4.8 Editorial Material

Genomic insights into TASK-1 reveal functional roles in sleep apnea

Journal

NATURE GENETICS
Volume 54, Issue 10, Pages 1451-1452

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41588-022-01195-9

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Mutations in the KCNK3 gene found in sleep apnea patients affect the X-gate function of the TASK-1 channel, resulting in an increase in potassium current and open probability, as well as impaired sensitivity to G-protein-coupled receptor inhibitors.
KCNK3 mutations identified in sleep apnea probands affect TASK-1 X-gate function. These changes lead to an increase in potassium current and open probability, as well as impaired sensitivity to G-protein-coupled receptor inhibitors.

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