Journal
NATURE IMMUNOLOGY
Volume 23, Issue 9, Pages 1297-1299Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41590-022-01296-x
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A new study reveals the differential binding manner of CTLA-4 to CD80 and CD86, which plays a crucial role in immune tolerance regulation.
The inhibitory checkpoint molecule CTLA-4 is essential for regulatory T cell function. A new study highlights the differential manner in which CTLA-4 binds CD80 and CD86, which determines its cellular fate and orchestrates immune tolerance regulation.
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