Journal
NEURON
Volume 111, Issue 18, Pages 2916-2928Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2022.07.012
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Funding
- National Institutes of Health [EY014867, EY018599, CA168875, CA21765]
- American Lebanese Syrian Associated Charities
- Howard Hughes Medical Institute, Alexs Lemonade Stand, Tully Family, and Passano Foundation
- Alexs Lemonade Stand
- Hyundai Hope On Wheels
- National Pediatric Cancer Foundations
- Damon Runyon Cancer Research Foundation
- Sohn Conference Foundation [DRSG-33P-20]
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Neuroblastoma, a deadly cancer in children, may be caused by developmental arrest of neural-crest-derived progenitor cells. Understanding this concept could lead to new clinical management strategies.
Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differ-entiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma forma-tion. The developmental arrest of these cell types explains many biological features of the disease, including its cellular heterogeneity, mutational spectrum, spontaneous regression, and response to drugs that induce tumor cell differentiation. In this review, we provide evidence that supports the notion that arrested neural -crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease.
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