Journal
NEUROBIOLOGY OF AGING
Volume 117, Issue -, Pages 59-70Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2022.05.002
Keywords
Primary progressive aphasia; Alzheimer?s disease; Amyloid biomarkers; Brain metabolism; Neuropsychology; Disease progression
Categories
Funding
- Fondazione Cassa di Risparmio di Firenze [ECRF16 -CONTRIBUTO 2015.0713]
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This study aimed to identify features associated with different disease trajectories in AD-related PPA, finding that impaired writing and high t-tau concentration may be related to progression to total loss of speech, while impaired single-word comprehension may be associated with loss of functional autonomy. Additionally, different brain metabolic patterns were observed between progressing and non-progressing patients in terms of speech and functional autonomy loss.
We aimed to identify features associated with different disease trajectories in Alzheimer's disease (AD)related primary progressive aphasia (PPA). We considered 23 patients diagnosed with AD-related PPA. All patients underwent neuropsychological evaluation, 18 F-Fluorodeoxyglucose-PET brain scan, CSF biomarkers measurement and APOE genotype analysis at baseline and underwent neurological follow-up for a mean time of 3 years. Patients who progressed to total loss of speech (TLoS + ) had greater impairment in writing and higher t-tau concentration as compared to TLoS - patients. Patients who progressed to loss of functional autonomy (LoFA + ) had greater impairment in single-word comprehension as compared to patients who maintained autonomy in self-care. Furthermore, 18 F-FDG-PET SPM analyses revealed different brain metabolic patterns between TLoS + and TLoS - and between LoFA + and LoFA -. In conclusion, linguistic profile, CSF t-tau and brain metabolic pattern might be useful tools to predict progression to total loss of speech and loss of functional autonomy in AD-related PPA patients.(c) 2022 Elsevier Inc. All rights reserved.
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