Journal
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Volume 396, Issue 2, Pages 173-190Publisher
SPRINGER
DOI: 10.1007/s00210-022-02300-9
Keywords
G proteins; Bacterial protein toxins; C. difficile toxin TcdB; C. difficile ADP-ribosyltransferase CDT; Pseudomembranous colitis; Toxin receptors; Toxin up-take
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This narrative review presents selected findings on Clostridioides difficile toxins. It starts with a personal perspective on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in Gunter Schultz's laboratory in Heidelberg, and then highlights milestones in C. difficile toxin research, with a focus on toxin B (TcdB). The review covers various aspects of TcdB, including its structure, receptor binding, internalization, refolding, intracellular actions, and treatment of C. difficile infection.
Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Gunter Schultz in Heidelberg, milestones of C. difficile toxin research are presented with the focus on toxin B (TcdB), covering toxin structure, receptor binding, toxin up-take and refolding, the intracellular actions of TcdB, and the treatment of C. difficile infection.
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