedelic State

Suresh D. Muthukumaraswamy et al.

JOURNAL OF NEUROSCIENCE (2013)

Add to Collection
Article Neurosciences

Acute effects of ayahuasca on neuropsychological performance: differences in executive function between experienced and occasional users

Jose Carlos Bouso et al.

PSYCHOPHARMACOLOGY (2013)

Add to Collection
Review Behavioral Sciences

Oxytocin modulates cooperation within and competition between groups: An integrative review and research agenda

Carsten K. W. De Dreu

HORMONES AND BEHAVIOR (2012)

Add to Collection
Article Clinical Neurology

Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials

Teri S. Krebs et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2012)

Add to Collection
Article Neurosciences

Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers

Boris B. Quednow et al.

NEUROPSYCHOPHARMACOLOGY (2012)

Add to Collection
Article Multidisciplinary Sciences

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

Robin L. Carhart-Harris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection
Review Neurosciences

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

Adam L. Halberstadt et al.

NEUROPHARMACOLOGY (2011)

Add to Collection
Article Neurosciences

Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effects

Roland R. Griffiths et al.

PSYCHOPHARMACOLOGY (2011)

Add to Collection
Editorial Material Biochemistry & Molecular Biology

Visual Trails: Do the Doors of Perception Open Periodically?

Julien Dubois et al.

PLOS BIOLOGY (2011)

Add to Collection
Article Neurosciences

OPINION The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

Franz X. Vollenweider et al.

NATURE REVIEWS NEUROSCIENCE (2010)

Add to Collection
Article Multidisciplinary Sciences

Psychometric Evaluation of the Altered States of Consciousness Rating Scale (OAV)

Erich Studerus et al.

PLOS ONE (2010)

Add to Collection
Article Biology

Predictive coding under the free-energy principle

Karl J. Friston et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2009)

Add to Collection
Article Neurosciences

Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis

Joerg Daumann et al.

PSYCHOPHARMACOLOGY (2008)

Add to Collection
Review Pharmacology & Pharmacy

Serotonin research: contributions to understanding psychoses

Mark A. Geyer et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2008)

Add to Collection
Article Behavioral Sciences

Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action

Danuta Marona-Lewicka et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2007)

Add to Collection
Article Neurosciences

The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval

Franz X. Vollenweider et al.

NEUROPSYCHOPHARMACOLOGY (2007)

Add to Collection
Article Neurosciences

A role for oxytocin and 5-HT1A receptors in the prosocial effects of 3,4-methylenedioxymethamphetamine (ecstasy)

M. R. Thompson et al.

NEUROSCIENCE (2007)

Add to Collection
Article Clinical Neurology

Effects of psilocybin on time perception and temporal control of behaviour in humans

Marc Wittmann et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2007)

Add to Collection
Article Psychology, Clinical

Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder

Francisco A. Moreno et al.

JOURNAL OF CLINICAL PSYCHIATRY (2006)

Add to Collection
Article Neurosciences

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance

R. R. Griffiths et al.

PSYCHOPHARMACOLOGY (2006)

Add to Collection
Article Neurosciences

Inhibition of return in the human 5HT2A agonist and NMDA antagonist model of psychosis

E Gouzoulis-Mayfrank et al.

NEUROPSYCHOPHARMACOLOGY (2006)

Add to Collection
Article Neurosciences

Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors

OL Carter et al.

JOURNAL OF COGNITIVE NEUROSCIENCE (2005)

Add to Collection
Article Psychology, Clinical

The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms for repeat administration

MM Kurtz et al.

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2004)

Add to Collection
Review Pharmacology & Pharmacy

Hallucinogens

DE Nichols

PHARMACOLOGY & THERAPEUTICS (2004)

Add to Collection
Article Psychology, Experimental

Approaching awe, a moral, spiritual, and aesthetic emotion

D Keltner et al.

COGNITION & EMOTION (2003)

Add to Collection
Review Clinical Neurology

The psychoneuroimmuno-pathophysiology of cytokine-induced depression in humans

M Wichers et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2002)

Add to Collection
Article Neurosciences

A single dose of lysergic acid diethylamide influences gene expression patterns within the mammalian brain

CD Nichols et al.

NEUROPSYCHOPHARMACOLOGY (2002)

Add to Collection
Review Neurosciences

A systems model of altered consciousness: Integrating natural and drug-induced psychoses

FX Vollenweider et al.

BRAIN RESEARCH BULLETIN (2001)

Add to Collection
Review Radiology, Nuclear Medicine & Medical Imaging

Diffusion tensor imaging: Concepts and applications

D Le Bihan et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2001)

Add to Collection
Article Psychology, Educational

The Jefferson Scale of Physician Empathy: Development and preliminary psychometric data

M Hojat et al.

EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT (2001)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.