Journal
NATURE IMMUNOLOGY
Volume 23, Issue 9, Pages 1293-1294Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41590-022-01297-w
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Full activation of ZAP70 enables T cells to discriminate between TCR antigens of varying affinities and respond only to high-affinity antigens.
A key biochemical event that enables T cells to discriminate between TCR antigens of varying affinities and to respond only to high-affinity antigens is full activation of the kinase ZAP70.
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