Journal
NATURE GENETICS
Volume 54, Issue 11, Pages 1736-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41588-022-01184-y
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Funding
- National Key Research and Development Program of China [2020YFE0202300]
- National Natural Science Foundation of China [U1901201, 31771879]
- Science and Technology major program of Hubei Province [2021ABA011]
- Young Elite Scientist Sponsorship Program of the China Association for Science and Technology [2019QNRC001]
- US National Science Foundation [1546719, 1822330]
- United States Department of Agriculture Hatch project [CADPLS2066H]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1822330, 1546719] Funding Source: National Science Foundation
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A study conducted on genomic variation in maize and all wild relatives of the genus Zea identified over 70 million single-nucleotide polymorphisms. The research focused on adaptive alleles in highland teosinte and temperate maize, highlighting the key role of flowering-time-related pathways in their adaptation.
Maize is a globally valuable commodity and one of the most extensively studied genetic model organisms. However, we know surprisingly little about the extent and potential utility of the genetic variation found in wild relatives of maize. Here, we characterize a high-density genomic variation map from 744 genomes encompassing maize and all wild taxa of the genus Zea, identifying over 70 million single-nucleotide polymorphisms. The variation map reveals evidence of selection within taxa displaying novel adaptations. We focus on adaptive alleles in highland teosinte and temperate maize, highlighting the key role of flowering-time-related pathways in their adaptation. To show the utility of variants in these data, we generate mutant alleles for two flowering-time candidate genes. This work provides an extensive sampling of the genetic diversity of Zea, resolving questions on evolution and identifying adaptive variants for direct use in modern breeding.
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