Reassessing the relationship between mRNA levels and protein abundance in exercised skeletal muscles

A long-standing paradigm in molecular biology assumes a direct relationship between increases in mRNA levels and the abundance of the proteins they encode. Here, we challenge our understanding of the complex relationship between changes in the skeletal muscle transcriptome and proteome in response to repeated muscle contractions. Bishop and Hawley argue against a direct relationship between changes in mRNA levels and the abundance of the proteins they encode in skeletal muscles in response to exercise.

Automated summary

This article challenges the long-standing assumption in molecular biology that there is a direct relationship between mRNA levels and protein abundance. Bishop and Hawley argue against this assumption in the context of skeletal muscle responses to exercise.