Do psychedelics have therapeutic potential for obesity?

Article Psychiatry

Chronic Treatment With Psilocybin Decreases Changes in Body Weight in a Rodent Model of Obesity

Joyce Huang et al.

Summary: In this study, researchers assessed the effects of psilocybin and metformin on body weight in obese rats. The results showed that psilocybin significantly reduced weight gain and decreased high calorie food intake.

FRONTIERS IN PSYCHIATRY (2022)

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Article Psychiatry

Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

Nicole Fadahunsi et al.

Summary: The effects of psilocybin on feeding behavior and energy metabolism in mice were evaluated. It was found that psilocybin had no significant effects on food intake and body weight. A single dose of psilocybin had a substantial impact on the prefrontal cortex transcriptome but did not alter the diet-induced obese mice's feeding behavior and body weight.

TRANSLATIONAL PSYCHIATRY (2022)

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Article Psychiatry

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder A Randomized Clinical Trial

Michael P. Bogenschutz et al.

Summary: This study aimed to evaluate the effects of high-dose psilocybin on patients with AUD. The results showed that psilocybin combined with psychotherapy significantly decreased the percentage of heavy drinking days.

JAMA PSYCHIATRY (2022)

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Editorial Material Psychiatry

The Current Status of Psychedelics in Psychiatry

David Nutt et al.

JAMA PSYCHIATRY (2021)

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Article Clinical Neurology

Associations between lifetime classic psychedelic use and markers of physical health

Otto Simonsson et al.

Summary: The study suggests that individuals who have tried classic psychedelics may benefit from better physical health, including improved overall health and lower risks of being overweight or obese. Additionally, those who have tried classic psychedelics have lower odds of having heart conditions and/or cancer in the past 12 months.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

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Review Neurosciences