Genomic insights into TASK-1 reveal functional roles in sleep apnea

KCNK3 mutations identified in sleep apnea probands affect TASK-1 X-gate function. These changes lead to an increase in potassium current and open probability, as well as impaired sensitivity to G-protein-coupled receptor inhibitors.

Automated summary

Mutations in the KCNK3 gene found in sleep apnea patients affect the X-gate function of the TASK-1 channel, resulting in an increase in potassium current and open probability, as well as impaired sensitivity to G-protein-coupled receptor inhibitors.